Hybrid drug delivery systems(DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybr...Hybrid drug delivery systems(DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybrid thermoresponsive DDS were fully characterized and loaded with a model drug. The in vitro drug release tests are carried out at below and above the lower critical solution temperature(LCST) of the copolymer. The results have revealed that due to the presence of small diameter(~1.3 nm) micropores at the periphery of the particles, the collapsed globules of the thermoresponsive copolymer above its LCST hinders the complete release of the drug which resulted in a reverse thermoresponsive drug release profile by the hybrid DDS.展开更多
This paper aims to fabricate over centimeter size of porous silica monolith having meso-pores with large surface area. A precursor of porous silica monolith was obtained by sintering a monolithic SiO2-poly (vinyl alco...This paper aims to fabricate over centimeter size of porous silica monolith having meso-pores with large surface area. A precursor of porous silica monolith was obtained by sintering a monolithic SiO2-poly (vinyl alcohol) (PVA) nanocomposite at 600oC-1100oC. The sintering behavior was examined by means of Raman spectroscopy and a porosimetry. The PVA of the SiO2-PVA nanocomposite was combusted below 600oC, subsequently the silica nanoparticles of the nanocomposite were sintered above 900oC. The Raman spectroscopy suggested that amorphous structure of the porous silica monolith obtained above 1000oC was similar to that of a silica glass. The BET surface area and pore radius of the porous silica monolith decreased with increasing sintering temperature. These values were tailored in the range of ca. 0-291 m2.g-1 and 5-25 nm, respectively, by controlling the sintering temperature and time. The fabricated porous-silica monolith was translucent or opaque porous-silica depending on the pore size.展开更多
Porous functionalized silica nanoparticles have attracted the interest of researchers as they are excellent carriers for antibacterial drug delivery applications.In this work,porous aminated-silica nanoparticles(SiO2-...Porous functionalized silica nanoparticles have attracted the interest of researchers as they are excellent carriers for antibacterial drug delivery applications.In this work,porous aminated-silica nanoparticles(SiO2-NH2 NPs) were prepared via one-step approach through the ammonia-catalyzed hydrolysis of tetraethylorthosilicate(TEOS) and(3-aminopropyl) triethoxysilane(APTES) in a mixed water-ethanol system.The obtained SiO2-NH2 NPs displayed a spherical morphology and relatively uniform size distribution,while the morphology and structure of SiO2-NH2 NPs were mainly determined by the order of the reagents added and the pH value of the solution.After characterization,the results showed that there were a large number of-NH2 groups on the surface of porous SiO2-NH2 NPs and that the porous SiO2-NH2 NPs had a large surface area of 476 m2 g-1 with an average pore width of 4.3 nm.Through an absorbing-releasing experiment and bacterial test,those SiO2-NH2 NPs were found to exhibit efficient absorption and release of drugs as well as a pH-de pendent release pattern of epirubicin-loaded SiO2-NH2 NPs.Meanwhile,SiO2-NH2@capsaicin NPs exhibited antibacterial properties.Those porous SiO2-NH2 NPs could be a candidate for drug delivery for antibacterial applications owing to their tailored porous structure and high surface area.展开更多
Numerous nanocarriers have been currently developed for intracellular delivery.The potential cytotoxicity of these very small inorganic nanocarriers has raised great consideration.Thus,it becomes of utmost importance ...Numerous nanocarriers have been currently developed for intracellular delivery.The potential cytotoxicity of these very small inorganic nanocarriers has raised great consideration.Thus,it becomes of utmost importance to conduct the intracellular trace of nanocarriers.Among many analytical techniques,surface enhanced Raman scattering(SERS)method is one of the current state-of-the-art techniques for cell visualization and trace.In this work,a novel stellate porous silica based gene delivery system has been designed for SERS trace purpose.A stellate porous silica nanoparticle modified with many small Au nanoparticles is designed to replace common metallic SERS tags.The results show that the designed system not only could deliver si RNA into cells for therapy,but also could realize SERS trace with high sensitivity and non-invasive features.The constructed delivery system has considerable potential to trace the dynamic gene delivery in living cells.展开更多
Pd-based egg-shell nano-catalysts were prepared using porous hollow silica nanoparticles （PHSNs） as support, and the as-prepared catalysts were modified with TiO2 to promote their selectivity for hydro-genation of a...Pd-based egg-shell nano-catalysts were prepared using porous hollow silica nanoparticles （PHSNs） as support, and the as-prepared catalysts were modified with TiO2 to promote their selectivity for hydro-genation of acetylene. Pd nanoparticles were loaded evenly on PHSNs and TiO2 was loaded on the active Pd particles. The effects of reduction time and temperature and the amount of TiO2 added on catalytic per-formances were investigated by using a fixed-bed micro-reactor. It was found that the catalysts showed better performance when reduced at 300 ℃ than at 500℃, and if reduced for 1 h than 3 h. When the amount of Ti added was 6 times that of Pd, the catalyst showed the highest ethylene selectivity.展开更多
文摘Hybrid drug delivery systems(DDS) have been prepared by grafting poly(NIPAM-co-MPS) chains on multimodal porous silica nanoparticles having an inner mesoporous structure and an outer thin layer of micropores. The hybrid thermoresponsive DDS were fully characterized and loaded with a model drug. The in vitro drug release tests are carried out at below and above the lower critical solution temperature(LCST) of the copolymer. The results have revealed that due to the presence of small diameter(~1.3 nm) micropores at the periphery of the particles, the collapsed globules of the thermoresponsive copolymer above its LCST hinders the complete release of the drug which resulted in a reverse thermoresponsive drug release profile by the hybrid DDS.
文摘This paper aims to fabricate over centimeter size of porous silica monolith having meso-pores with large surface area. A precursor of porous silica monolith was obtained by sintering a monolithic SiO2-poly (vinyl alcohol) (PVA) nanocomposite at 600oC-1100oC. The sintering behavior was examined by means of Raman spectroscopy and a porosimetry. The PVA of the SiO2-PVA nanocomposite was combusted below 600oC, subsequently the silica nanoparticles of the nanocomposite were sintered above 900oC. The Raman spectroscopy suggested that amorphous structure of the porous silica monolith obtained above 1000oC was similar to that of a silica glass. The BET surface area and pore radius of the porous silica monolith decreased with increasing sintering temperature. These values were tailored in the range of ca. 0-291 m2.g-1 and 5-25 nm, respectively, by controlling the sintering temperature and time. The fabricated porous-silica monolith was translucent or opaque porous-silica depending on the pore size.
基金supported financially by National Natural Science Foundation of China (No. 51706166 and No. 51773163)Innovation Group of Natural Science Foundation of Hubei Province (No. 2016CFA008)Joint Funds of China (No. 20171f0107)。
文摘Porous functionalized silica nanoparticles have attracted the interest of researchers as they are excellent carriers for antibacterial drug delivery applications.In this work,porous aminated-silica nanoparticles(SiO2-NH2 NPs) were prepared via one-step approach through the ammonia-catalyzed hydrolysis of tetraethylorthosilicate(TEOS) and(3-aminopropyl) triethoxysilane(APTES) in a mixed water-ethanol system.The obtained SiO2-NH2 NPs displayed a spherical morphology and relatively uniform size distribution,while the morphology and structure of SiO2-NH2 NPs were mainly determined by the order of the reagents added and the pH value of the solution.After characterization,the results showed that there were a large number of-NH2 groups on the surface of porous SiO2-NH2 NPs and that the porous SiO2-NH2 NPs had a large surface area of 476 m2 g-1 with an average pore width of 4.3 nm.Through an absorbing-releasing experiment and bacterial test,those SiO2-NH2 NPs were found to exhibit efficient absorption and release of drugs as well as a pH-de pendent release pattern of epirubicin-loaded SiO2-NH2 NPs.Meanwhile,SiO2-NH2@capsaicin NPs exhibited antibacterial properties.Those porous SiO2-NH2 NPs could be a candidate for drug delivery for antibacterial applications owing to their tailored porous structure and high surface area.
基金financially supported by the Australian Research Council(ARC)Discovery Projects(Nos.DP140104062 and DP160104866)Fundamental Research Funds for the Central Universities(Nos.FRF-TP-19-017B1,2302015-06500017,FRF-BR-19-003B,FRF-BD-20-14A)National Natural Science Foundation of China(No.21501009)。
文摘Numerous nanocarriers have been currently developed for intracellular delivery.The potential cytotoxicity of these very small inorganic nanocarriers has raised great consideration.Thus,it becomes of utmost importance to conduct the intracellular trace of nanocarriers.Among many analytical techniques,surface enhanced Raman scattering(SERS)method is one of the current state-of-the-art techniques for cell visualization and trace.In this work,a novel stellate porous silica based gene delivery system has been designed for SERS trace purpose.A stellate porous silica nanoparticle modified with many small Au nanoparticles is designed to replace common metallic SERS tags.The results show that the designed system not only could deliver si RNA into cells for therapy,but also could realize SERS trace with high sensitivity and non-invasive features.The constructed delivery system has considerable potential to trace the dynamic gene delivery in living cells.
基金the financial support provided by National Natural Science Foundation of China (Nos.20821004 and 50642042)the Key Research Program of Ministry ofEducation of China (No. 108009)+1 种基金CNPC Innovation Foundation (No.06-04D-01-01-02)the Chinese Universities Scientific Fund
文摘Pd-based egg-shell nano-catalysts were prepared using porous hollow silica nanoparticles （PHSNs） as support, and the as-prepared catalysts were modified with TiO2 to promote their selectivity for hydro-genation of acetylene. Pd nanoparticles were loaded evenly on PHSNs and TiO2 was loaded on the active Pd particles. The effects of reduction time and temperature and the amount of TiO2 added on catalytic per-formances were investigated by using a fixed-bed micro-reactor. It was found that the catalysts showed better performance when reduced at 300 ℃ than at 500℃, and if reduced for 1 h than 3 h. When the amount of Ti added was 6 times that of Pd, the catalyst showed the highest ethylene selectivity.
