<strong>Purpose:</strong> <span style="font-family:""><span style="font-family:Verdana;">The study is aimed to establish the dosimetric characteristics of field-in-fiel...<strong>Purpose:</strong> <span style="font-family:""><span style="font-family:Verdana;">The study is aimed to establish the dosimetric characteristics of field-in-field (FiF) technique for carcinoma of breast treatment in Nepal. We assumed that FIF technique may result in improved dose distribution and reduced acute toxicity in these patients. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">Forty breast cancer patient</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> participated in this study. A total dose of 50 Gy in 25 fractions was prescribed to the planning target volume. FiF plan was generated in treatment planning system. Dose volume histograms w</span><span style="font-family:Verdana;">ere</span><span style="font-family:""><span style="font-family:Verdana;"> evaluated for PTV and organs at risks. Several parameters were analyzed for the PTVs and organ at risks (OARs) together with the Conformity index (CI), and the Homogeneity index (HI). </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">The dose coverage of breast volume was achieved. The V</span><sub><span style="font-family:Verdana;">95%</span></sub><span style="font-family:Verdana;"> (volume of 95%) of PTV covered D</span><sub><span style="font-family:Verdana;">95%</span></sub><span style="font-family:Verdana;"> (Dose of 95%). The PTV dose was covered to 49.98 ± 0.9 Gy and 49.81 ± 1.1 Gy for the left and right breast, respectively. The mean lung dose was 14.87 ± 0.91 Gy. The homogeneity index (0.26 ± 0.17 and 0.22 ± 0.13) and conformity index (1.59 ± 0.75 and 1.36 ± 0.45) were analyzed for left and right breast, respectively. </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">The study supports the viability of FiF technique in the treatment of breast cancer in Nepal. The FIF technique enables better dose distribution in the PTV and reduces dose to OA展开更多
<strong>Purpose:</strong><span style="font-family:""><span style="font-family:Verdana;"> The study was performed comparing dosimetric characteristics of volumetric modu...<strong>Purpose:</strong><span style="font-family:""><span style="font-family:Verdana;"> The study was performed comparing dosimetric characteristics of volumetric modulated arc therapy (VMAT) and field-in-field (FiF) techniques on a patient with synchronous bilateral breast carcinoma. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> The patients with bilateral breast cancer treatment were included in this study. A total dose of 40.05 Gy in 15 fractions was prescribed to the Planning Target Volume (PTV) of the whole bilateral breast cancer with the supraclavicular and infraclavicular nodes, with a complementary boost of 10 Gy in 4 fractions to the surgical bed (PTV</span><sub><span style="font-family:Verdana;">boost</span></sub><span style="font-family:Verdana;">). For both radiotherapy techniques, several V</span><sub><span style="font-family:Verdana;">xGy</span></sub><span style="font-family:Verdana;"> parameters were analyzed for the PTVs, together with the Conformity index (CI), the Homogeneity index (HI) and the critical organs at risk (OARs), lungs and heart. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The patient was treated by the VMAT technique and the daily treatment time was less than 20 minutes with daily CBCT imaging. In the VMAT plan, the PTV 95% dose covered 38.89 ± 0.81 Gy, compared to 37.26 ± 1.02 Gy in the FiF technique. The VMAT plan improved the dose homogeneity index and lower dose in lung towards high dose region. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The study demonstrates the viability of the VMAT technique in the treatment of bilateral breast cancer. The introduced single isocentric VMAT technique is fast to deliver and it increases the dose homogeneity of the target volume with some limitations. The treatment was well tolerated, without interruption of the treatment courses caused by treatment</span></span><span styl展开更多
文摘<strong>Purpose:</strong> <span style="font-family:""><span style="font-family:Verdana;">The study is aimed to establish the dosimetric characteristics of field-in-field (FiF) technique for carcinoma of breast treatment in Nepal. We assumed that FIF technique may result in improved dose distribution and reduced acute toxicity in these patients. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">Forty breast cancer patient</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> participated in this study. A total dose of 50 Gy in 25 fractions was prescribed to the planning target volume. FiF plan was generated in treatment planning system. Dose volume histograms w</span><span style="font-family:Verdana;">ere</span><span style="font-family:""><span style="font-family:Verdana;"> evaluated for PTV and organs at risks. Several parameters were analyzed for the PTVs and organ at risks (OARs) together with the Conformity index (CI), and the Homogeneity index (HI). </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">The dose coverage of breast volume was achieved. The V</span><sub><span style="font-family:Verdana;">95%</span></sub><span style="font-family:Verdana;"> (volume of 95%) of PTV covered D</span><sub><span style="font-family:Verdana;">95%</span></sub><span style="font-family:Verdana;"> (Dose of 95%). The PTV dose was covered to 49.98 ± 0.9 Gy and 49.81 ± 1.1 Gy for the left and right breast, respectively. The mean lung dose was 14.87 ± 0.91 Gy. The homogeneity index (0.26 ± 0.17 and 0.22 ± 0.13) and conformity index (1.59 ± 0.75 and 1.36 ± 0.45) were analyzed for left and right breast, respectively. </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">The study supports the viability of FiF technique in the treatment of breast cancer in Nepal. The FIF technique enables better dose distribution in the PTV and reduces dose to OA
文摘<strong>Purpose:</strong><span style="font-family:""><span style="font-family:Verdana;"> The study was performed comparing dosimetric characteristics of volumetric modulated arc therapy (VMAT) and field-in-field (FiF) techniques on a patient with synchronous bilateral breast carcinoma. </span><b><span style="font-family:Verdana;">Methods:</span></b><span style="font-family:Verdana;"> The patients with bilateral breast cancer treatment were included in this study. A total dose of 40.05 Gy in 15 fractions was prescribed to the Planning Target Volume (PTV) of the whole bilateral breast cancer with the supraclavicular and infraclavicular nodes, with a complementary boost of 10 Gy in 4 fractions to the surgical bed (PTV</span><sub><span style="font-family:Verdana;">boost</span></sub><span style="font-family:Verdana;">). For both radiotherapy techniques, several V</span><sub><span style="font-family:Verdana;">xGy</span></sub><span style="font-family:Verdana;"> parameters were analyzed for the PTVs, together with the Conformity index (CI), the Homogeneity index (HI) and the critical organs at risk (OARs), lungs and heart. </span><b><span style="font-family:Verdana;">Results:</span></b><span style="font-family:Verdana;"> The patient was treated by the VMAT technique and the daily treatment time was less than 20 minutes with daily CBCT imaging. In the VMAT plan, the PTV 95% dose covered 38.89 ± 0.81 Gy, compared to 37.26 ± 1.02 Gy in the FiF technique. The VMAT plan improved the dose homogeneity index and lower dose in lung towards high dose region. </span><b><span style="font-family:Verdana;">Conclusion:</span></b><span style="font-family:Verdana;"> The study demonstrates the viability of the VMAT technique in the treatment of bilateral breast cancer. The introduced single isocentric VMAT technique is fast to deliver and it increases the dose homogeneity of the target volume with some limitations. The treatment was well tolerated, without interruption of the treatment courses caused by treatment</span></span><span styl
