Parkinson's disease(PD) is the second most common neurodegenerative disease and is typically associated with progressive motor and non-motor dysfunctions.Currently, dopamine replacement therapy is mainly used to r...Parkinson's disease(PD) is the second most common neurodegenerative disease and is typically associated with progressive motor and non-motor dysfunctions.Currently, dopamine replacement therapy is mainly used to relieve the motor symptoms, while its long-term application can lead to various complications and does not cure the disease. Numerous studies have demonstrated that many brain-gut peptides have neuroprotective effects in vivo and in vitro, and may be a promising treatment for PD. In recent years, some progress has been made in studies on the neuroprotective effects of some newly-discovered braingut peptides, such as glucagon-like peptide 1, pituitary adenylate cyclase activating polypeptide, nesfatin-1, and ghrelin. However, there is still no systematic review on the neuroprotective effects common to these peptides. Thus,here we review the neuroprotective effects and the associated mechanisms of these four peptides, as well as other brain-gut peptides related to PD, in the hope of providing new ideas for the treatment of PD and related clinical research.展开更多
目的分析以尿崩症为首发表现的垂体转移性肿瘤(PM)患者的临床特征,以期提高对PM与尿崩症关系的认识,避免误诊与漏诊。方法选取2016年11月安徽医科大学第一附属医院内分泌科收治的1例以尿崩症为首发表现的肺癌伴垂体转移患者为研究对象。...目的分析以尿崩症为首发表现的垂体转移性肿瘤(PM)患者的临床特征,以期提高对PM与尿崩症关系的认识,避免误诊与漏诊。方法选取2016年11月安徽医科大学第一附属医院内分泌科收治的1例以尿崩症为首发表现的肺癌伴垂体转移患者为研究对象。以"pituitar*/hypophys*""metasta*""diabetes insipidus""垂体""转移""尿崩症"为关键词,检索Pub Med、ISI Web of Knowledge、中国知网、万方数据知识服务平台,检索时间限定为1990年1月—2017年10月,筛选报道以尿崩症为首发表现病例的文献并结合本院收治1例患者的临床资料进行回顾性分析。结果检索并筛选得到符合标准的文献31篇,患者41例,结合本例共42例,其中男24例、女18例;平均年龄(56.6±12.7)岁;患者原发病均为恶性肿瘤,其中41例患者经病理学检查确诊,1例患者经胸部CT结合血清肿瘤标志物检查诊断为肺癌。PM主要临床表现为多尿、烦渴、头痛。影像学检查发现41例患者有明确的鞍区占位,29例患者存在2个以上部位肿瘤转移;26例患者腺垂体激素分泌不足;11例患者电解质平衡紊乱。42例患者预后均较差,中位生存时间为6.0个月,1年、3年累积生存率分别为22.1%、17.7%。结论 PM是一种少见且预后较差的肿瘤相关并发症,尿崩症可作为PM患者的首发表现,甚至唯一症状。对于新近发生尿崩症的中老年患者,应积极寻找病因,重视系统性疾病的影响并考虑肿瘤垂体转移可能。展开更多
Celiac disease(CD) is an autoimmune small intestinal mucosal disorder that often presents with diarrhea, malabsorption and weight loss. Often, one or more associated endocrine disorders may be associated with CD. For ...Celiac disease(CD) is an autoimmune small intestinal mucosal disorder that often presents with diarrhea, malabsorption and weight loss. Often, one or more associated endocrine disorders may be associated with CD. For this review, methods involved an extensive review of published English-language materials. In children and adolescents, prospective studies have demonstrated a significant relationship to insulindependent or type 1 diabetes, whereas in adults, autoimmune forms of thyroid disease, particularly hypothyroidism, may commonly co-exist. In some with CD, multiple glandular endocrinopathies may also occur and complicate the initial presentation of the intestinal disease. In others presenting with an apparent isolated endocrine disorder, serological screening for underlying subclinical CD may prove to be positive, particularly if type 1 diabetes, autoimmune thyroid or other autoimmune endocrine diseases, such as Addison's disease are first detected. A number of reports have also recorded hypoparathyroidism or hypopituitarism or ovarian failure in CD and these may be improved with a strict gluten-free diet.展开更多
基金supported by grants from the National Natural Science Foundation of China (31571054 and 81430024)the Excellent Innovative Team of Shandong Province and Taishan Scholars Construction Project, China
文摘Parkinson's disease(PD) is the second most common neurodegenerative disease and is typically associated with progressive motor and non-motor dysfunctions.Currently, dopamine replacement therapy is mainly used to relieve the motor symptoms, while its long-term application can lead to various complications and does not cure the disease. Numerous studies have demonstrated that many brain-gut peptides have neuroprotective effects in vivo and in vitro, and may be a promising treatment for PD. In recent years, some progress has been made in studies on the neuroprotective effects of some newly-discovered braingut peptides, such as glucagon-like peptide 1, pituitary adenylate cyclase activating polypeptide, nesfatin-1, and ghrelin. However, there is still no systematic review on the neuroprotective effects common to these peptides. Thus,here we review the neuroprotective effects and the associated mechanisms of these four peptides, as well as other brain-gut peptides related to PD, in the hope of providing new ideas for the treatment of PD and related clinical research.
文摘目的分析以尿崩症为首发表现的垂体转移性肿瘤(PM)患者的临床特征,以期提高对PM与尿崩症关系的认识,避免误诊与漏诊。方法选取2016年11月安徽医科大学第一附属医院内分泌科收治的1例以尿崩症为首发表现的肺癌伴垂体转移患者为研究对象。以"pituitar*/hypophys*""metasta*""diabetes insipidus""垂体""转移""尿崩症"为关键词,检索Pub Med、ISI Web of Knowledge、中国知网、万方数据知识服务平台,检索时间限定为1990年1月—2017年10月,筛选报道以尿崩症为首发表现病例的文献并结合本院收治1例患者的临床资料进行回顾性分析。结果检索并筛选得到符合标准的文献31篇,患者41例,结合本例共42例,其中男24例、女18例;平均年龄(56.6±12.7)岁;患者原发病均为恶性肿瘤,其中41例患者经病理学检查确诊,1例患者经胸部CT结合血清肿瘤标志物检查诊断为肺癌。PM主要临床表现为多尿、烦渴、头痛。影像学检查发现41例患者有明确的鞍区占位,29例患者存在2个以上部位肿瘤转移;26例患者腺垂体激素分泌不足;11例患者电解质平衡紊乱。42例患者预后均较差,中位生存时间为6.0个月,1年、3年累积生存率分别为22.1%、17.7%。结论 PM是一种少见且预后较差的肿瘤相关并发症,尿崩症可作为PM患者的首发表现,甚至唯一症状。对于新近发生尿崩症的中老年患者,应积极寻找病因,重视系统性疾病的影响并考虑肿瘤垂体转移可能。
文摘Celiac disease(CD) is an autoimmune small intestinal mucosal disorder that often presents with diarrhea, malabsorption and weight loss. Often, one or more associated endocrine disorders may be associated with CD. For this review, methods involved an extensive review of published English-language materials. In children and adolescents, prospective studies have demonstrated a significant relationship to insulindependent or type 1 diabetes, whereas in adults, autoimmune forms of thyroid disease, particularly hypothyroidism, may commonly co-exist. In some with CD, multiple glandular endocrinopathies may also occur and complicate the initial presentation of the intestinal disease. In others presenting with an apparent isolated endocrine disorder, serological screening for underlying subclinical CD may prove to be positive, particularly if type 1 diabetes, autoimmune thyroid or other autoimmune endocrine diseases, such as Addison's disease are first detected. A number of reports have also recorded hypoparathyroidism or hypopituitarism or ovarian failure in CD and these may be improved with a strict gluten-free diet.
