Alginate microspheres were formed by coagulation of sodium alginate in CaCl 2 solutions,followed by lyophilization which could create the porous structure.Bovine serum albumin (BSA) was incorporated into the microsphe...Alginate microspheres were formed by coagulation of sodium alginate in CaCl 2 solutions,followed by lyophilization which could create the porous structure.Bovine serum albumin (BSA) was incorporated into the microspheres by mixing BSA with sodium alginate prior to coagulation.The release behavior of BSA from the Ca-alginate microspheres was studied.Further,the alginate microspheres loaded with BSA were embedded in PLGA films by mixing the alginate microspheres with PLGA solutions in order to study the sustained release of BSA from the PLGA film,which is widely used as cell scaffold materials in tissue engineering.The release behavior of BSA from the PLGA film embedded alginate microspheres indicated potential application for keeping the bioactivity of the growth factor.展开更多
文摘Alginate microspheres were formed by coagulation of sodium alginate in CaCl 2 solutions,followed by lyophilization which could create the porous structure.Bovine serum albumin (BSA) was incorporated into the microspheres by mixing BSA with sodium alginate prior to coagulation.The release behavior of BSA from the Ca-alginate microspheres was studied.Further,the alginate microspheres loaded with BSA were embedded in PLGA films by mixing the alginate microspheres with PLGA solutions in order to study the sustained release of BSA from the PLGA film,which is widely used as cell scaffold materials in tissue engineering.The release behavior of BSA from the PLGA film embedded alginate microspheres indicated potential application for keeping the bioactivity of the growth factor.
