Background: Although hypovitaminosis D is prevalent among healthy adults in Asia and other regions, available data among Sri Lankans are not consistent with this finding. We studied vitamin D level among healthy commu...Background: Although hypovitaminosis D is prevalent among healthy adults in Asia and other regions, available data among Sri Lankans are not consistent with this finding. We studied vitamin D level among healthy community-dwelling women and examined its effects on parathyroid hormone (PTH) level and bone mineral status. Methods: Females of 20-40 years (n = 434) who were employed in southern Sri Lanka were recruited to the study. Bone mineral density and content (pBMD and pBMC) of the middle phalanx of the middle finger of the non-dominant hand were measured in all subjects and 5.0 ml of venous blood was collected from each subject after an overnight fast for biochemical assessment of serum vitamin D, parathyroid hormone and total alkaline phosphatase. Results: Mean (SD) pBMD of the women studied was 0.493 (0.060) g/cm2 and pBMC was 1.49 (0.28) g. Severe vitamin D deficiency (jects, whereas 19.1% subjects had moderate (12.5-25.0 nmol/L) and 15.7% had mild (25.1 -35.0 nmol/L) vitamin D deficiency. Serum vitamin D showed significant positive correlations with pBMD (r = 0.13, p = 0.008) and pBMC (r = 0.12, p = 0.01). In regression analysis, vitamin D showed a positive association with pBMD (regression coefficient 0.0003, SEM 0.0001, p = 0.007). Conclusions: Vitamin D insufficiency/deficiency is prevalent among healthy young and middle-aged women in this study group selected from southern Sri Lanka. The accompanying rise of PTH indicates the biological significance of low vitamin D level. The negative effects observed on bone mineral status suggest the clinical importance of this finding.展开更多
目的掌指骨骨折是手外科常见创伤性疾病,掌指骨参与腕掌、掌指、指间关节的构成,治疗不当将严重影响患者的手的功能。文中探讨微型钢板、穿髓克氏针固定、牵引位石膏托3种不同治疗方法在掌指骨骨折治疗中的临床疗效。方法选取掌指骨骨...目的掌指骨骨折是手外科常见创伤性疾病,掌指骨参与腕掌、掌指、指间关节的构成,治疗不当将严重影响患者的手的功能。文中探讨微型钢板、穿髓克氏针固定、牵引位石膏托3种不同治疗方法在掌指骨骨折治疗中的临床疗效。方法选取掌指骨骨折患者60例共95个部位,分别平均进入微型钢板内固定、穿髓克氏针固定及牵引位石膏托3种不同治疗方法组,术后随访6～12个月,平均随访(8.1±1.5)个月,按照总主动屈曲度系统(total active flexion system,TAFS)评分评估3组临床疗效。结果微型钢板组内固定优良率为90.9%,穿髓克氏针内固定组优良率为71.4%,牵引位石膏保守治疗组优良率为55.6%,3组结果差异有显著统计学意义(P<0.05)。骨折愈合时间微型钢板组较其他2组短,差异有统计学意义(P<0.05)。切开复位感染率微型钢板内固定组为0.0%,穿髓克氏针组为15.4%(P<0.05)。结论微型钢板内固定治疗掌指骨骨折在术后关节功能恢复、骨折愈合时间、术后感染预防方面都具有明显优势,是首选的治疗方法。展开更多
文摘Background: Although hypovitaminosis D is prevalent among healthy adults in Asia and other regions, available data among Sri Lankans are not consistent with this finding. We studied vitamin D level among healthy community-dwelling women and examined its effects on parathyroid hormone (PTH) level and bone mineral status. Methods: Females of 20-40 years (n = 434) who were employed in southern Sri Lanka were recruited to the study. Bone mineral density and content (pBMD and pBMC) of the middle phalanx of the middle finger of the non-dominant hand were measured in all subjects and 5.0 ml of venous blood was collected from each subject after an overnight fast for biochemical assessment of serum vitamin D, parathyroid hormone and total alkaline phosphatase. Results: Mean (SD) pBMD of the women studied was 0.493 (0.060) g/cm2 and pBMC was 1.49 (0.28) g. Severe vitamin D deficiency (jects, whereas 19.1% subjects had moderate (12.5-25.0 nmol/L) and 15.7% had mild (25.1 -35.0 nmol/L) vitamin D deficiency. Serum vitamin D showed significant positive correlations with pBMD (r = 0.13, p = 0.008) and pBMC (r = 0.12, p = 0.01). In regression analysis, vitamin D showed a positive association with pBMD (regression coefficient 0.0003, SEM 0.0001, p = 0.007). Conclusions: Vitamin D insufficiency/deficiency is prevalent among healthy young and middle-aged women in this study group selected from southern Sri Lanka. The accompanying rise of PTH indicates the biological significance of low vitamin D level. The negative effects observed on bone mineral status suggest the clinical importance of this finding.
文摘目的掌指骨骨折是手外科常见创伤性疾病,掌指骨参与腕掌、掌指、指间关节的构成,治疗不当将严重影响患者的手的功能。文中探讨微型钢板、穿髓克氏针固定、牵引位石膏托3种不同治疗方法在掌指骨骨折治疗中的临床疗效。方法选取掌指骨骨折患者60例共95个部位,分别平均进入微型钢板内固定、穿髓克氏针固定及牵引位石膏托3种不同治疗方法组,术后随访6～12个月,平均随访(8.1±1.5)个月,按照总主动屈曲度系统(total active flexion system,TAFS)评分评估3组临床疗效。结果微型钢板组内固定优良率为90.9%,穿髓克氏针内固定组优良率为71.4%,牵引位石膏保守治疗组优良率为55.6%,3组结果差异有显著统计学意义(P<0.05)。骨折愈合时间微型钢板组较其他2组短,差异有统计学意义(P<0.05)。切开复位感染率微型钢板内固定组为0.0%,穿髓克氏针组为15.4%(P<0.05)。结论微型钢板内固定治疗掌指骨骨折在术后关节功能恢复、骨折愈合时间、术后感染预防方面都具有明显优势,是首选的治疗方法。
