This article describes the use of a boron-doped diamond electrode (BDDE) as an electrochemical sensor for the simultaneous determination of omnipaque (OMP) and paracetamol (PCM) in perchloric acid medium (HClO4 0.1 M)...This article describes the use of a boron-doped diamond electrode (BDDE) as an electrochemical sensor for the simultaneous determination of omnipaque (OMP) and paracetamol (PCM) in perchloric acid medium (HClO4 0.1 M) and in complex matrices such as tomato, carrot and cucumber juices and waste water from the Treichville University Hospital. Voltammetric studies allowed us to have well-defined oxidation peaks at distinct potentials of OMP (E = 0.5 V/SCE) and PCM (E = 0.7 V/SCE). Under optimized conditions, well-defined quantities of OMP and PCM, introduced simultaneously by metered additions, gave linear responses in concentration ranges of 259.8 - 467.2 μM for OMP and 58.73 - 116.3 μM PCM. The detection limits obtained are 7.23 μΜ and 3.6 μΜ respectively for OMP and PCM with recovery rates between 85.8% ± 0.1% and 92.6% ± 0.1% for OMP and between 99.9% ± 0.1% and 101.2% ± 0.4% for the PCM. This technique has been successfully used to simultaneously detect these pharmaceuticals in these complex environments. It allows recovery of OMP and PCM respectively up to 97.5% ± 0.0% and 91.6% ± 0.3% in tomato juice;100.0% ± 0.0% and 95.2% ± 0.2% in carrot juice;101.4% ± 0.1% and 97.3% ± 0.3% in cucumber juice;100.1% ± 0.9% and 100.9% ± 0.1% in wastewater. The relevance of this technique for the simultaneous detection of OMP and PCM in tomato, carrot, cucumber juices and in waste water can be studied in the context of the contamination of certain fruits and vegetables by the substances organic pharmaceuticals released into the environment without prior treatment.展开更多
目的:探讨泛影葡胺与欧乃派克在不孕症子宫输卵管造影检查中的应用价值。方法:选取2014年5月—2016年4月我院收治的80例输卵管性不孕症患者作为研究对象,按随机数字表法分为两组,各40例。对照组采用泛影葡胺(10 m L,碘浓度为76%)造影,...目的:探讨泛影葡胺与欧乃派克在不孕症子宫输卵管造影检查中的应用价值。方法:选取2014年5月—2016年4月我院收治的80例输卵管性不孕症患者作为研究对象,按随机数字表法分为两组,各40例。对照组采用泛影葡胺(10 m L,碘浓度为76%)造影,观察组采用欧乃派克(10 m L,碘浓度为300 mg/m L)造影。观察比较两组造影图像质量、不良反应及疼痛程度。结果:观察组造影图像优良率为97.50%(39/40)高于对照组的77.50%(31/40),差异有统计学意义(P<0.05);造影后,观察组不良反应总发生率为7.50%(3/40)低于对照组的25.00%(10/40)(P<0.05);观察组视觉模拟评分法(VAS)评分低于对照组(P<0.05)。结论:在不孕症子宫输卵管造影检查中,相较于泛影葡胺,欧乃派克造影图像质量更佳,能有效减少不良反应发生率,减轻疼痛,值得临床推广。展开更多
文摘This article describes the use of a boron-doped diamond electrode (BDDE) as an electrochemical sensor for the simultaneous determination of omnipaque (OMP) and paracetamol (PCM) in perchloric acid medium (HClO4 0.1 M) and in complex matrices such as tomato, carrot and cucumber juices and waste water from the Treichville University Hospital. Voltammetric studies allowed us to have well-defined oxidation peaks at distinct potentials of OMP (E = 0.5 V/SCE) and PCM (E = 0.7 V/SCE). Under optimized conditions, well-defined quantities of OMP and PCM, introduced simultaneously by metered additions, gave linear responses in concentration ranges of 259.8 - 467.2 μM for OMP and 58.73 - 116.3 μM PCM. The detection limits obtained are 7.23 μΜ and 3.6 μΜ respectively for OMP and PCM with recovery rates between 85.8% ± 0.1% and 92.6% ± 0.1% for OMP and between 99.9% ± 0.1% and 101.2% ± 0.4% for the PCM. This technique has been successfully used to simultaneously detect these pharmaceuticals in these complex environments. It allows recovery of OMP and PCM respectively up to 97.5% ± 0.0% and 91.6% ± 0.3% in tomato juice;100.0% ± 0.0% and 95.2% ± 0.2% in carrot juice;101.4% ± 0.1% and 97.3% ± 0.3% in cucumber juice;100.1% ± 0.9% and 100.9% ± 0.1% in wastewater. The relevance of this technique for the simultaneous detection of OMP and PCM in tomato, carrot, cucumber juices and in waste water can be studied in the context of the contamination of certain fruits and vegetables by the substances organic pharmaceuticals released into the environment without prior treatment.
文摘目的:探讨泛影葡胺与欧乃派克在不孕症子宫输卵管造影检查中的应用价值。方法:选取2014年5月—2016年4月我院收治的80例输卵管性不孕症患者作为研究对象,按随机数字表法分为两组,各40例。对照组采用泛影葡胺(10 m L,碘浓度为76%)造影,观察组采用欧乃派克(10 m L,碘浓度为300 mg/m L)造影。观察比较两组造影图像质量、不良反应及疼痛程度。结果:观察组造影图像优良率为97.50%(39/40)高于对照组的77.50%(31/40),差异有统计学意义(P<0.05);造影后,观察组不良反应总发生率为7.50%(3/40)低于对照组的25.00%(10/40)(P<0.05);观察组视觉模拟评分法(VAS)评分低于对照组(P<0.05)。结论:在不孕症子宫输卵管造影检查中,相较于泛影葡胺,欧乃派克造影图像质量更佳,能有效减少不良反应发生率,减轻疼痛,值得临床推广。