AIM： To explore the molecular mechanisms in lens development and the pathogenesis of Peters anomaly in Smad4 defective mice. METHODS： Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ect...AIM： To explore the molecular mechanisms in lens development and the pathogenesis of Peters anomaly in Smad4 defective mice. METHODS： Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ectoderm selectively. Pathological techniques were used to reveal the morphological changes of the anterior segment in Smad4 defective eye. Immunohistochemical staining was employed to observe the expression of E-cadherin, N- cadherin and α-SMA in anterior segment of Smad4 defective mice and control mice at embryonic （E） day 16.5. Real-time quantitative polymerase chain reaction （qPCR） was performed to detect the expression of Snail, Zebl, Zeb2 and Twist2 in lens of Smad4 defective mice and control mice at E16.5. RESULTS： Conditional deletion of Smad4 on eye surface ectoderm resulted in corneal dysplasia, iridocorneal angle closure, corneolenticular adhesions and cataract resembling Peters anomaly. Loss of Smad4 function inhibited E-cadherin expression in the lens epithelium cells and corneal epithelium cells in Smad4 defective eye. Expression of N-cadherin was upregulated in corneal epithelium and corneal stroma. Both E-cadherin and N-cadherin were down-regulated at the future trabecular meshwork region in mutant eye. The qPCR results showed that the expression of Twist2 was increased significantly in the mutant lens （P〈0.01）. CONCLUSION： Smad4 is essential to eye development and likely a candidate pathogenic gene to Peters anomaly by regulating epithelial-mesenchymal transition. Twist2 can be regulated by Smad4 and plays an essential role in lens development.展开更多
In this article, the 2-variable general polynomials are taken as base with Peters polynomials to introduce a family of 2-variable Peters mixed type polynomials.These polynomials are framed within the context of monomi...In this article, the 2-variable general polynomials are taken as base with Peters polynomials to introduce a family of 2-variable Peters mixed type polynomials.These polynomials are framed within the context of monomiality principle and their properties are established. Certain summation formulae for these polynomials are also derived. Examples of some members belonging to this family are considered and numbers related to some mixed special polynomials are also explored.展开更多
In recent years, the fluorescence photobleaching recovery (FPR) technique has been used for conducting a series of studies on the lateral mobility of proteins and lipids of the cell membrane. This technique was first ...In recent years, the fluorescence photobleaching recovery (FPR) technique has been used for conducting a series of studies on the lateral mobility of proteins and lipids of the cell membrane. This technique was first introduced by Peters et al. and later improved and developed by Koppel et al. Now it has become the principal method for a quantitative measurement of the lateral mobility of membrane components such as proteins. Hence increasing importance has been attached to it.展开更多
2015年1月,美国智库新美国安全中心(CNAS)发布一份报告——《介于钢铁侠与潜水侠之间——机械外衣海上应用的发展机遇》,作者为Andrew Herr(Mind Plus Matter和Helicase咨询公司首席执行官)和海军上校Scott Cheney-Peters(国际海上安全...2015年1月,美国智库新美国安全中心(CNAS)发布一份报告——《介于钢铁侠与潜水侠之间——机械外衣海上应用的发展机遇》,作者为Andrew Herr(Mind Plus Matter和Helicase咨询公司首席执行官)和海军上校Scott Cheney-Peters(国际海上安全中心论坛主席)。报告全文共21页,阐述了机械外衣的研发背景,所需支撑性技术的发展现状,指出了其在毁伤控制。展开更多
Background:Type 2 Peters anomaly is a rare anterior segment disorder characterized by central corneal leukoma with keratolenticular adhesion and cataract.Performing cataract surgery without corneal tissue transplantat...Background:Type 2 Peters anomaly is a rare anterior segment disorder characterized by central corneal leukoma with keratolenticular adhesion and cataract.Performing cataract surgery without corneal tissue transplantation in patients of type 2 Peters anomaly is extremely rare and challenging.We present a case of type 2 Peters anomaly treated by peeling off the adhesion without penetrating keratoplasty(PKP),in which restoration of corneal transparency is observed.Case presentation:An 11-month-old female infant of type 2 Peters anomaly presented with bilateral corneal opacity with distinct demarcation,keratolenticular adhesion and cataract,which was first noted at the age of 3 months.By peeling off the adhesion from corneal endothelium combined with lensectomy and vitrectomy,there was a gradual reduction in corneal opacity and improvement in visual acuity after surgery over a 2-year period.Her visual acuity had improved from light perception preoperatively to 20/50 at the latest follow-up.No sight-threatening postoperative complications were noted.Conclusion:It is safe and effective to peel off the keratolenticular adhesion in patients of type 2 Peters anomaly presented with distinctly demarcated corneal opacity.展开更多
在中国,几乎没有人知道Martie Peters这个英国壮年流氓,因为他组建的Push乐队在中国着实有点名不见经传的味道.然而曾发行过多张金属专辑的Push在欧洲大陆可谓是小有名气,他们曾和英国著名重金属乐队RONNIE JAMES DIO、丹麦前卫金... 在中国,几乎没有人知道Martie Peters这个英国壮年流氓,因为他组建的Push乐队在中国着实有点名不见经传的味道.然而曾发行过多张金属专辑的Push在欧洲大陆可谓是小有名气,他们曾和英国著名重金属乐队RONNIE JAMES DIO、丹麦前卫金属乐队ROYAL HUNT等一起巡演欧洲,并引起巨大的轰动.……展开更多
Y2002-63087-102 0213619合成孔径雷达成象数据压缩性能影响评价=Assessingthe performance effects of data compression for SAR im-agery[会,英]/Eckstein,B.A.& Peters,R.//Pro-ceedings of the Applied Imagery Pattern Recogn...Y2002-63087-102 0213619合成孔径雷达成象数据压缩性能影响评价=Assessingthe performance effects of data compression for SAR im-agery[会,英]/Eckstein,B.A.& Peters,R.//Pro-ceedings of the Applied Imagery Pattern RecognitionWorkshop.—102～108(PE)展开更多
Jeff Peters and Andy Tucker could never be trusted.One day,the two men decided to open a marriage business to make some quick and easy money.The first thingthey did was to fix up an advertisement to be published in ne...Jeff Peters and Andy Tucker could never be trusted.One day,the two men decided to open a marriage business to make some quick and easy money.The first thingthey did was to fix up an advertisement to be published in newspapers.Their advertisement read like this：展开更多
基金Supported by the National Natural Science Foundation of China(No.81470617No.81371003)Colleges and Universities Scientific Research Project of Liaoning Province,China(No.L2014305)
文摘AIM： To explore the molecular mechanisms in lens development and the pathogenesis of Peters anomaly in Smad4 defective mice. METHODS： Le-Cre transgenic mouse line was employed to inactivate Smad4 in the surface ectoderm selectively. Pathological techniques were used to reveal the morphological changes of the anterior segment in Smad4 defective eye. Immunohistochemical staining was employed to observe the expression of E-cadherin, N- cadherin and α-SMA in anterior segment of Smad4 defective mice and control mice at embryonic （E） day 16.5. Real-time quantitative polymerase chain reaction （qPCR） was performed to detect the expression of Snail, Zebl, Zeb2 and Twist2 in lens of Smad4 defective mice and control mice at E16.5. RESULTS： Conditional deletion of Smad4 on eye surface ectoderm resulted in corneal dysplasia, iridocorneal angle closure, corneolenticular adhesions and cataract resembling Peters anomaly. Loss of Smad4 function inhibited E-cadherin expression in the lens epithelium cells and corneal epithelium cells in Smad4 defective eye. Expression of N-cadherin was upregulated in corneal epithelium and corneal stroma. Both E-cadherin and N-cadherin were down-regulated at the future trabecular meshwork region in mutant eye. The qPCR results showed that the expression of Twist2 was increased significantly in the mutant lens （P〈0.01）. CONCLUSION： Smad4 is essential to eye development and likely a candidate pathogenic gene to Peters anomaly by regulating epithelial-mesenchymal transition. Twist2 can be regulated by Smad4 and plays an essential role in lens development.
基金UGC-BSR Reaserch Start-Up-Grant (Office Memo No. 30-90/2015(BSR)) awarded to the author by the University Grants Commission (UGC), Government of India, New Delhi
文摘In this article, the 2-variable general polynomials are taken as base with Peters polynomials to introduce a family of 2-variable Peters mixed type polynomials.These polynomials are framed within the context of monomiality principle and their properties are established. Certain summation formulae for these polynomials are also derived. Examples of some members belonging to this family are considered and numbers related to some mixed special polynomials are also explored.
文摘In recent years, the fluorescence photobleaching recovery (FPR) technique has been used for conducting a series of studies on the lateral mobility of proteins and lipids of the cell membrane. This technique was first introduced by Peters et al. and later improved and developed by Koppel et al. Now it has become the principal method for a quantitative measurement of the lateral mobility of membrane components such as proteins. Hence increasing importance has been attached to it.
文摘2015年1月,美国智库新美国安全中心(CNAS)发布一份报告——《介于钢铁侠与潜水侠之间——机械外衣海上应用的发展机遇》,作者为Andrew Herr(Mind Plus Matter和Helicase咨询公司首席执行官)和海军上校Scott Cheney-Peters(国际海上安全中心论坛主席)。报告全文共21页,阐述了机械外衣的研发背景,所需支撑性技术的发展现状,指出了其在毁伤控制。
文摘Background:Type 2 Peters anomaly is a rare anterior segment disorder characterized by central corneal leukoma with keratolenticular adhesion and cataract.Performing cataract surgery without corneal tissue transplantation in patients of type 2 Peters anomaly is extremely rare and challenging.We present a case of type 2 Peters anomaly treated by peeling off the adhesion without penetrating keratoplasty(PKP),in which restoration of corneal transparency is observed.Case presentation:An 11-month-old female infant of type 2 Peters anomaly presented with bilateral corneal opacity with distinct demarcation,keratolenticular adhesion and cataract,which was first noted at the age of 3 months.By peeling off the adhesion from corneal endothelium combined with lensectomy and vitrectomy,there was a gradual reduction in corneal opacity and improvement in visual acuity after surgery over a 2-year period.Her visual acuity had improved from light perception preoperatively to 20/50 at the latest follow-up.No sight-threatening postoperative complications were noted.Conclusion:It is safe and effective to peel off the keratolenticular adhesion in patients of type 2 Peters anomaly presented with distinctly demarcated corneal opacity.
文摘Y2002-63087-102 0213619合成孔径雷达成象数据压缩性能影响评价=Assessingthe performance effects of data compression for SAR im-agery[会,英]/Eckstein,B.A.& Peters,R.//Pro-ceedings of the Applied Imagery Pattern RecognitionWorkshop.—102～108(PE)
文摘Jeff Peters and Andy Tucker could never be trusted.One day,the two men decided to open a marriage business to make some quick and easy money.The first thingthey did was to fix up an advertisement to be published in newspapers.Their advertisement read like this：
