Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy ...Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure problem still remains. This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment.展开更多
Collagen homeostasis is critical to lung and bone stability and collagen degradation may play a role in lung and bone development,growth,and disease.Mice have two major collagenases,collagenase-2(MMP8)and collagenase-...Collagen homeostasis is critical to lung and bone stability and collagen degradation may play a role in lung and bone development,growth,and disease.Mice have two major collagenases,collagenase-2(MMP8)and collagenase-3(MMP13).To determine the roles of these collagenases we generated mice deficient in both MMP8 and MMP13.Although we had previously generated展开更多
文摘Anticancer drugs research and development have been the largest market area in the pharmaceutical industry in terms of the number of project, clinical trials and spending. In the last 10 - 30 years, targeting therapy for cancers has been developed and achieved enormous clinical effectiveness by transforming some previously deadly malignancies into chronically manageable conditions, but cure problem still remains. This mini review outlined the current status of anticancer drugs development and hinted the opinions of how to further increase the accuracy and efficacy of discovery for cancer treatment.
文摘Collagen homeostasis is critical to lung and bone stability and collagen degradation may play a role in lung and bone development,growth,and disease.Mice have two major collagenases,collagenase-2(MMP8)and collagenase-3(MMP13).To determine the roles of these collagenases we generated mice deficient in both MMP8 and MMP13.Although we had previously generated
