Type A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill patients. However, current therapeutic agents are still in shortage and can even be ha...Type A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill patients. However, current therapeutic agents are still in shortage and can even be harmful. This paper reviewed data regarding lactic acidosis treatment and recommended that pyruvate might be a potential alkalizer to correct type A lactic acidosis in future clinical practice. Pyruvate is a key energy metabolic substrate and a pyruvate dehydrogenase(PDH) activator with several unique beneficial biological properties, including anti-oxidant and antiinflammatory effects and the ability to activate the hypoxia-inducible factor-1(HIF-1α)-erythropoietin(EPO) signal pathway. Pyruvate preserves glucose metabolism and cellular energetics better than bicarbonate, lactate, acetate and malate in the efficient correction of hypoxic lactic acidosis and shows few side effects. Therefore, application of pyruvate may be promising and safe as a novel therapeutic strategy in hypoxic lactic acidosis correction accompanied with multi-organ protection in critical care patients.展开更多
SDH作为当今通信网络重要的传输手段,具有前向和后向兼容性,各种不同速率的PDH信号、B-ISDN和ATM信号及其他新业务信号可通过适配复用进STM-N帧。论文通过对SDH复用原理的研究,提出了一种取代成帧器,基于FPGA的从STM-4提取VC-12解复用...SDH作为当今通信网络重要的传输手段,具有前向和后向兼容性,各种不同速率的PDH信号、B-ISDN和ATM信号及其他新业务信号可通过适配复用进STM-N帧。论文通过对SDH复用原理的研究,提出了一种取代成帧器,基于FPGA的从STM-4提取VC-12解复用的设计方法,并选用Altera公司Stratix ii gx系列FPGA进行方案实现,最后加载到FPGA,在SDH测试仪搭建的环境下,利用QUARTUS II的在线采集工具SignalTap对设计进行了验证。展开更多
基金supported by the National Natural Science Foundation of China(No.81700181,No.81600148)
文摘Type A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill patients. However, current therapeutic agents are still in shortage and can even be harmful. This paper reviewed data regarding lactic acidosis treatment and recommended that pyruvate might be a potential alkalizer to correct type A lactic acidosis in future clinical practice. Pyruvate is a key energy metabolic substrate and a pyruvate dehydrogenase(PDH) activator with several unique beneficial biological properties, including anti-oxidant and antiinflammatory effects and the ability to activate the hypoxia-inducible factor-1(HIF-1α)-erythropoietin(EPO) signal pathway. Pyruvate preserves glucose metabolism and cellular energetics better than bicarbonate, lactate, acetate and malate in the efficient correction of hypoxic lactic acidosis and shows few side effects. Therefore, application of pyruvate may be promising and safe as a novel therapeutic strategy in hypoxic lactic acidosis correction accompanied with multi-organ protection in critical care patients.
文摘SDH作为当今通信网络重要的传输手段,具有前向和后向兼容性,各种不同速率的PDH信号、B-ISDN和ATM信号及其他新业务信号可通过适配复用进STM-N帧。论文通过对SDH复用原理的研究,提出了一种取代成帧器,基于FPGA的从STM-4提取VC-12解复用的设计方法,并选用Altera公司Stratix ii gx系列FPGA进行方案实现,最后加载到FPGA,在SDH测试仪搭建的环境下,利用QUARTUS II的在线采集工具SignalTap对设计进行了验证。
