Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and healing proc...Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and healing process in older horses. Metabolic pathway analysis showed an obvious dysregulation of several signaling pathways related to cartilage formation and cartilage repair such as Wnt/β-catenin, Indian hedgehog and TGF-β signaling pathways. Other regulated genes appeared to be involved in high carbohydrate diet, abnormal insulin metabolism or inflammation. Sclerostin is an osteocyte-secreted soluble antagonist of the Wnt/β-catenin signaling pathway. It is crucial for osteoblast development and activity and is increased in naturally occurring lesions of equine osteochondrosis. The aim of this study is to compare the circulating sclerostin levels between OC-affected (n = 20) and healthy horses (n = 19). A significant linear regression between plasma sclerostin and age is observed especially in the healthy young horses. The mean plasma sclerostin concentration is significantly higher in young horses suffering from osteochondrosis compared to the control horses. These results reinforce the possible role of the Wnt/β-catenin signaling pathway in the OC pathogeny. The inhibition of this essential pathway could disturb the osteo-chondral differentiation. More studies are currently needed to define the eventual clinic interest of plasma sclerostin as future biomarker in bone and cartilage diseases.展开更多
Background： Osteochondrosis of spine is the one of the most prevalent diseases among the all musculoskeletal conditions. Osteochondrosis is not a curable condition and its treatment/rehabilitation is a long-term proc...Background： Osteochondrosis of spine is the one of the most prevalent diseases among the all musculoskeletal conditions. Osteochondrosis is not a curable condition and its treatment/rehabilitation is a long-term process. The present work aims to assess clinical effectiveness and duration of outcomes of rehabilitation that includes complex and consequent methods （algorithm） of treatment. The pilot study has been continuing several years and now is going on. Methods： The subject were 220 patients, 122 females and 98 males, aged 50-65 （adherence to treatment 100%） with as reflex as well radicular syndromes in subacute phase. Informed consent was obtained from all patients. Rehabilitation process continued 2.5-3 months and its management included the following consequent methods： waist fixation, pain control with medication （NSAIDs and in some cases steroidal drugs）, iontophoresis with karipazim-20-25 sessions, after 8-10 sessions of the latter manual therapy was added-10-12 sessions, and kinesiotherapy （3 times per week） after 5 procedures. After pain management recommendation of daily life activity was given. Oral chondroprotectors after completion of a treatment were administered. Dynamic evaluation of subjective and objective symptoms, mobility and functional state of spine were done. Parameters were assessed before treatment, after 3 month and 1-3 years upon its completion. Results： Data were analyzed using SPSS program. Obtained results showed that after the first course of treatment （3 months） positive outcomes were observed in 198 patients （90%）, 22 （10%） of patients required the second course of rehabilitation. Stable outcome of treatment was maintained after 1 year in 204 patients （92.7%） and after 3 years in 196 patients （89%）. Conclusion： Approbated complex of treatment is established to be effective in rehabilitation of patients with lumbar osteochondrosis.展开更多
文摘Osteochondrosis (OC) is a developmental disease in horses with a significant impact on the horse’s welfare and performance. The early disturbance of enchondral ossification progresses to inflammatory and healing process in older horses. Metabolic pathway analysis showed an obvious dysregulation of several signaling pathways related to cartilage formation and cartilage repair such as Wnt/β-catenin, Indian hedgehog and TGF-β signaling pathways. Other regulated genes appeared to be involved in high carbohydrate diet, abnormal insulin metabolism or inflammation. Sclerostin is an osteocyte-secreted soluble antagonist of the Wnt/β-catenin signaling pathway. It is crucial for osteoblast development and activity and is increased in naturally occurring lesions of equine osteochondrosis. The aim of this study is to compare the circulating sclerostin levels between OC-affected (n = 20) and healthy horses (n = 19). A significant linear regression between plasma sclerostin and age is observed especially in the healthy young horses. The mean plasma sclerostin concentration is significantly higher in young horses suffering from osteochondrosis compared to the control horses. These results reinforce the possible role of the Wnt/β-catenin signaling pathway in the OC pathogeny. The inhibition of this essential pathway could disturb the osteo-chondral differentiation. More studies are currently needed to define the eventual clinic interest of plasma sclerostin as future biomarker in bone and cartilage diseases.
文摘Background： Osteochondrosis of spine is the one of the most prevalent diseases among the all musculoskeletal conditions. Osteochondrosis is not a curable condition and its treatment/rehabilitation is a long-term process. The present work aims to assess clinical effectiveness and duration of outcomes of rehabilitation that includes complex and consequent methods （algorithm） of treatment. The pilot study has been continuing several years and now is going on. Methods： The subject were 220 patients, 122 females and 98 males, aged 50-65 （adherence to treatment 100%） with as reflex as well radicular syndromes in subacute phase. Informed consent was obtained from all patients. Rehabilitation process continued 2.5-3 months and its management included the following consequent methods： waist fixation, pain control with medication （NSAIDs and in some cases steroidal drugs）, iontophoresis with karipazim-20-25 sessions, after 8-10 sessions of the latter manual therapy was added-10-12 sessions, and kinesiotherapy （3 times per week） after 5 procedures. After pain management recommendation of daily life activity was given. Oral chondroprotectors after completion of a treatment were administered. Dynamic evaluation of subjective and objective symptoms, mobility and functional state of spine were done. Parameters were assessed before treatment, after 3 month and 1-3 years upon its completion. Results： Data were analyzed using SPSS program. Obtained results showed that after the first course of treatment （3 months） positive outcomes were observed in 198 patients （90%）, 22 （10%） of patients required the second course of rehabilitation. Stable outcome of treatment was maintained after 1 year in 204 patients （92.7%） and after 3 years in 196 patients （89%）. Conclusion： Approbated complex of treatment is established to be effective in rehabilitation of patients with lumbar osteochondrosis.
