目的总结新生儿经皮中心静脉置管(percutaneous inserted central catheter,PICC)致静脉营养液渗漏的临床特点。方法回顾性分析2015年1月至2019年12月北京大学第三医院新生儿重症监护病房诊断的16例PICC致静脉营养液渗漏新生儿的临床特...目的总结新生儿经皮中心静脉置管(percutaneous inserted central catheter,PICC)致静脉营养液渗漏的临床特点。方法回顾性分析2015年1月至2019年12月北京大学第三医院新生儿重症监护病房诊断的16例PICC致静脉营养液渗漏新生儿的临床特点。采用描述性统计分析。结果本院PICC致静脉营养液渗漏的发生率为1.6%(16/1012)。16例PICC致静脉营养液渗漏患儿中13例胸腔渗漏,1例心包渗漏,2例脑脊液渗漏。16例均为早产儿,胎龄为(30.5±0.5)周,出生体重为(1314.4±62.1)g。给予PICC的日龄为(4.3±0.6)d。从PICC置入到发生静脉营养液渗漏间隔时间为(7.3±2.0)d。13例胸腔渗漏患儿均表现为呼吸困难、呼吸暂停及皮肤发绀,1例心包渗漏患儿除有以上表现外还有心动过缓和血压下降,2例脑脊液渗漏患儿主要表现为嗜睡和惊厥。发生胸腔和心包渗漏的14例患儿PICC均从右贵要静脉置入,仅5例导管前端初始位置正确;4例初始置入过深,当天调整;发生静脉营养液渗漏时导管前端位置发生偏移10例。发生脑脊液渗漏的2例患儿PICC均从左大隐静脉置入,导管前端初始位置均不正确,但均未调整,发生静脉营养液渗漏时2例均发生置管前端偏移。16例患儿经穿刺抽液及拔除PICC后临床症状迅速缓解,未再反复。结论PICC致静脉营养液渗漏可能与PICC置管前端向非中心静脉偏移有关。一旦诊断PICC致静脉营养液渗漏,应及时穿刺引流并拔除PICC,预后良好。展开更多
AIM:To investigate the use of lipid emulsion substitutingfor glucose in postoperative hypocaloric peripheral parenteral nutrition (HPPN).METHODS:This prospective, randomized study was conducted on 20 postoperative gas...AIM:To investigate the use of lipid emulsion substitutingfor glucose in postoperative hypocaloric peripheral parenteral nutrition (HPPN).METHODS:This prospective, randomized study was conducted on 20 postoperative gastrointestinal cancer patients. They were randomized and equally divided into interventional group and control group, and both were administered isocaloric and isonitrogenous diets with for lipid emulsion substituting for partial glucose loads in the interventional group.RESULTS: Nutritional parameters and biochemical data were compared between the two groups before and after 6-d of HPPN. Most investigated variables showed no significant changes after administration of HPPN with lipid emulsion. However, the postoperative triglyceride level was significantly lower in the interventional group than in the control group (P < 0.05). In comparison with lipid emulsion, glucose administration resulted in less decrease in postoperative prealbumin level (P < 0.05).CONCLUSION: In addition to supplementing with essential fatty acid, it seems that HPPN with lipid emulsion is well-tolerated and beneficial to postoperative gastrointestinal cancer patients.展开更多
文摘目的总结新生儿经皮中心静脉置管(percutaneous inserted central catheter,PICC)致静脉营养液渗漏的临床特点。方法回顾性分析2015年1月至2019年12月北京大学第三医院新生儿重症监护病房诊断的16例PICC致静脉营养液渗漏新生儿的临床特点。采用描述性统计分析。结果本院PICC致静脉营养液渗漏的发生率为1.6%(16/1012)。16例PICC致静脉营养液渗漏患儿中13例胸腔渗漏,1例心包渗漏,2例脑脊液渗漏。16例均为早产儿,胎龄为(30.5±0.5)周,出生体重为(1314.4±62.1)g。给予PICC的日龄为(4.3±0.6)d。从PICC置入到发生静脉营养液渗漏间隔时间为(7.3±2.0)d。13例胸腔渗漏患儿均表现为呼吸困难、呼吸暂停及皮肤发绀,1例心包渗漏患儿除有以上表现外还有心动过缓和血压下降,2例脑脊液渗漏患儿主要表现为嗜睡和惊厥。发生胸腔和心包渗漏的14例患儿PICC均从右贵要静脉置入,仅5例导管前端初始位置正确;4例初始置入过深,当天调整;发生静脉营养液渗漏时导管前端位置发生偏移10例。发生脑脊液渗漏的2例患儿PICC均从左大隐静脉置入,导管前端初始位置均不正确,但均未调整,发生静脉营养液渗漏时2例均发生置管前端偏移。16例患儿经穿刺抽液及拔除PICC后临床症状迅速缓解,未再反复。结论PICC致静脉营养液渗漏可能与PICC置管前端向非中心静脉偏移有关。一旦诊断PICC致静脉营养液渗漏,应及时穿刺引流并拔除PICC,预后良好。
文摘AIM:To investigate the use of lipid emulsion substitutingfor glucose in postoperative hypocaloric peripheral parenteral nutrition (HPPN).METHODS:This prospective, randomized study was conducted on 20 postoperative gastrointestinal cancer patients. They were randomized and equally divided into interventional group and control group, and both were administered isocaloric and isonitrogenous diets with for lipid emulsion substituting for partial glucose loads in the interventional group.RESULTS: Nutritional parameters and biochemical data were compared between the two groups before and after 6-d of HPPN. Most investigated variables showed no significant changes after administration of HPPN with lipid emulsion. However, the postoperative triglyceride level was significantly lower in the interventional group than in the control group (P < 0.05). In comparison with lipid emulsion, glucose administration resulted in less decrease in postoperative prealbumin level (P < 0.05).CONCLUSION: In addition to supplementing with essential fatty acid, it seems that HPPN with lipid emulsion is well-tolerated and beneficial to postoperative gastrointestinal cancer patients.
