Synthesis and characterization of tungsten based mixed valence state nanoparticles and their novel applications are reviewed.The mixed valence state tungsten based homogeneous nanomaterials such as bronze structure M_...Synthesis and characterization of tungsten based mixed valence state nanoparticles and their novel applications are reviewed.The mixed valence state tungsten based homogeneous nanomaterials such as bronze structure M_(x)WO_(3)(M=Na^(+),K^(+),Rb^(+),Cs^(+),NH_(4)^(+),etc.)and tungsten sub-oxide W_(18)O_(49) possess excellent infrared(IR)light shielding property,implying their great potential applications on heat ray shielding and indoor energy saving effect in summer season.Also,some novel properties such as electric conductivity,bio thermal therapy function and electrochromic properties of mixed valence state tungsten based materials are introduced.The design of components,formation of composites and structure control of thin films are expected to realize the property enhancement and candidates for practice application as window materials.The multifunc-tionality of the mixed valence state based composites also implies great potential on novel applications of various building materials.展开更多
Photothermal therapy (PTT), which utilizes light radiation to create localized heating effect in the targeted areas, is a promising solution for highly specific yet minimally invasive cancer therapy. PTT uses photothe...Photothermal therapy (PTT), which utilizes light radiation to create localized heating effect in the targeted areas, is a promising solution for highly specific yet minimally invasive cancer therapy. PTT uses photothermal agents, which are usually nanoparticles that absorb strongly in the near-infrared optical window where minimal tissue absorption occurs. Photothermal agents are also highly functionalized to target at specific tumor sites. Gold nanostar is an ideal candidate for photothermal agents, because it not only has a Surface Plasmon Resonance in the near-infrared, but also can be easily produced and purified, and is extremely versatile in the drug delivery process. In order to achieve maximum amount of localized heating, pulse lasers are usually used in laser ablation processes like photothermal therapy. However, intensive laser radiation can cause damage to regular tissues as well the nanostructures themselves. Therefore, identifying the optimal pulse duration to effectively generate localized heating in the tumorous tissues while keeping the normal tissues and the nanostructures intact is important to achieving optimal photo-therapeutic results. This manuscript provides a numerical calculation method with Comsol Multiphysics to optimize the pulse condition of the gold nanostars under photothermal therapy settings. Based on results, gold nanostar displays significant temperature heterogeneity under femtosecond and picosecond laser radiation, while nanosecond laser only induces rather uniform heating effects across the entire gold nanostar particle. This finding indicates that femtosecond laser, which is the most common type of laser used for ablation, is likely to melt the tip of the gold nanostar before the nanostar body reaches a reasonably high temperature. Picosecond and nanosecond lasers are much less likely to induce such dramatic morphology change. This study offers important insight into finding the optimal condition for photothermal therapy with maximal efficacy and minimal damage.展开更多
Regulation of cell behaviors and even cell fates is of great significance in diverse biomedical applications such as cancer treatment,cell-based therapy,and tissue engineering.During the past decades,diverse methods h...Regulation of cell behaviors and even cell fates is of great significance in diverse biomedical applications such as cancer treatment,cell-based therapy,and tissue engineering.During the past decades,diverse methods have been developed to regulate cell behaviors such as applying external stimuli,delivering exogenous molecules into cell interior and changing the physicochemical properties of the substrates where cells adhere.Photothermal scaffolds/surfaces refer to a kind of materials embedded or coated with photothermal agents that can absorb light with proper wavelength(usually in near infrared region)and convert light energy to heat;the generated heat shows great potential for regulation of cell behaviors in different ways.In the current review,we summarize the recent research progress,especially over the past decade,of using photothermal scaffolds/surfaces to regulate cell behaviors,which could be further categorized into three types:(i)killing the tumor cells via hyperthermia or thermal ablation,(ii)engineering cells by intracellular delivery of exogenous molecules via photothermal poration of cell membranes,and(iii)releasing a single cell or an intact cell sheet via modulation of surface physicochemical properties in response to heat.In the end,challenges and perspectives in these areas are commented.展开更多
Besides conventional surgery, radiation therapy, and chemotherapy, which all tend to have side-effects and damage normal tissues, new medical strategies, such as photothermal sensitization and photo-thermal ablation t...Besides conventional surgery, radiation therapy, and chemotherapy, which all tend to have side-effects and damage normal tissues, new medical strategies, such as photothermal sensitization and photo-thermal ablation therapy (PTA) with near-IR laser light, have been explored for treating cancer. Much of the current excitement surrounding nanoscience is directly connected to the promise of new nanotechnology for cancer diagnosis and therapy. The basic principle behind PTA is that heat generated from light can be used to destroy cancer cells. Strong optical absorption and high efficiency of photothermal conversion at the cancer sites are critical to the success of PTA. Because of their unique optical properties, e.g., strong surface plasmon resonance (SPR) absorption, noble metal nanomaterials, such as gold and silver, have been found to significantly enhance photothermal conversion for PTA applications. Substantial effort has been made to develop metal nanostructures with optimal structural and photothermal properties. Ideal metal nanostructures should have strong and tunable SPR, be easy to deliver, have low toxicity, and be convenient for bioconjugation for actively targeting specific cancer cells. This review would highlight some gold nanostructures with various shapes and properties, including nanoparticles (NPs), nanorods (NRs), nanoshells, nanocages, and hollow nanospheres, which have been studied for PTA applications. Among these structures, hollow gold nanospheres (HGNs) exhibit arguably the best combined properties because of their small size (30―50 nm), spherical shape, and strong, narrow, and tunable SPR absorption.展开更多
Copper sulfide nanoparticles(CuS NPs)have shown great potential in various application fields,especially in biomedical engineering fields.CuS NPs,with the ability to actively capture and kill bacteria and without the ...Copper sulfide nanoparticles(CuS NPs)have shown great potential in various application fields,especially in biomedical engineering fields.CuS NPs,with the ability to actively capture and kill bacteria and without the worry of biocompatibility,will greatly expand their applications.Herein,a four-arm star thermosensitive polyisopropylacrylamide(4sPNIPAm)was used to modify CuS NPs(CuS-PNIPAm NPs).The obtained NPs displayed the controlled release of copper ions and higher photothermal conversion ability in comparison with contrast materials CuS-PEG NPs and CuS NPs.Aggregation of CuS-PNIPAm NPs at above 34℃resulted in capturing bacteria by forming the aggregates of NPs-bacteria.Both Staphylococcus aureus and Escherichia coli co-cultured with CuS-PNIPAm NPs were completely killed upon near-infrared irradiation in minutes.Furthermore,CuS-PNIPAm NPs were verified to be a photothermal agent without toxic effect.In in vivo experiment,the NPs effectively killed the bacteria in the wound and accelerated the process of wound repairment.Overall,photothermal treatment by CuS-PNIPAm NPs demonstrates the ability to actively capture and kill bacteria,and has a potential in the treatment of infected skin and the regeneration of skin tissues.The therapy will exert a far-reaching impact on the regeneration of stubborn chronic wounds.展开更多
基金This research was partly supported by Japan Society for the Promotion of Science KAKENHI(Grant Number JP16H06439,Grant-in-Aid for Scientific Research on Innovative Areas)the Dynamic Alliance for Open Innovations Bridging Human,Environment and Materials,the Cooperative Research Program of Network Joint Research Center for Materials and Devices and the Hosokawa Powder Technology Foundation.
文摘Synthesis and characterization of tungsten based mixed valence state nanoparticles and their novel applications are reviewed.The mixed valence state tungsten based homogeneous nanomaterials such as bronze structure M_(x)WO_(3)(M=Na^(+),K^(+),Rb^(+),Cs^(+),NH_(4)^(+),etc.)and tungsten sub-oxide W_(18)O_(49) possess excellent infrared(IR)light shielding property,implying their great potential applications on heat ray shielding and indoor energy saving effect in summer season.Also,some novel properties such as electric conductivity,bio thermal therapy function and electrochromic properties of mixed valence state tungsten based materials are introduced.The design of components,formation of composites and structure control of thin films are expected to realize the property enhancement and candidates for practice application as window materials.The multifunc-tionality of the mixed valence state based composites also implies great potential on novel applications of various building materials.
文摘Photothermal therapy (PTT), which utilizes light radiation to create localized heating effect in the targeted areas, is a promising solution for highly specific yet minimally invasive cancer therapy. PTT uses photothermal agents, which are usually nanoparticles that absorb strongly in the near-infrared optical window where minimal tissue absorption occurs. Photothermal agents are also highly functionalized to target at specific tumor sites. Gold nanostar is an ideal candidate for photothermal agents, because it not only has a Surface Plasmon Resonance in the near-infrared, but also can be easily produced and purified, and is extremely versatile in the drug delivery process. In order to achieve maximum amount of localized heating, pulse lasers are usually used in laser ablation processes like photothermal therapy. However, intensive laser radiation can cause damage to regular tissues as well the nanostructures themselves. Therefore, identifying the optimal pulse duration to effectively generate localized heating in the tumorous tissues while keeping the normal tissues and the nanostructures intact is important to achieving optimal photo-therapeutic results. This manuscript provides a numerical calculation method with Comsol Multiphysics to optimize the pulse condition of the gold nanostars under photothermal therapy settings. Based on results, gold nanostar displays significant temperature heterogeneity under femtosecond and picosecond laser radiation, while nanosecond laser only induces rather uniform heating effects across the entire gold nanostar particle. This finding indicates that femtosecond laser, which is the most common type of laser used for ablation, is likely to melt the tip of the gold nanostar before the nanostar body reaches a reasonably high temperature. Picosecond and nanosecond lasers are much less likely to induce such dramatic morphology change. This study offers important insight into finding the optimal condition for photothermal therapy with maximal efficacy and minimal damage.
基金supported by the National Natural Science Foundation of China(21774086 and 81671742)the Natural Science Foundation of Jiangsu Province(BK20180093)+1 种基金the Suzhou Municipal Science and Technology Foundation(SYS2018026)the Start-Up Grant of Jining Medical University(600910001).
文摘Regulation of cell behaviors and even cell fates is of great significance in diverse biomedical applications such as cancer treatment,cell-based therapy,and tissue engineering.During the past decades,diverse methods have been developed to regulate cell behaviors such as applying external stimuli,delivering exogenous molecules into cell interior and changing the physicochemical properties of the substrates where cells adhere.Photothermal scaffolds/surfaces refer to a kind of materials embedded or coated with photothermal agents that can absorb light with proper wavelength(usually in near infrared region)and convert light energy to heat;the generated heat shows great potential for regulation of cell behaviors in different ways.In the current review,we summarize the recent research progress,especially over the past decade,of using photothermal scaffolds/surfaces to regulate cell behaviors,which could be further categorized into three types:(i)killing the tumor cells via hyperthermia or thermal ablation,(ii)engineering cells by intracellular delivery of exogenous molecules via photothermal poration of cell membranes,and(iii)releasing a single cell or an intact cell sheet via modulation of surface physicochemical properties in response to heat.In the end,challenges and perspectives in these areas are commented.
文摘Besides conventional surgery, radiation therapy, and chemotherapy, which all tend to have side-effects and damage normal tissues, new medical strategies, such as photothermal sensitization and photo-thermal ablation therapy (PTA) with near-IR laser light, have been explored for treating cancer. Much of the current excitement surrounding nanoscience is directly connected to the promise of new nanotechnology for cancer diagnosis and therapy. The basic principle behind PTA is that heat generated from light can be used to destroy cancer cells. Strong optical absorption and high efficiency of photothermal conversion at the cancer sites are critical to the success of PTA. Because of their unique optical properties, e.g., strong surface plasmon resonance (SPR) absorption, noble metal nanomaterials, such as gold and silver, have been found to significantly enhance photothermal conversion for PTA applications. Substantial effort has been made to develop metal nanostructures with optimal structural and photothermal properties. Ideal metal nanostructures should have strong and tunable SPR, be easy to deliver, have low toxicity, and be convenient for bioconjugation for actively targeting specific cancer cells. This review would highlight some gold nanostructures with various shapes and properties, including nanoparticles (NPs), nanorods (NRs), nanoshells, nanocages, and hollow nanospheres, which have been studied for PTA applications. Among these structures, hollow gold nanospheres (HGNs) exhibit arguably the best combined properties because of their small size (30―50 nm), spherical shape, and strong, narrow, and tunable SPR absorption.
基金supported by the National Natural Science Foundation of China(no.51973130)by the International Cooperation and Exchange in Science and Technology Research Project of Sichuan Province(2021YFH0087).
文摘Copper sulfide nanoparticles(CuS NPs)have shown great potential in various application fields,especially in biomedical engineering fields.CuS NPs,with the ability to actively capture and kill bacteria and without the worry of biocompatibility,will greatly expand their applications.Herein,a four-arm star thermosensitive polyisopropylacrylamide(4sPNIPAm)was used to modify CuS NPs(CuS-PNIPAm NPs).The obtained NPs displayed the controlled release of copper ions and higher photothermal conversion ability in comparison with contrast materials CuS-PEG NPs and CuS NPs.Aggregation of CuS-PNIPAm NPs at above 34℃resulted in capturing bacteria by forming the aggregates of NPs-bacteria.Both Staphylococcus aureus and Escherichia coli co-cultured with CuS-PNIPAm NPs were completely killed upon near-infrared irradiation in minutes.Furthermore,CuS-PNIPAm NPs were verified to be a photothermal agent without toxic effect.In in vivo experiment,the NPs effectively killed the bacteria in the wound and accelerated the process of wound repairment.Overall,photothermal treatment by CuS-PNIPAm NPs demonstrates the ability to actively capture and kill bacteria,and has a potential in the treatment of infected skin and the regeneration of skin tissues.The therapy will exert a far-reaching impact on the regeneration of stubborn chronic wounds.
