背景与目的血清癌胚抗原(carcinoembryonic antigen,CEA)和细胞角蛋白19的可溶性片段(soluble fragment of cytokeratin-19,CYFRA21-1)系非小细胞肺癌(non-small cell lung cancer,NSCLC)患者术前检查重要的肿瘤标志物(tumor markers,TM...背景与目的血清癌胚抗原(carcinoembryonic antigen,CEA)和细胞角蛋白19的可溶性片段(soluble fragment of cytokeratin-19,CYFRA21-1)系非小细胞肺癌(non-small cell lung cancer,NSCLC)患者术前检查重要的肿瘤标志物(tumor markers,TMs),但其对NSCLC患者术后的预后作用尚存争议。本研究旨在探讨血清CEA和CYFRA21-1在手术治疗后的NSCLC患者预后中的临床价值。方法回顾性总结175例经手术并辅以化疗的NSCLC患者的临床资料及随访情况,依据CEA、CYFRA21-1水平进行分组,用Kaplan-Meier法对各组进行生存分析。用Cox比例风险回归模型分析影响NSCLC患者术后预后的因素。结果术前CEA、CYFRA21-1升高组的患者总生存时间(overall survival,OS)少于术前正常组的患者,术前CYFRA21-1升高组差异有统计学意义(P=0.001)。与术前术后CEA、CYFRA21-1均正常等组的患者OS比较,术前术后CEA、CYFRA21-1均升高组的患者OS最短,两组差异均有统计学意义(P<0.05)。与CEA联合CYFRA21-1术前术后均正常等组的患者OS比较,CEA联合CYFRA21-1术前术后均升高组的患者OS最短,差异有统计学意义(P<0.001)。CEACYFRA21-1(HHHH)、CEACYFRA21-1(NNHH)、CYFRA21-1(HH)、CEA(HH)、男性是判断预后的独立危险因素(P<0.05)。结论血清CEA或CYFRA21-1在手术前及术后均高于正常,尤其是两者联合在手术前及术后均升高的NSCLC患者预后不良。手术前后血清CEA、CYFRA21-1的检测有助于NSCLC患者术后预后的判断。展开更多
Located in the East Qinling molybdenum metallogenic belt on the southern margin of the North China craton, the Nannihu Mo (-W) orefield comprising Nannihu, Sandaozhuang, and Shangfanggou deposits is a superlarge skarn...Located in the East Qinling molybdenum metallogenic belt on the southern margin of the North China craton, the Nannihu Mo (-W) orefield comprising Nannihu, Sandaozhuang, and Shangfanggou deposits is a superlarge skarn-porphyry Mo (-W) orefield in the world. Re-Os dating was performed of six molybdenite samples from the Mo deposits in the Nannihu Mo orefield with inductively coupled plasma mass spectrometry (ICP-MS). The results show that the Re-Os model ages are 145.8±2.1-141.8±2.1 Ma for the Nannihu deposit, 145.4±2.0-144.5±2.2 Ma (averaging 145.0±2.2 Ma) for the Sandaozhuang deposit and 145.8±2.1-143.8±2.1 Ma (averaging 144.8±2.1 Ma) for the Shangfanggou deposit; dating of the six samples yields an isochron age of 141.5±7.8 Ma (2σ), which accurately determines the timing of mineralization. The results also suggest that the ore-forming materials were mainly derived from the lower crust, mixed with minor mantle components. These Mo deposits were formed during the transition of the Mesozoic tectonic regime in eastern China, and its mineralization was a part of the Late Mesozoic large-scale mineralization in that region.展开更多
The large-scale Huangshaping Pb-Zn-W-Mo polymetallic deposit is located in the central Nanling min- eralization zone, South China. Six molybdenite samples from the Huangshaping deposit were selected for Re-Os isotope ...The large-scale Huangshaping Pb-Zn-W-Mo polymetallic deposit is located in the central Nanling min- eralization zone, South China. Six molybdenite samples from the Huangshaping deposit were selected for Re-Os isotope measurement in order to define the mineralization age of the deposit. It yields a Re-Os isochron age of 154.8±1.9 Ma (2σ ), which is in accordance with the Re-Os model ages of 150.9― 156.9 Ma. This age is about 7 Ma younger than their host granite porphyry, which was dated as 161.6±1.1 Ma by zircon U-Pb method using LA-ICPMS. All these ages demonstrate that the Huang- shaping granite and related Pb-Zn-W-Mo deposit occurred in the middle Yanshanian period, when many other granitoid and related ore deposits emplaced and formed, e.g. the Qitianling granite and Furong tin deposit, the Qianlishan granite and giant Shizhuyuan W-Sn-Mo-Bi deposit and Jinchuantang Sn-Bi deposit in the nearby area. They constitute the main part of the magmatic-metallogenic belt of southern Hunan, and represent the large-scale metallogeny in middle Yanshanian in the area. The lower rhenium content in molybdenite of Huangshaping deposit suggests that the ore-forming material was mainly of crust origin.展开更多
The Erlihe Pb-Zn deposit is an important mine of the Pb-Zn metallogenic zone in the South Qinling Orogen.It has been considered a sedimentary exhalative deposit in previous investigations because the ore body occurs c...The Erlihe Pb-Zn deposit is an important mine of the Pb-Zn metallogenic zone in the South Qinling Orogen.It has been considered a sedimentary exhalative deposit in previous investigations because the ore body occurs concordantly at the transitional location of an upright fold.Re and Os isotopic analyses for paragenetic pyrites with sphalerite and galena from the ore body have been used to determine the timing of mineralization and to trace the source of metallogenic materials.The Re-Os isotopic data of four pyrite samples construct an isochron,yielding a weighted average age of 226±17 Ma（mean square weighted deviation=1.7）,which is considered the main mineralization age.A dioritic porphyrite vein sample,showing weaker mineralization,was also dated using the SHRIMP zircon UPb isotopic method to constrain the youngest metallogenic age of the ore deposit,because it distributes along a group of tensional joints cutting not only the upright fold in the deposit field,but also the main ore bodies.The dioritic porphyrite sample yields a weighted mean ^（206）Pb/^（238）U age of 221±3 Ma,which is slightly younger than the Re-Os isotopic isochron age of the pyrites,considered as the upper age limit of the mineralization,namely the ending age of the mineralization.The Os isotopic compositions of sulfide minerals distribute within a range between Os isotopic compositions of the crust and the mantle, indicating that the ore deposit can be derived from magma-related fluid,and the metallogenic materials are most likely derived from the mixing source of the crust and the mantle.The Erlihe Pb-Zn deposit and associated dioritic porphyrite vein,important records of Qinling tectonic-magmatism-mineralization activities,were formed during the Triassic collisional orogeny processes.展开更多
An isochron age of 282±20 (95% conf. limit) Ma of the sulfide ores in the Huangshandong Cu-Ni sulfide deposit, the East Tianshan Mountains has been obtained through Re-Os isotopic measurement. The age implies tha...An isochron age of 282±20 (95% conf. limit) Ma of the sulfide ores in the Huangshandong Cu-Ni sulfide deposit, the East Tianshan Mountains has been obtained through Re-Os isotopic measurement. The age implies that the Cu-Ni sulfide deposit and other related deposits in the same area occurred in a Permian extensional environment of post-collision instead of Devonian-Early Carboniferous ophiolite-related oceanic or island arc environments inferred before. It shares the same ages with the orogenic and epithermal gold deposit systems in the same area. An initial 187Os/188Os ratio of 0.25±0.04 (1σ) and a γos value of 99 on average display the participation of large quantities of crustal components into the rock-forming and ore-forming system during mineralization and magmatic emplacement.展开更多
文摘背景与目的血清癌胚抗原(carcinoembryonic antigen,CEA)和细胞角蛋白19的可溶性片段(soluble fragment of cytokeratin-19,CYFRA21-1)系非小细胞肺癌(non-small cell lung cancer,NSCLC)患者术前检查重要的肿瘤标志物(tumor markers,TMs),但其对NSCLC患者术后的预后作用尚存争议。本研究旨在探讨血清CEA和CYFRA21-1在手术治疗后的NSCLC患者预后中的临床价值。方法回顾性总结175例经手术并辅以化疗的NSCLC患者的临床资料及随访情况,依据CEA、CYFRA21-1水平进行分组,用Kaplan-Meier法对各组进行生存分析。用Cox比例风险回归模型分析影响NSCLC患者术后预后的因素。结果术前CEA、CYFRA21-1升高组的患者总生存时间(overall survival,OS)少于术前正常组的患者,术前CYFRA21-1升高组差异有统计学意义(P=0.001)。与术前术后CEA、CYFRA21-1均正常等组的患者OS比较,术前术后CEA、CYFRA21-1均升高组的患者OS最短,两组差异均有统计学意义(P<0.05)。与CEA联合CYFRA21-1术前术后均正常等组的患者OS比较,CEA联合CYFRA21-1术前术后均升高组的患者OS最短,差异有统计学意义(P<0.001)。CEACYFRA21-1(HHHH)、CEACYFRA21-1(NNHH)、CYFRA21-1(HH)、CEA(HH)、男性是判断预后的独立危险因素(P<0.05)。结论血清CEA或CYFRA21-1在手术前及术后均高于正常,尤其是两者联合在手术前及术后均升高的NSCLC患者预后不良。手术前后血清CEA、CYFRA21-1的检测有助于NSCLC患者术后预后的判断。
文摘Located in the East Qinling molybdenum metallogenic belt on the southern margin of the North China craton, the Nannihu Mo (-W) orefield comprising Nannihu, Sandaozhuang, and Shangfanggou deposits is a superlarge skarn-porphyry Mo (-W) orefield in the world. Re-Os dating was performed of six molybdenite samples from the Mo deposits in the Nannihu Mo orefield with inductively coupled plasma mass spectrometry (ICP-MS). The results show that the Re-Os model ages are 145.8±2.1-141.8±2.1 Ma for the Nannihu deposit, 145.4±2.0-144.5±2.2 Ma (averaging 145.0±2.2 Ma) for the Sandaozhuang deposit and 145.8±2.1-143.8±2.1 Ma (averaging 144.8±2.1 Ma) for the Shangfanggou deposit; dating of the six samples yields an isochron age of 141.5±7.8 Ma (2σ), which accurately determines the timing of mineralization. The results also suggest that the ore-forming materials were mainly derived from the lower crust, mixed with minor mantle components. These Mo deposits were formed during the transition of the Mesozoic tectonic regime in eastern China, and its mineralization was a part of the Late Mesozoic large-scale mineralization in that region.
基金Supported by the State Key Fundamental Research Project (Grant No. G1999CB403209) the National Natural Science Foundation of China (Grant No. 40572057)
文摘The large-scale Huangshaping Pb-Zn-W-Mo polymetallic deposit is located in the central Nanling min- eralization zone, South China. Six molybdenite samples from the Huangshaping deposit were selected for Re-Os isotope measurement in order to define the mineralization age of the deposit. It yields a Re-Os isochron age of 154.8±1.9 Ma (2σ ), which is in accordance with the Re-Os model ages of 150.9― 156.9 Ma. This age is about 7 Ma younger than their host granite porphyry, which was dated as 161.6±1.1 Ma by zircon U-Pb method using LA-ICPMS. All these ages demonstrate that the Huang- shaping granite and related Pb-Zn-W-Mo deposit occurred in the middle Yanshanian period, when many other granitoid and related ore deposits emplaced and formed, e.g. the Qitianling granite and Furong tin deposit, the Qianlishan granite and giant Shizhuyuan W-Sn-Mo-Bi deposit and Jinchuantang Sn-Bi deposit in the nearby area. They constitute the main part of the magmatic-metallogenic belt of southern Hunan, and represent the large-scale metallogeny in middle Yanshanian in the area. The lower rhenium content in molybdenite of Huangshaping deposit suggests that the ore-forming material was mainly of crust origin.
基金supported by the National Scientific and Technological Support Program of China (grant no:2006BAB01A11)
文摘The Erlihe Pb-Zn deposit is an important mine of the Pb-Zn metallogenic zone in the South Qinling Orogen.It has been considered a sedimentary exhalative deposit in previous investigations because the ore body occurs concordantly at the transitional location of an upright fold.Re and Os isotopic analyses for paragenetic pyrites with sphalerite and galena from the ore body have been used to determine the timing of mineralization and to trace the source of metallogenic materials.The Re-Os isotopic data of four pyrite samples construct an isochron,yielding a weighted average age of 226±17 Ma（mean square weighted deviation=1.7）,which is considered the main mineralization age.A dioritic porphyrite vein sample,showing weaker mineralization,was also dated using the SHRIMP zircon UPb isotopic method to constrain the youngest metallogenic age of the ore deposit,because it distributes along a group of tensional joints cutting not only the upright fold in the deposit field,but also the main ore bodies.The dioritic porphyrite sample yields a weighted mean ^（206）Pb/^（238）U age of 221±3 Ma,which is slightly younger than the Re-Os isotopic isochron age of the pyrites,considered as the upper age limit of the mineralization,namely the ending age of the mineralization.The Os isotopic compositions of sulfide minerals distribute within a range between Os isotopic compositions of the crust and the mantle, indicating that the ore deposit can be derived from magma-related fluid,and the metallogenic materials are most likely derived from the mixing source of the crust and the mantle.The Erlihe Pb-Zn deposit and associated dioritic porphyrite vein,important records of Qinling tectonic-magmatism-mineralization activities,were formed during the Triassic collisional orogeny processes.
基金the National Natural Science Foundation of China(No.40172021)the Major State Basic Research Program of the People’s Republic of China(No.G1999043211)the New Round Geological Survey Project (DKD9902001,2001BA609A-07-04).
文摘An isochron age of 282±20 (95% conf. limit) Ma of the sulfide ores in the Huangshandong Cu-Ni sulfide deposit, the East Tianshan Mountains has been obtained through Re-Os isotopic measurement. The age implies that the Cu-Ni sulfide deposit and other related deposits in the same area occurred in a Permian extensional environment of post-collision instead of Devonian-Early Carboniferous ophiolite-related oceanic or island arc environments inferred before. It shares the same ages with the orogenic and epithermal gold deposit systems in the same area. An initial 187Os/188Os ratio of 0.25±0.04 (1σ) and a γos value of 99 on average display the participation of large quantities of crustal components into the rock-forming and ore-forming system during mineralization and magmatic emplacement.
