不引入有机溶剂,低温下将对甲苯磺酰氯与β-环糊精在NaOH水溶液中进行非均相反应,得到了单6-氧-对甲苯磺酰-β-环糊精酯(6-OTs-β-CD)。借助1 H NMR谱证实了环糊精单磺酰化机理。考察了产物的水解因素,研究了反应条件对产率的影响。实...不引入有机溶剂,低温下将对甲苯磺酰氯与β-环糊精在NaOH水溶液中进行非均相反应,得到了单6-氧-对甲苯磺酰-β-环糊精酯(6-OTs-β-CD)。借助1 H NMR谱证实了环糊精单磺酰化机理。考察了产物的水解因素,研究了反应条件对产率的影响。实验结果表明,投料摩尔比n(CD):n(TsCl)=4:1,碱液浓度0.75 mol/L,反应物质量分数4.7%,反应温度0℃,反应5 h时,6位单酯化收率为43.4%。展开更多
The catalytic application of p-toluenesulfonyl chloride for efficient acetylation of various types of alcohols and phenols with acetic anhydride in solvent-free conditions is reported.Also structurally diverse alcohol...The catalytic application of p-toluenesulfonyl chloride for efficient acetylation of various types of alcohols and phenols with acetic anhydride in solvent-free conditions is reported.Also structurally diverse alcohols were formylated using formic acid based on the use of catalytic amount of p-toluenesulfonyl chloride under solvent-free condition.The reactions were carried out in short reaction time and in good to excellent yields at room temperature.展开更多
文摘不引入有机溶剂,低温下将对甲苯磺酰氯与β-环糊精在NaOH水溶液中进行非均相反应,得到了单6-氧-对甲苯磺酰-β-环糊精酯(6-OTs-β-CD)。借助1 H NMR谱证实了环糊精单磺酰化机理。考察了产物的水解因素,研究了反应条件对产率的影响。实验结果表明,投料摩尔比n(CD):n(TsCl)=4:1,碱液浓度0.75 mol/L,反应物质量分数4.7%,反应温度0℃,反应5 h时,6位单酯化收率为43.4%。
文摘The catalytic application of p-toluenesulfonyl chloride for efficient acetylation of various types of alcohols and phenols with acetic anhydride in solvent-free conditions is reported.Also structurally diverse alcohols were formylated using formic acid based on the use of catalytic amount of p-toluenesulfonyl chloride under solvent-free condition.The reactions were carried out in short reaction time and in good to excellent yields at room temperature.
