An approach for the integrated optimization of the construction/expansion capacity of high-voltage/ medium-voltage (HV/MV) substations and the configuration of MV radial distribution network was presented using plant ...An approach for the integrated optimization of the construction/expansion capacity of high-voltage/ medium-voltage (HV/MV) substations and the configuration of MV radial distribution network was presented using plant growth simulation algorithm (PGSA). In the optimization process, fixed costs correspondent to the investment in lines and substations and the variable costs associated to the operation of the system were considered under the constraints of branch capacity, substation capacity and bus voltage. The optimization variables considerably reduce the dimension of variables and speed up the process of optimizing. The effectiveness of the proposed approach was tested by a distribution system planning.展开更多
This paper is to provide a novel approach for the spatial aggregation of judgment matrices.The optimal aggregation method of judgment matrices based on spatial Steiner-Weber point can effectively aggregate the prefere...This paper is to provide a novel approach for the spatial aggregation of judgment matrices.The optimal aggregation method of judgment matrices based on spatial Steiner-Weber point can effectively aggregate the preference information of group members and achieve the optimization of group preference.The method comprises three key elements:The spatial mapping of the judgment matrices,the spatial optimal aggregation model of the judgment matrices,and the plant growth simulation algorithm(PGSA)is used to find the optimal aggregation points.Firstly,the judgment matrices are mapped into a set of spatial multidimensional coordinates by using spatial mapping rules.Secondly,the spatial Steiner-Weber point is used as the prototype to construct the spatial aggregation model.Thirdly,the PGSA algorithm is used to find the spatial aggregation points,whose spatial weighted Euclidean distance to all the decision makers’preference points is minimal.The optimal aggregation matrix is composed of these optimal aggregation points,which can accurately reflect the decision maker's comprehensive opinions.Finally,the effectiveness and rationality of this method are verified by comparing with the classical group preference aggregation methods.展开更多
P-Coumaric acid was previously reported to contain antioxidant,antidiabetic,anti-inflammatory,antiplatelet,antiulcer and anticancer activities.Along with these,the present work has been conducted to study the antibact...P-Coumaric acid was previously reported to contain antioxidant,antidiabetic,anti-inflammatory,antiplatelet,antiulcer and anticancer activities.Along with these,the present work has been conducted to study the antibacterial activity of p-coumaric acid.It could be used to control broad-spectrum microbiome-based inflammation or in cancer control.HPLC analysis of methanolic extract from the mushroom Termitomyces heimii has exhibited a rich fraction of p-coumaric acid(p-CA),which in the pure form showed significant bactericidal potentials.To predict the molecular interactions associated with the bactericidal mechanism of p-CA,the transmembrane protein sequences of Staphylococcus aureus and Escherichia coli were retrieved from the IMG–JGI database,screened and then aligned using Clustal X2 and PHYLIP 3.69 softwares.The common sequences were subjected to tertiary structure prediction using Phyre2 server,followed by quality assessment through the Ramachandran plot.Next,the 3D molecular structure of p-CA was downloaded from PubChem and docked with the selected tertiary structures using Patchdock and showed higher affinity towards 12 common transmembrane protein structures,amongst which CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyl transferase(PgsA)exhibited best dock-ing with p-CA on the basis of ACE value(–249 kcal/mol).This fact revealed that p-CA can block the normal functioning of membrane-bound enzyme PgsA,consequently leading to the interruption in the synthesis and recycling of an essential membrane component phosphatidylglycerol(PG),resulting in membrane disruption followed by cell lysis.Here,for the first time we reported the molecular insights and fundamental biochemical events underlying the bactericidal action by p-CA,to explore new perspective to combat multidrug-resistant bacteria.展开更多
基金the National Natural Science Foundation of China (No. 50747025)the Postdoctoral Science Foundation of China (No. 20060400648)+1 种基金the Scientific Research Foundation for the Returned Overseas Chinese Scholars (No. 2005383)the Shanghai Key Scienceand Technology Research Program (No. 041612012)
文摘An approach for the integrated optimization of the construction/expansion capacity of high-voltage/ medium-voltage (HV/MV) substations and the configuration of MV radial distribution network was presented using plant growth simulation algorithm (PGSA). In the optimization process, fixed costs correspondent to the investment in lines and substations and the variable costs associated to the operation of the system were considered under the constraints of branch capacity, substation capacity and bus voltage. The optimization variables considerably reduce the dimension of variables and speed up the process of optimizing. The effectiveness of the proposed approach was tested by a distribution system planning.
基金partially supported by the National Natural Science Foundation of China under Grant No.71871106the Fundamental Research Funds for the Central Universities under Grant Nos. JUSRP1809ZD,2019JDZD06, JUSRP321016+5 种基金sponsored by the Major Projects of Educational Science Fund of Jiangsu Province in 13th Five-Year Plan under Grant No. A/2016/01the Key Project of Philosophy and Social Science Research in Universities of Jiangsu Province under Grant No. 2018SJZDI051the Major Projects of Philosophy and Social Science Research of Guizhou Province under Grant No. 21GZZB32Project of Chinese Academic Degrees and Graduate Education under Grant No. 2020ZDB2Major research project of the 14th Five-Year Plan for Higher Education Scientific Research of Jiangsu Higher Education Association under Grant No. ZDGG02the Henan University of Technology High-level Talents Scientific Research Fund (2022BS043)
文摘This paper is to provide a novel approach for the spatial aggregation of judgment matrices.The optimal aggregation method of judgment matrices based on spatial Steiner-Weber point can effectively aggregate the preference information of group members and achieve the optimization of group preference.The method comprises three key elements:The spatial mapping of the judgment matrices,the spatial optimal aggregation model of the judgment matrices,and the plant growth simulation algorithm(PGSA)is used to find the optimal aggregation points.Firstly,the judgment matrices are mapped into a set of spatial multidimensional coordinates by using spatial mapping rules.Secondly,the spatial Steiner-Weber point is used as the prototype to construct the spatial aggregation model.Thirdly,the PGSA algorithm is used to find the spatial aggregation points,whose spatial weighted Euclidean distance to all the decision makers’preference points is minimal.The optimal aggregation matrix is composed of these optimal aggregation points,which can accurately reflect the decision maker's comprehensive opinions.Finally,the effectiveness and rationality of this method are verified by comparing with the classical group preference aggregation methods.
文摘P-Coumaric acid was previously reported to contain antioxidant,antidiabetic,anti-inflammatory,antiplatelet,antiulcer and anticancer activities.Along with these,the present work has been conducted to study the antibacterial activity of p-coumaric acid.It could be used to control broad-spectrum microbiome-based inflammation or in cancer control.HPLC analysis of methanolic extract from the mushroom Termitomyces heimii has exhibited a rich fraction of p-coumaric acid(p-CA),which in the pure form showed significant bactericidal potentials.To predict the molecular interactions associated with the bactericidal mechanism of p-CA,the transmembrane protein sequences of Staphylococcus aureus and Escherichia coli were retrieved from the IMG–JGI database,screened and then aligned using Clustal X2 and PHYLIP 3.69 softwares.The common sequences were subjected to tertiary structure prediction using Phyre2 server,followed by quality assessment through the Ramachandran plot.Next,the 3D molecular structure of p-CA was downloaded from PubChem and docked with the selected tertiary structures using Patchdock and showed higher affinity towards 12 common transmembrane protein structures,amongst which CDP-diacylglycerol–glycerol-3-phosphate 3-phosphatidyl transferase(PgsA)exhibited best dock-ing with p-CA on the basis of ACE value(–249 kcal/mol).This fact revealed that p-CA can block the normal functioning of membrane-bound enzyme PgsA,consequently leading to the interruption in the synthesis and recycling of an essential membrane component phosphatidylglycerol(PG),resulting in membrane disruption followed by cell lysis.Here,for the first time we reported the molecular insights and fundamental biochemical events underlying the bactericidal action by p-CA,to explore new perspective to combat multidrug-resistant bacteria.
