Photodynamic therapy plays an important role in cancer treatment.In this work,methylene blue(MB)-embedded calcium carbonate nanorods(CaCO_3-MB NRs)have been synthesized for p H-responsive photodynamic therapy and ultr...Photodynamic therapy plays an important role in cancer treatment.In this work,methylene blue(MB)-embedded calcium carbonate nanorods(CaCO_3-MB NRs)have been synthesized for p H-responsive photodynamic therapy and ultrasound imaging.The morphology of CaCO_3-MB NRs can be controlled by modulating the concentration of Na_2CO_3 aqueous solution.The generation of effective reactive oxygen species(ROS)were confirmed by 1,3-diphenylisobenzofuran(DPBF)probe.Both photodynamic therapy performance and echogenic performance of CaCO_3-MB NRs were investigated to confirm the feasibility of CaCO_3-MB nanohybrids for ultrasound image-guided photodynamic therapy.展开更多
In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles （MSNs） with a func...In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles （MSNs） with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanopartides, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail.展开更多
Developing methods for efficient product/catalyst separation and catalyst recycling is meaningful in multi-phase catalytic reactions. Here, we reported a p H-responsive emulsion system stabilized by interfacially acti...Developing methods for efficient product/catalyst separation and catalyst recycling is meaningful in multi-phase catalytic reactions. Here, we reported a p H-responsive emulsion system stabilized by interfacially active TiO2 nanoparticles for achieving in situ product/catalyst separation and catalyst recycling. In this system, emulsification and demulsification process could be easily engineered through tuning the p H values. The emulsion droplets were destroyed completely at a p H value of 3–4, and the solid catalyst distributed in the aqueous phase could be used to the next reaction cycle after removal of the organic product and adjusting the p H to 7–8. Such a p H triggered switchable Pickering emulsion catalytic system not only shows good recyclability of the solid catalyst but also high catalytic efficiency,and could be recycled more than 10 cycles.展开更多
Multimodal combinatorial therapy merges different modes of therapies in one platform,which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatm...Multimodal combinatorial therapy merges different modes of therapies in one platform,which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatment efficiency.Here we report a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive chemotherapy.By super-assembly of mesoporous silica nanoparticles(MSN)with metal-phenolic networks(MPN),anti-cancer drugs can be loaded in the MSN matrix,while the outer MPN coating allows dual photothermal and pH-responsive properties.Upon near-infrared light irradiation,the MSN@MPN nanoplatform exhibits excellent photothermal effect,and demonstrates outstanding pH-triggered drug release property.In vitro cell experiments suggest the MSN@MPN system exhibits superior biocompatibility and can effectively kill tumor cells after loading anti-cancer drugs.Consequently,the MSN@MPN system shows promising prospects in clinical application for tumor therapy.展开更多
基金supported by the National Key Research and Development Program of China (2017YFA0106100, 2016YFA0201501)National Natural Science Foundation of China (51325304, 51373017, 51473014, 51521062, 51773013)+1 种基金the Fundamental Research Funds for the Central Universities (BHYC1705A)Higher Education and High-quality and World-class Universities (PY201603)
文摘Photodynamic therapy plays an important role in cancer treatment.In this work,methylene blue(MB)-embedded calcium carbonate nanorods(CaCO_3-MB NRs)have been synthesized for p H-responsive photodynamic therapy and ultrasound imaging.The morphology of CaCO_3-MB NRs can be controlled by modulating the concentration of Na_2CO_3 aqueous solution.The generation of effective reactive oxygen species(ROS)were confirmed by 1,3-diphenylisobenzofuran(DPBF)probe.Both photodynamic therapy performance and echogenic performance of CaCO_3-MB NRs were investigated to confirm the feasibility of CaCO_3-MB nanohybrids for ultrasound image-guided photodynamic therapy.
基金supported by the Chinese Natural Science Foundation Project (Grant No. 30970784 and 81171455)a National Distinguished Young Scholars Grant (Grant No. 31225009) from the National Natural Science Foundation of China+5 种基金the National Key Basic Research Program of China (Grant No. 2009CB930200)the Chinese Academy of Sciences (CAS) ‘Hundred Talents Program’ (Grant No. 07165111ZX)the CAS Knowledge Innovation Program, and the State HighTech Development Plan (Grant No. 2012AA020804)the ‘Strategic Priority Research Program’ of the Chinese Academy of Sciences (Grant No. XDA09030301)NIH/NIMHD 8 G12 MD007597USAMRMC W81XWH-10-1-0767 grants
文摘In the fight against cancer, controlled drug delivery systems have emerged to enhance the therapeutic efficacy and safety of anti-cancer drugs. Among these systems, mesoporous silica nanoparticles （MSNs） with a functional surface possess obvious advantages and were thus rapidly developed for cancer treatment. Many stimuli-responsive materials, such as nanopartides, polymers, and inorganic materials, have been applied as caps and gatekeepers to control drug release from MSNs. This review presents an overview of the recent progress in the production of pH-responsive MSNs based on the pH gradient between normal tissues and the tumor microenvironment. Four main categories of gatekeepers can respond to acidic conditions. These categories will be described in detail.
基金the Natural Science Foundation of China (Nos. 21733009, 21573136, and U1510105)the Key Scientist and Technology Program of Shanxi Province (No. 20150313003-1)Shanxi Scholarship Council of China (No. 2015-003)
文摘Developing methods for efficient product/catalyst separation and catalyst recycling is meaningful in multi-phase catalytic reactions. Here, we reported a p H-responsive emulsion system stabilized by interfacially active TiO2 nanoparticles for achieving in situ product/catalyst separation and catalyst recycling. In this system, emulsification and demulsification process could be easily engineered through tuning the p H values. The emulsion droplets were destroyed completely at a p H value of 3–4, and the solid catalyst distributed in the aqueous phase could be used to the next reaction cycle after removal of the organic product and adjusting the p H to 7–8. Such a p H triggered switchable Pickering emulsion catalytic system not only shows good recyclability of the solid catalyst but also high catalytic efficiency,and could be recycled more than 10 cycles.
基金This work was supported by the National Key Research and Development Program of China(Nos.2019YFC1604600,2017YFA0206901,2017YFA0206900)the National Natural Science Foundation of China(Nos.21705027,21974029,81830052),the Construction project of Shanghai Key Laboratory of Molecular Imaging(No.18DZ2260400)+3 种基金the Shanghai Municipal Education Commission(Class II Plateau Disciplinary C onstruction Program of Medical Technology of SUMHS,2018-2020)the Australia National Health and Medical Research Council(NHMRC)(No.APP1163786)the Scientia Fellowship program at UNSW,the MCTL Visiting Fellowship Program,Shanghai Key Laboratory of Molecular Imaging(No.18DZ2260400)the Natural Science Foundation of Shanghai,and the Recruitm ent Program of Global Experts of China and Shanghai.
文摘Multimodal combinatorial therapy merges different modes of therapies in one platform,which can overcome several clinical challenges such as premature drug loss during blood circulation and significantly improve treatment efficiency.Here we report a combinatorial therapy nanoplatform that enables dual photothermal therapy and pH-stimulus-responsive chemotherapy.By super-assembly of mesoporous silica nanoparticles(MSN)with metal-phenolic networks(MPN),anti-cancer drugs can be loaded in the MSN matrix,while the outer MPN coating allows dual photothermal and pH-responsive properties.Upon near-infrared light irradiation,the MSN@MPN nanoplatform exhibits excellent photothermal effect,and demonstrates outstanding pH-triggered drug release property.In vitro cell experiments suggest the MSN@MPN system exhibits superior biocompatibility and can effectively kill tumor cells after loading anti-cancer drugs.Consequently,the MSN@MPN system shows promising prospects in clinical application for tumor therapy.
