Pancreatic cancer(PC)remains one of the deadliest cancers worldwide,and has a poor,five-year survival rate of 5%.Although complete surgical resection is the only curative therapy for pancreatic cancer,less than20%of n...Pancreatic cancer(PC)remains one of the deadliest cancers worldwide,and has a poor,five-year survival rate of 5%.Although complete surgical resection is the only curative therapy for pancreatic cancer,less than20%of newly-diagnosed patients undergo surgical resection with a curative intent.Due to the lack of early symptoms and the tendency of pancreatic adenocarcinoma to invade adjacent structures or to metastasize at an early stage,many patients with pancreatic cancer already have advanced disease at the time of their diagnosis and,therefore,there is a high mortality rate.To improve the patient survival rate,early detection of PC is critical.The diagnosis of PC relies on computed tomography(CT)and/or magnetic resonance imaging(MRI)with magnetic resonance cholangiopancreatography(MRCP),or biopsy or fine-needle aspiration using endoscopic ultrasound(EUS).Although multi-detector row computed tomography currently has a major role in the evaluation of PC,MRI with MRCP facilitates better detection of tumors at an early stage by allowing a comprehensive analysis of the morphological changes of the pancreas parenchyma and pancreatic duct.The diagnosis could be improved using positron emission tomography techniques in special conditions in which CT and EUS are not completely diagnostic.It is essential for clinicians to understand the advantages and disadvantages of the various pancreatic imaging modalities in order to be able to make optimal treatment and management decisions.Our study investigates the current role and innovative techniques of pancreatic imaging focused on the detection of pancreatic cancer.展开更多
目的应用静息和负荷13N-NH3 PET心肌灌注显像（MPI）对心肌血流及储备功能进行绝对定量，以评估PET对冠状动脉微血管疾病（CMVD）的诊断价值，并为准确分型提供依据。方法前瞻性纳入2016年7月至2017年9月间23例（男16例，女7例，年龄27...目的应用静息和负荷13N-NH3 PET心肌灌注显像（MPI）对心肌血流及储备功能进行绝对定量，以评估PET对冠状动脉微血管疾病（CMVD）的诊断价值，并为准确分型提供依据。方法前瞻性纳入2016年7月至2017年9月间23例（男16例，女7例，年龄27～70岁）临床疑诊CMVD的患者，行一日法静息＋ATP负荷13N-NH3 PET MPI，使用Heartsee软件分析图像，获得心肌血流相对摄取值、绝对定量值（MBF）和冠状动脉血流储备（CFR）值。根据所获得的信息诊断或排除CMVD。结合心肌酶谱检查、心脏彩超、MRI、冠状动脉造影、CT血管成像（CTA）等结果，将确诊的CMVD患者分为不合并（1型）或合并阻塞性冠状动脉疾病型（2型）及其他类型（3型）。采用两样本t检验、单因素方差分析等分析数据。结果23例中17例确诊为CMVD（其中1型10例，2型3例，3型4例），6例排除了CMVD。CMVD组与非CMVD组患者的年龄、性别、危险因素差异均无统计学意义（均P〉0.05）；相对摄取数据中静息、负荷左室整体平均摄取值、负荷〈60%最大摄取值占左室面积的百分比组间差异有统计学意义（t值：－3.249～2.469，均P〈0.05）；所有绝对血流定量指标（包括静息及负荷状态左室整体MBF、CFR，以及最小象限MBF、CFR）组间差异均有统计学意义（t值：－8.278～－3.258，均P〈0.05）。3种类型的CMVD患者的相对摄取数据组间差异无统计学意义（F值：0.002～1.440，均P〉0.05）。绝对血流定量数据中静息、负荷左室整体MBF平均值、最小象限平均值组间差异均有统计学意义（F值：3.885～8.452，均P〈0.05）。结论PET心肌血流绝对定量可为CMVD的诊断和准确分型提供一种无创、安全、准确的检查方法。展开更多
文摘Pancreatic cancer(PC)remains one of the deadliest cancers worldwide,and has a poor,five-year survival rate of 5%.Although complete surgical resection is the only curative therapy for pancreatic cancer,less than20%of newly-diagnosed patients undergo surgical resection with a curative intent.Due to the lack of early symptoms and the tendency of pancreatic adenocarcinoma to invade adjacent structures or to metastasize at an early stage,many patients with pancreatic cancer already have advanced disease at the time of their diagnosis and,therefore,there is a high mortality rate.To improve the patient survival rate,early detection of PC is critical.The diagnosis of PC relies on computed tomography(CT)and/or magnetic resonance imaging(MRI)with magnetic resonance cholangiopancreatography(MRCP),or biopsy or fine-needle aspiration using endoscopic ultrasound(EUS).Although multi-detector row computed tomography currently has a major role in the evaluation of PC,MRI with MRCP facilitates better detection of tumors at an early stage by allowing a comprehensive analysis of the morphological changes of the pancreas parenchyma and pancreatic duct.The diagnosis could be improved using positron emission tomography techniques in special conditions in which CT and EUS are not completely diagnostic.It is essential for clinicians to understand the advantages and disadvantages of the various pancreatic imaging modalities in order to be able to make optimal treatment and management decisions.Our study investigates the current role and innovative techniques of pancreatic imaging focused on the detection of pancreatic cancer.
文摘目的应用静息和负荷13N-NH3 PET心肌灌注显像（MPI）对心肌血流及储备功能进行绝对定量，以评估PET对冠状动脉微血管疾病（CMVD）的诊断价值，并为准确分型提供依据。方法前瞻性纳入2016年7月至2017年9月间23例（男16例，女7例，年龄27～70岁）临床疑诊CMVD的患者，行一日法静息＋ATP负荷13N-NH3 PET MPI，使用Heartsee软件分析图像，获得心肌血流相对摄取值、绝对定量值（MBF）和冠状动脉血流储备（CFR）值。根据所获得的信息诊断或排除CMVD。结合心肌酶谱检查、心脏彩超、MRI、冠状动脉造影、CT血管成像（CTA）等结果，将确诊的CMVD患者分为不合并（1型）或合并阻塞性冠状动脉疾病型（2型）及其他类型（3型）。采用两样本t检验、单因素方差分析等分析数据。结果23例中17例确诊为CMVD（其中1型10例，2型3例，3型4例），6例排除了CMVD。CMVD组与非CMVD组患者的年龄、性别、危险因素差异均无统计学意义（均P〉0.05）；相对摄取数据中静息、负荷左室整体平均摄取值、负荷〈60%最大摄取值占左室面积的百分比组间差异有统计学意义（t值：－3.249～2.469，均P〈0.05）；所有绝对血流定量指标（包括静息及负荷状态左室整体MBF、CFR，以及最小象限MBF、CFR）组间差异均有统计学意义（t值：－8.278～－3.258，均P〈0.05）。3种类型的CMVD患者的相对摄取数据组间差异无统计学意义（F值：0.002～1.440，均P〉0.05）。绝对血流定量数据中静息、负荷左室整体MBF平均值、最小象限平均值组间差异均有统计学意义（F值：3.885～8.452，均P〈0.05）。结论PET心肌血流绝对定量可为CMVD的诊断和准确分型提供一种无创、安全、准确的检查方法。
