AIM: To study the effects of low-dose amitriptyline (AMT) on gastrointestinal function and brain-gut peptides in healthy Chinese volunteers. METHODS: This was a double-blind, randomised, placebo-controlled, two-period...AIM: To study the effects of low-dose amitriptyline (AMT) on gastrointestinal function and brain-gut peptides in healthy Chinese volunteers. METHODS: This was a double-blind, randomised, placebo-controlled, two-period cross-over trial. Twentyeight healthy volunteers were randomised and administered 1-wk treatments of AMT (12.5 mg tid) or placebo. Before and during the final two days of treatment, gastric emptying, proximal gastric accommodation and visceral sensitivity were measured by drinkingultrasonography test; the orocecal transit time (OCTT) was measured by lactulose hydrogen breath test, and fasting blood was collected. Plasma levels of ghrelin, motilin and neuropeptide Y (NPY) were measured by enzyme-linked immunosorbent assay kits.RESULTS: AMT slowed the OCTT (109.2 ± 29.68 min vs 96.61 ± 23.9 min, P = 0.004) but did not affect liquid gastric emptying and had no effect on proximal gastric accommodation. AMT resulted in decreases in the visual analogue scale (VAS) for difficulty in drinking 600 and 800 mL of water (3.57 ± 0.94 vs 2.98 ± 0.85, 5.57 ± 0.82 vs 4.57 ± 0.98, P < 0.01 for both), although it had no significant effect on the VAS for difficulty in drinking 200 mL and 400 mL of water. AMT significantly increased the plasma ghrelin level (442.87 ± 176.79 pg/mL vs 526.87 ± 158.44 pg/mL, P = 0.04) and the neuropeptide-Y level (890.15 ± 131.46 pg/mL vs 965.64 ± 165.63 pg/mL, P = 0.03), whereas it had no effect on the MTL level. CONCLUSION: Low-dose AMT could slow OCTT, make the stomach less sensitive and increase the plasma levels of ghrelin and NPY. Thus, we recommend the use of low-dose AMT for functional gastrointestinal disorders.展开更多
目的:研究两种亚型功能性消化不良(functional d y s p e p s i a,F D)患者的口盲传递时间,探讨性别、年龄、体质量指数(body mass index,BMI)对口盲传递时间的影响.方法:对25例餐后不适综合征(postprandial distress syndrome,PDS)患者...目的:研究两种亚型功能性消化不良(functional d y s p e p s i a,F D)患者的口盲传递时间,探讨性别、年龄、体质量指数(body mass index,BMI)对口盲传递时间的影响.方法:对25例餐后不适综合征(postprandial distress syndrome,PDS)患者、22例上腹痛综合征(epigastric pain syndrome,EPS)患者及20例健康对照者进行氢呼吸实验,记录口盲传递时间(orocecal transit time,OCTT).结果:(1)PDS组的OCTT较健康组明显延长,而EPS组与健康组无显著差异;(2)三个实验组中,不同性别之间的OCTT均无显著差异;(3)健康组中,年龄与OCTT呈正相关,PDS组及EPS组中无该相关性;(4)健康组中,BMI与OCTT呈正相关;PDS组及EPS组中无该相关性.结论:PDS患者的小肠传输功能明显下降;年龄及BMI对健康人的OCTT有一定影响,而对PDS患者及EPS患者无显著影响.展开更多
文摘AIM: To study the effects of low-dose amitriptyline (AMT) on gastrointestinal function and brain-gut peptides in healthy Chinese volunteers. METHODS: This was a double-blind, randomised, placebo-controlled, two-period cross-over trial. Twentyeight healthy volunteers were randomised and administered 1-wk treatments of AMT (12.5 mg tid) or placebo. Before and during the final two days of treatment, gastric emptying, proximal gastric accommodation and visceral sensitivity were measured by drinkingultrasonography test; the orocecal transit time (OCTT) was measured by lactulose hydrogen breath test, and fasting blood was collected. Plasma levels of ghrelin, motilin and neuropeptide Y (NPY) were measured by enzyme-linked immunosorbent assay kits.RESULTS: AMT slowed the OCTT (109.2 ± 29.68 min vs 96.61 ± 23.9 min, P = 0.004) but did not affect liquid gastric emptying and had no effect on proximal gastric accommodation. AMT resulted in decreases in the visual analogue scale (VAS) for difficulty in drinking 600 and 800 mL of water (3.57 ± 0.94 vs 2.98 ± 0.85, 5.57 ± 0.82 vs 4.57 ± 0.98, P < 0.01 for both), although it had no significant effect on the VAS for difficulty in drinking 200 mL and 400 mL of water. AMT significantly increased the plasma ghrelin level (442.87 ± 176.79 pg/mL vs 526.87 ± 158.44 pg/mL, P = 0.04) and the neuropeptide-Y level (890.15 ± 131.46 pg/mL vs 965.64 ± 165.63 pg/mL, P = 0.03), whereas it had no effect on the MTL level. CONCLUSION: Low-dose AMT could slow OCTT, make the stomach less sensitive and increase the plasma levels of ghrelin and NPY. Thus, we recommend the use of low-dose AMT for functional gastrointestinal disorders.
文摘目的:研究两种亚型功能性消化不良(functional d y s p e p s i a,F D)患者的口盲传递时间,探讨性别、年龄、体质量指数(body mass index,BMI)对口盲传递时间的影响.方法:对25例餐后不适综合征(postprandial distress syndrome,PDS)患者、22例上腹痛综合征(epigastric pain syndrome,EPS)患者及20例健康对照者进行氢呼吸实验,记录口盲传递时间(orocecal transit time,OCTT).结果:(1)PDS组的OCTT较健康组明显延长,而EPS组与健康组无显著差异;(2)三个实验组中,不同性别之间的OCTT均无显著差异;(3)健康组中,年龄与OCTT呈正相关,PDS组及EPS组中无该相关性;(4)健康组中,BMI与OCTT呈正相关;PDS组及EPS组中无该相关性.结论:PDS患者的小肠传输功能明显下降;年龄及BMI对健康人的OCTT有一定影响,而对PDS患者及EPS患者无显著影响.
