AIM： To predict the visual outcome in patients undergoing macular hole surgery by two novel three-dimensional morphological parameters on optical coherence tomography （OCT）： area ratio factor （ARF） and volume ra...AIM： To predict the visual outcome in patients undergoing macular hole surgery by two novel three-dimensional morphological parameters on optical coherence tomography （OCT）： area ratio factor （ARF） and volume ratio factor （VRF）. METHODS： A clinical case series was conducted, including 54 eyes of 54 patients with an idiopathic macular hole （IMH）. Each patient had an OCT examination before and after surgery. Morphological parameters of the macular hole, such as minimum diameter, base diameter, and height were measured. Then, the macular hole index （Mill）, tractional hole index （THI）, and hole form factor （HFF） were calculated. Meanwhile, novel postoperative macular hole （MH） factors, ARF and VRF were calculated by three-dimensional morphology. Bivariate correlations were performed to acquire asymptotic significance values between the steady best corrected visual acuity （BCVA） after surgery and 2D/3D arguments of MH by the Pearson method with two-tailed test. All significant factors were analyzed by the receiver operating characteristic （ROC） curve analysis of SPSS software which were responsible for vision recovery. ROC curves analyses were performed to further discuss the different parameters on the prediction of visual outcome. RESULTS： The mean and standard deviation values of patients＇ age, symptoms duration, and follow-up time were 64.8＋8.9y （range： 28-81）, 18.6＋11.5d （range： 2-60）, and 11.4＋0.4mo （range： 6-24）, respectively. Steady-post-BCVA analyzed with bivariate correlations was found to be significantly correlated with base diameter （r＇0.521, P〈0.001）, minimum diameter （r=0.514, P〈0.001）, MHI （r -0.531, P〈0.001）, THI （r=-0.386, P=-0.004）, HFF （r=-0.508, P〈0.001）, and ARF （r=-0.532, P〈0.001）. Other characteristic parameters such as age, duration of surgery, height, diameter hole index, and VRF were not statistically significant with steady-post-BCVA. According to area under the curve （AUC） va展开更多
目的采用文献计量学方法分析2013—2023年生物膜与牙周炎相关的研究现状和热点。方法在Web of Science(Wos)数据库中检索生物膜与牙周炎相关文献,并运用VOSviewer和CiteSpace等可视化软件来分析国家/地区、作者、机构、期刊及关键词。...目的采用文献计量学方法分析2013—2023年生物膜与牙周炎相关的研究现状和热点。方法在Web of Science(Wos)数据库中检索生物膜与牙周炎相关文献,并运用VOSviewer和CiteSpace等可视化软件来分析国家/地区、作者、机构、期刊及关键词。结果共纳入1821篇文献,结果显示文献发文量逐年上升。发文量排名前3位的国家是美国、巴西和中国;排名前3位的机构是圣保罗大学、哈佛大学和福赛斯研究所;发文量最高的作者是Feres Magda;在发文量前10位的期刊中,Journal of Periodontology的发文量最多(87篇),其次是Plos One(69篇)和Clinical Oral Investigations(51篇)。氧化应激、标志物、辅助治疗及药物缓释是最主要的研究热点;前沿主要集中于群体感应、光动力疗法、活性氧、铜纳米颗粒及光学相干层析成像。结论生物膜和牙周炎的研究在逐年增长,未来的研究方向可重点关注氧化应激、辅助治疗、群体感应及光动力疗法。展开更多
基金Supported by National Natural Science Foundation of China(No.61675124No.81501559)+1 种基金Natural Science Foundation of the Higher Education Institutions of Jiangsu Province,China(No.15KJB310015)Science and Technology Foundation of Nantong Technology Bureau(No.MS12015180)
文摘AIM： To predict the visual outcome in patients undergoing macular hole surgery by two novel three-dimensional morphological parameters on optical coherence tomography （OCT）： area ratio factor （ARF） and volume ratio factor （VRF）. METHODS： A clinical case series was conducted, including 54 eyes of 54 patients with an idiopathic macular hole （IMH）. Each patient had an OCT examination before and after surgery. Morphological parameters of the macular hole, such as minimum diameter, base diameter, and height were measured. Then, the macular hole index （Mill）, tractional hole index （THI）, and hole form factor （HFF） were calculated. Meanwhile, novel postoperative macular hole （MH） factors, ARF and VRF were calculated by three-dimensional morphology. Bivariate correlations were performed to acquire asymptotic significance values between the steady best corrected visual acuity （BCVA） after surgery and 2D/3D arguments of MH by the Pearson method with two-tailed test. All significant factors were analyzed by the receiver operating characteristic （ROC） curve analysis of SPSS software which were responsible for vision recovery. ROC curves analyses were performed to further discuss the different parameters on the prediction of visual outcome. RESULTS： The mean and standard deviation values of patients＇ age, symptoms duration, and follow-up time were 64.8＋8.9y （range： 28-81）, 18.6＋11.5d （range： 2-60）, and 11.4＋0.4mo （range： 6-24）, respectively. Steady-post-BCVA analyzed with bivariate correlations was found to be significantly correlated with base diameter （r＇0.521, P〈0.001）, minimum diameter （r=0.514, P〈0.001）, MHI （r -0.531, P〈0.001）, THI （r=-0.386, P=-0.004）, HFF （r=-0.508, P〈0.001）, and ARF （r=-0.532, P〈0.001）. Other characteristic parameters such as age, duration of surgery, height, diameter hole index, and VRF were not statistically significant with steady-post-BCVA. According to area under the curve （AUC） va
文摘目的 观察非增生型糖尿病视网膜病变（NPDR）黄斑水肿（DME）伴发浆液性黄斑脱离（SMD）的脉络膜微结构改变的光相干断层扫描图像（OCT）特征。方法 NPDR单眼发生DME伴SMD （SMD组）的9只眼以及对侧只有DME而无SMD（无SMD组）的9只眼纳入研究。患者中，既往行全视网膜激光光凝（PRP）治疗6只眼，按是否行PRP治疗分为PRP治疗组和非PRP治疗组，分别为6、12只眼。均行增强深部成像技术（EDI）频域光相干断层扫描（EDI-OCT）和眼底彩色照相检查。测量中心凹处脉络膜厚度，应用Image Plus Pro 6.0 软件计算以中心凹为中心的EDI-OCT水平扫描所提示的脉络膜模拟面积。采用配对t检验对比分析有无SMD眼检测结果的差异；F检验对比分析PRP治疗组与非PRP治疗组间差异。结果 SMD组视网膜神经上皮脱离区域呈梭型或圆顶状的低信号暗区，外界膜均保持完整，光感受器内外节连接层与视网膜色素上皮-Bruch膜之间发生分离。SMD组中心凹脉络膜平均厚度和脉络膜平均模拟面积均高于无SMD组，差异有统计学意义（t=2.306、2.306，P＜0.05）。PRP治疗组脉络膜平均模拟面积大于非PRP治疗组脉络膜平均模拟面积，差异有统计学意义（F=5.227，P＜0.05）；两组间中心凹脉络膜平均厚度比较，差异无统计学意义（F=3.276，P＞0.05）。结论 NPDR中DME伴发SMD眼脉络膜微结构改变的OCT图像特征是视网膜神经上皮脱离区域呈梭型或圆顶状的弱信号暗区。
文摘目的采用文献计量学方法分析2013—2023年生物膜与牙周炎相关的研究现状和热点。方法在Web of Science(Wos)数据库中检索生物膜与牙周炎相关文献,并运用VOSviewer和CiteSpace等可视化软件来分析国家/地区、作者、机构、期刊及关键词。结果共纳入1821篇文献,结果显示文献发文量逐年上升。发文量排名前3位的国家是美国、巴西和中国;排名前3位的机构是圣保罗大学、哈佛大学和福赛斯研究所;发文量最高的作者是Feres Magda;在发文量前10位的期刊中,Journal of Periodontology的发文量最多(87篇),其次是Plos One(69篇)和Clinical Oral Investigations(51篇)。氧化应激、标志物、辅助治疗及药物缓释是最主要的研究热点;前沿主要集中于群体感应、光动力疗法、活性氧、铜纳米颗粒及光学相干层析成像。结论生物膜和牙周炎的研究在逐年增长,未来的研究方向可重点关注氧化应激、辅助治疗、群体感应及光动力疗法。
