Integrating poly（lactic acid） （PLA）, glycolic acid （GA） and ethylene glycol （EG） will hopefully result in a novel copolymer that combines such advantages as fastened and controllable release rate and improved ...Integrating poly（lactic acid） （PLA）, glycolic acid （GA） and ethylene glycol （EG） will hopefully result in a novel copolymer that combines such advantages as fastened and controllable release rate and improved flexibility together with good biocompatibility. In this study, p-dioxanone （PDO） was employed to copolymerize with DL-lactide （LA） via ring-opening melt polymerization using Sn（Oct）2 as an initiator and ethylene glycol as a co-initiator. The obtained degradable macrodiols （HO-P（LA-co-PDO）-OH） were just such a copolymer consisting of PLA, GA and EG. 1HNMR was employed to characterize the copolymers, and the effect of PDO/LA molar ratios in the feedstock on the molecular weights of HO-P（LA-co-PDO）-OH was investigated by means of endhydroxyl analysis, 1H NMR or GPC-MALLs. The results confirmed the successful synthesis of HO-P（LA-co-PDO）-OH and revealed that one end-hydroxyl of the micarodiols was donated by LA or PDO and the other one by the co-initiator EG. In addition, the molecular weights of HO-P（LA-co-PDO）-OH increased with decreasing PDO/LA ratios.展开更多
基金supported by the National Key Technologies R&D Program of China(No.2006BA103B04)the Natural Key Scientific and Technological Project of Chongqing(No.CSTC 2008AB0027)
文摘Integrating poly（lactic acid） （PLA）, glycolic acid （GA） and ethylene glycol （EG） will hopefully result in a novel copolymer that combines such advantages as fastened and controllable release rate and improved flexibility together with good biocompatibility. In this study, p-dioxanone （PDO） was employed to copolymerize with DL-lactide （LA） via ring-opening melt polymerization using Sn（Oct）2 as an initiator and ethylene glycol as a co-initiator. The obtained degradable macrodiols （HO-P（LA-co-PDO）-OH） were just such a copolymer consisting of PLA, GA and EG. 1HNMR was employed to characterize the copolymers, and the effect of PDO/LA molar ratios in the feedstock on the molecular weights of HO-P（LA-co-PDO）-OH was investigated by means of endhydroxyl analysis, 1H NMR or GPC-MALLs. The results confirmed the successful synthesis of HO-P（LA-co-PDO）-OH and revealed that one end-hydroxyl of the micarodiols was donated by LA or PDO and the other one by the co-initiator EG. In addition, the molecular weights of HO-P（LA-co-PDO）-OH increased with decreasing PDO/LA ratios.
