Pseudopolyps are a well described entity in the literature and even though the exact pathogenesis of their formation is not completely understood, they are considered non-neoplastic lesions originating from the mucosa...Pseudopolyps are a well described entity in the literature and even though the exact pathogenesis of their formation is not completely understood, they are considered non-neoplastic lesions originating from the mucosa after repeated periods of inflammation and ulceration associated with excessive healing processes. Their occurrence is less common in Crohn's disease than in ulcerative colitis, and their overall prevalence ranges from 4% to 74%; moreover, they are found more often in colon but have been detected in other parts of the gastrointestinal tract as well. When their size exceeds the arbitrary point of 1.5 cm, they are classified as giant pseudopolyps. Clinical evaluation should differentiate the pseudopolyps from other polypoid lesions, such as the dysplasiaassociated mass or lesion, but this situation represents an ongoing clinical challenge. Pseudopolyps can provoke complications such as bleeding or obstruction, and their management includes medical therapy, endoscopy and surgery; however, no consensus exists about the optimal treatment approach. Patients with pseudopolyps are considered at intermediate risk for colorectal cancer and regular endoscopic monitoring is recommended. Through a review of the literature, we provide here a proposed classification of the characteristics of pseudopolyps.展开更多
AIM:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. METHODS:TNBS was administered to rats at the following c...AIM:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. METHODS:TNBS was administered to rats at the following conditions:(1)with different doses(20,10,5 mg/0.8 mL per rat);(2)with same dose in different concentrations(20 mg/rat,25,50 mg/mL);(3)in different ethanol percentage(25%,50%);and(4)at depth either 4 cm or 8 cm from anus.At 5 d and 4 wk after TNBS administration,inflammation severity and inflammation resolution were evaluated.At 4 and 8 wk after TNBS application,visceral hyperalgesia and enterochromaffin(EC)cell hyperplasia were assayed by abdominal withdrawal reflex test,silver staining and capillary electrophoresis. RESULTS:Our results showed that:(1)TNBS induced dose-dependent acute inflammation and inflammation resolution.At 5 d post TNBS,the pathological score and myeloperoxidase(MPO)activity in all TNBS treated rats were significantly elevated compared to that of the control(9.48±1.86,8.18±0.67,5.78± 0.77 vs 0,and 3.55±1.11,1.80±0.82,0.97±0.08 unit/mg vs 0.14±0.01 unit/mg,P<0.05).At 4 wk post TNBS,the pathological score in high and median dose TNBS-treated rats were still significantly higher than that of the control(1.52±0.38 and 0.80±0.35 vs 0,P<0.05);(2)Intracolonic TNBS administration position affected the persistence of visceral hyperalgesia.At 4 wk post TNBS,abdominal withdrawal reflex (AWR)threshold pressure in all TNBS-treated groups were decreased compared to that of the control(21.52 ±1.73 and 27.10±1.94 mmHg vs 34.44±1.89 mmHg,P<0.05).At 8 wk post TNBS,AWR threshold pressure in 8 cm administration group was still significantly decreased(23.33±1.33 mmHg vs 36.79±2.29 mmHg,P<0.05);(3)Ethanol percentage affected the TNBS-induced inflammation severity and visceral hyperalgesia.In TNBS-25%ethanol-treated group,the pathological score and MPO activity were significantly lowered compared to that of the TNBS-50%ethanoltreated group,while AWR threshold pressure were significantly e展开更多
Reactive nodular fibrous pseudotumor(RNFP), which presents abdominal clinical manifestations and malignant radiographic results, usually requires radical resection as the treatment. However, RNFP has been recently des...Reactive nodular fibrous pseudotumor(RNFP), which presents abdominal clinical manifestations and malignant radiographic results, usually requires radical resection as the treatment. However, RNFP has been recently described as an extremely rare benign postinflammatory lesion of a reactive nature, which typically arises from the sub-serosal layer of the digestive tract or within the surrounding mesentery in association with local injury or inflammation. In addition, a postoperative diagnosis is necessary to differentiate it from the other reactive processes of the abdomen. Furthermore, RNFP shows a good prognosis without signs of recurrence or metastasis. A 16-year-old girl presented with a 3-mo history of epigastric discomfort, and auxiliary examinations suggested a malignant tumor originating from the stomach; postoperative pathology confirmed RNFP, and after a 2-year follow-up period, the patient did not display any signs of recurrence. This case highlights the importance of preoperative pathology for surgeons who may encounter similar cases.展开更多
With the introduction of new drugs, the treatment of acne vulgaris has improved dramatically;however, there remains a considerable gap between treatment outcomes and patients’ treatment goals. This study aimed to det...With the introduction of new drugs, the treatment of acne vulgaris has improved dramatically;however, there remains a considerable gap between treatment outcomes and patients’ treatment goals. This study aimed to determine whether dermatologists’ guidance on appropriate skincare for skin symptoms such as post-inflammatory erythema and post-inflammatory hyperpigmentation (PIH), which are not covered by acne treatment, leads to an improvement in patients’ skin condition and patient satisfaction. Japanese women who had completed standard treatment for acne vulgaris and those with mild symptoms not requiring treatment were included in the study. The participants received instructions about skin care at the beginning of the study, which they continued to apply for 6 weeks. At the start and end of the study, participants were examined by a dermatologist;afterward, skin measurements, including skin color, skin surface lipid content, and image analysis by VISIA<sup>®</sup> Evolution, analysis of stratum corneum obtained from the skin surface, and Skindex-16 questionnaire for assessing quality of life (QOL), were performed. The following showed significant improvements: PIH score, number of inflammatory acne lesions, and number of non-inflammatory acne lesions observed via skin examination;skin surface lipid content and values of L* and a* obtained via instrumental measurement;n number of pore, texture, red spot, and pigmented spot obtained via by image analysis;and degree of multilayer exfoliation and interleukin-1α determined by analysis of epidermal stratum corneum. QOL measurement using Skindex-16 also improved significantly. Appropriate skin care guidance following standard acne vulgaris treatment is helpful in achieving patients’ treatment goals. .展开更多
Post-inflammatory hyperpigmentation is common problem, but its treatment still remains challenging. Tranexamic acid has been used to treat or prevent excessive bleeding loss in various medical conditions. There have b...Post-inflammatory hyperpigmentation is common problem, but its treatment still remains challenging. Tranexamic acid has been used to treat or prevent excessive bleeding loss in various medical conditions. There have been some reports of the effect of oral and topical tranexamic acid for treatment of pigmented disorder. Herein we report on a case of female patient who showed improvement of PIH after oral and topical tranexamic acid administration.展开更多
Camouflage therapy has been used for permanent contour and pigmentary defects including telangiectasias, vitiligo, lentigines, nevi, atrophic scars and burn scars. The goal of the therapy is to provide new and innovat...Camouflage therapy has been used for permanent contour and pigmentary defects including telangiectasias, vitiligo, lentigines, nevi, atrophic scars and burn scars. The goal of the therapy is to provide new and innovative ways to normalize the appearance of patients with abnormalities. A variety of cosmetic techniques are used to assist these patients in making their irregularities as inconspicuous as possible. Post-inflammatory hyperpigmentation is a frustrating problem afflicting many dermatology patients, particularly on the face. Here we report a case of successful cosmetic camouflage using the theory of complementary colors of light in a patient with post-inflammatory hyperpigmentation of the face caused by fixed drug eruption. Our case report supports the idea that camouflage for patients with post-inflammatory hyperpigmentation on the face caused by fixed drug eruption improves their quality of life and also supports the idea that camouflage should be part of the after care for patients who have received patch testing.展开更多
目的探讨755 nm皮秒激光治疗雀斑伴黄褐斑的疗效及安全性。方法自2018年6月至2020年12月,中国医学科学院北京协和医学院整形外科医院激光美容中心对73例FitzpatrickⅢ、Ⅳ型雀斑伴黄褐斑患者,采用755 nm皮秒激光治疗。术前、术后3个月采...目的探讨755 nm皮秒激光治疗雀斑伴黄褐斑的疗效及安全性。方法自2018年6月至2020年12月,中国医学科学院北京协和医学院整形外科医院激光美容中心对73例FitzpatrickⅢ、Ⅳ型雀斑伴黄褐斑患者,采用755 nm皮秒激光治疗。术前、术后3个月采用VISIA分别对色斑清除的程度、黄褐斑面积和严重指数(melasma area and severity index,MASI)评分进行评估。结果73例患者获随访3个月,所有患者雀斑的平均清除评分为(2.53±0.50)分。黄褐斑MASI评分由治疗前(10.62±0.19)分降低为治疗后的(10.38±0.19)分,2例(4.8%)出现轻度炎症后色素沉着,其余患者无明显不良反应发生。结论755 nm皮秒激光是治疗雀斑伴有黄褐斑安全有效的方法,可有效去除患者皮肤的雀斑,治疗过程耐受良好,未观察到严重不良反应,同时诱发原有黄褐斑加重的风险性相对较小。展开更多
为氨甲环酸临床应用的拓宽和创新提供参考。检索中国知网、Web of Science、PubMed等数据库中近5年来与氨甲环酸非止血用途相关的文献,对氨甲环酸的功效、作用机制进行综述,并对其创新应用进行了讨论和展望。氨甲环酸由于其分子结构和...为氨甲环酸临床应用的拓宽和创新提供参考。检索中国知网、Web of Science、PubMed等数据库中近5年来与氨甲环酸非止血用途相关的文献,对氨甲环酸的功效、作用机制进行综述,并对其创新应用进行了讨论和展望。氨甲环酸由于其分子结构和抗纤溶作用,衍生出诸多功效,除了止血之外,还具有保护线粒体、抗菌、抗病毒、抗癌、延缓衰老、美白,治疗痤疮、玫瑰痤疮、黄褐斑、银屑病、炎症后色素沉着等功效。氨甲环酸在衰老、感染、癌症、皮肤等疾病的预防和治疗,以及医美项目中的应用具有巨大潜力,创新制剂和氨甲环酸衍生物的研发更有利于氨甲环酸功效的发挥。展开更多
目的探究光子嫩肤联合调Q激光治疗痤疮后色素沉着的效果。方法自2018年1月至2019年6月,河北医科大学第二医院整形外科将76例患者按照随机数字表法分为观察组和对照组,38例/组。对照组采取光子嫩肤治疗,观察组采用光子嫩肤联合调Q激光治...目的探究光子嫩肤联合调Q激光治疗痤疮后色素沉着的效果。方法自2018年1月至2019年6月,河北医科大学第二医院整形外科将76例患者按照随机数字表法分为观察组和对照组,38例/组。对照组采取光子嫩肤治疗,观察组采用光子嫩肤联合调Q激光治疗。共治疗3个月,比较两组治疗效果、治疗前后色素沉着症状评分、皮肤生理参数[角质层含水量、经皮水分丢失(trans epidermal water loss,TEWL)、pH值]、皮肤黑素指数、红斑指数及患者满意率。结果观察组有效率为94.74%高于对照组76.32%(P<0.05);观察组治疗1、2、3个月后色素程度、色素数目、色素沉着面积、情绪影响评分低于对照组(P<0.05);观察组治疗1、2、3个月后角质层含水量高于对照组,TEWL、pH值低于对照组(P<0.05);观察组治疗1、2、3个月后皮肤黑素指数、红斑指数低于对照组(P<0.05);观察组患者满意度率92.11%高于对照组70.03%(P<0.05)。结论光子嫩肤联合调Q激光治疗痤疮后色素沉着,可有效地改善患者皮肤生理功能,减轻色素沉着,提高患者满意度。展开更多
文摘Pseudopolyps are a well described entity in the literature and even though the exact pathogenesis of their formation is not completely understood, they are considered non-neoplastic lesions originating from the mucosa after repeated periods of inflammation and ulceration associated with excessive healing processes. Their occurrence is less common in Crohn's disease than in ulcerative colitis, and their overall prevalence ranges from 4% to 74%; moreover, they are found more often in colon but have been detected in other parts of the gastrointestinal tract as well. When their size exceeds the arbitrary point of 1.5 cm, they are classified as giant pseudopolyps. Clinical evaluation should differentiate the pseudopolyps from other polypoid lesions, such as the dysplasiaassociated mass or lesion, but this situation represents an ongoing clinical challenge. Pseudopolyps can provoke complications such as bleeding or obstruction, and their management includes medical therapy, endoscopy and surgery; however, no consensus exists about the optimal treatment approach. Patients with pseudopolyps are considered at intermediate risk for colorectal cancer and regular endoscopic monitoring is recommended. Through a review of the literature, we provide here a proposed classification of the characteristics of pseudopolyps.
基金Supported by Hong Kong Jockey Club Institute of Chinese Medicine,No.JCICM-4-07
文摘AIM:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. METHODS:TNBS was administered to rats at the following conditions:(1)with different doses(20,10,5 mg/0.8 mL per rat);(2)with same dose in different concentrations(20 mg/rat,25,50 mg/mL);(3)in different ethanol percentage(25%,50%);and(4)at depth either 4 cm or 8 cm from anus.At 5 d and 4 wk after TNBS administration,inflammation severity and inflammation resolution were evaluated.At 4 and 8 wk after TNBS application,visceral hyperalgesia and enterochromaffin(EC)cell hyperplasia were assayed by abdominal withdrawal reflex test,silver staining and capillary electrophoresis. RESULTS:Our results showed that:(1)TNBS induced dose-dependent acute inflammation and inflammation resolution.At 5 d post TNBS,the pathological score and myeloperoxidase(MPO)activity in all TNBS treated rats were significantly elevated compared to that of the control(9.48±1.86,8.18±0.67,5.78± 0.77 vs 0,and 3.55±1.11,1.80±0.82,0.97±0.08 unit/mg vs 0.14±0.01 unit/mg,P<0.05).At 4 wk post TNBS,the pathological score in high and median dose TNBS-treated rats were still significantly higher than that of the control(1.52±0.38 and 0.80±0.35 vs 0,P<0.05);(2)Intracolonic TNBS administration position affected the persistence of visceral hyperalgesia.At 4 wk post TNBS,abdominal withdrawal reflex (AWR)threshold pressure in all TNBS-treated groups were decreased compared to that of the control(21.52 ±1.73 and 27.10±1.94 mmHg vs 34.44±1.89 mmHg,P<0.05).At 8 wk post TNBS,AWR threshold pressure in 8 cm administration group was still significantly decreased(23.33±1.33 mmHg vs 36.79±2.29 mmHg,P<0.05);(3)Ethanol percentage affected the TNBS-induced inflammation severity and visceral hyperalgesia.In TNBS-25%ethanol-treated group,the pathological score and MPO activity were significantly lowered compared to that of the TNBS-50%ethanoltreated group,while AWR threshold pressure were significantly e
文摘Reactive nodular fibrous pseudotumor(RNFP), which presents abdominal clinical manifestations and malignant radiographic results, usually requires radical resection as the treatment. However, RNFP has been recently described as an extremely rare benign postinflammatory lesion of a reactive nature, which typically arises from the sub-serosal layer of the digestive tract or within the surrounding mesentery in association with local injury or inflammation. In addition, a postoperative diagnosis is necessary to differentiate it from the other reactive processes of the abdomen. Furthermore, RNFP shows a good prognosis without signs of recurrence or metastasis. A 16-year-old girl presented with a 3-mo history of epigastric discomfort, and auxiliary examinations suggested a malignant tumor originating from the stomach; postoperative pathology confirmed RNFP, and after a 2-year follow-up period, the patient did not display any signs of recurrence. This case highlights the importance of preoperative pathology for surgeons who may encounter similar cases.
文摘With the introduction of new drugs, the treatment of acne vulgaris has improved dramatically;however, there remains a considerable gap between treatment outcomes and patients’ treatment goals. This study aimed to determine whether dermatologists’ guidance on appropriate skincare for skin symptoms such as post-inflammatory erythema and post-inflammatory hyperpigmentation (PIH), which are not covered by acne treatment, leads to an improvement in patients’ skin condition and patient satisfaction. Japanese women who had completed standard treatment for acne vulgaris and those with mild symptoms not requiring treatment were included in the study. The participants received instructions about skin care at the beginning of the study, which they continued to apply for 6 weeks. At the start and end of the study, participants were examined by a dermatologist;afterward, skin measurements, including skin color, skin surface lipid content, and image analysis by VISIA<sup>®</sup> Evolution, analysis of stratum corneum obtained from the skin surface, and Skindex-16 questionnaire for assessing quality of life (QOL), were performed. The following showed significant improvements: PIH score, number of inflammatory acne lesions, and number of non-inflammatory acne lesions observed via skin examination;skin surface lipid content and values of L* and a* obtained via instrumental measurement;n number of pore, texture, red spot, and pigmented spot obtained via by image analysis;and degree of multilayer exfoliation and interleukin-1α determined by analysis of epidermal stratum corneum. QOL measurement using Skindex-16 also improved significantly. Appropriate skin care guidance following standard acne vulgaris treatment is helpful in achieving patients’ treatment goals. .
文摘Post-inflammatory hyperpigmentation is common problem, but its treatment still remains challenging. Tranexamic acid has been used to treat or prevent excessive bleeding loss in various medical conditions. There have been some reports of the effect of oral and topical tranexamic acid for treatment of pigmented disorder. Herein we report on a case of female patient who showed improvement of PIH after oral and topical tranexamic acid administration.
文摘Camouflage therapy has been used for permanent contour and pigmentary defects including telangiectasias, vitiligo, lentigines, nevi, atrophic scars and burn scars. The goal of the therapy is to provide new and innovative ways to normalize the appearance of patients with abnormalities. A variety of cosmetic techniques are used to assist these patients in making their irregularities as inconspicuous as possible. Post-inflammatory hyperpigmentation is a frustrating problem afflicting many dermatology patients, particularly on the face. Here we report a case of successful cosmetic camouflage using the theory of complementary colors of light in a patient with post-inflammatory hyperpigmentation of the face caused by fixed drug eruption. Our case report supports the idea that camouflage for patients with post-inflammatory hyperpigmentation on the face caused by fixed drug eruption improves their quality of life and also supports the idea that camouflage should be part of the after care for patients who have received patch testing.
文摘目的探讨755 nm皮秒激光治疗雀斑伴黄褐斑的疗效及安全性。方法自2018年6月至2020年12月,中国医学科学院北京协和医学院整形外科医院激光美容中心对73例FitzpatrickⅢ、Ⅳ型雀斑伴黄褐斑患者,采用755 nm皮秒激光治疗。术前、术后3个月采用VISIA分别对色斑清除的程度、黄褐斑面积和严重指数(melasma area and severity index,MASI)评分进行评估。结果73例患者获随访3个月,所有患者雀斑的平均清除评分为(2.53±0.50)分。黄褐斑MASI评分由治疗前(10.62±0.19)分降低为治疗后的(10.38±0.19)分,2例(4.8%)出现轻度炎症后色素沉着,其余患者无明显不良反应发生。结论755 nm皮秒激光是治疗雀斑伴有黄褐斑安全有效的方法,可有效去除患者皮肤的雀斑,治疗过程耐受良好,未观察到严重不良反应,同时诱发原有黄褐斑加重的风险性相对较小。
文摘为氨甲环酸临床应用的拓宽和创新提供参考。检索中国知网、Web of Science、PubMed等数据库中近5年来与氨甲环酸非止血用途相关的文献,对氨甲环酸的功效、作用机制进行综述,并对其创新应用进行了讨论和展望。氨甲环酸由于其分子结构和抗纤溶作用,衍生出诸多功效,除了止血之外,还具有保护线粒体、抗菌、抗病毒、抗癌、延缓衰老、美白,治疗痤疮、玫瑰痤疮、黄褐斑、银屑病、炎症后色素沉着等功效。氨甲环酸在衰老、感染、癌症、皮肤等疾病的预防和治疗,以及医美项目中的应用具有巨大潜力,创新制剂和氨甲环酸衍生物的研发更有利于氨甲环酸功效的发挥。
文摘目的探究光子嫩肤联合调Q激光治疗痤疮后色素沉着的效果。方法自2018年1月至2019年6月,河北医科大学第二医院整形外科将76例患者按照随机数字表法分为观察组和对照组,38例/组。对照组采取光子嫩肤治疗,观察组采用光子嫩肤联合调Q激光治疗。共治疗3个月,比较两组治疗效果、治疗前后色素沉着症状评分、皮肤生理参数[角质层含水量、经皮水分丢失(trans epidermal water loss,TEWL)、pH值]、皮肤黑素指数、红斑指数及患者满意率。结果观察组有效率为94.74%高于对照组76.32%(P<0.05);观察组治疗1、2、3个月后色素程度、色素数目、色素沉着面积、情绪影响评分低于对照组(P<0.05);观察组治疗1、2、3个月后角质层含水量高于对照组,TEWL、pH值低于对照组(P<0.05);观察组治疗1、2、3个月后皮肤黑素指数、红斑指数低于对照组(P<0.05);观察组患者满意度率92.11%高于对照组70.03%(P<0.05)。结论光子嫩肤联合调Q激光治疗痤疮后色素沉着,可有效地改善患者皮肤生理功能,减轻色素沉着,提高患者满意度。
