Objective： To investigate the efficacy and mechanisms of moxibustion-based treatment of chronic gastritis （CG）, and to provide an objective basis for treating CG using moxibustion. Methods： A total of 61 CG patien...Objective： To investigate the efficacy and mechanisms of moxibustion-based treatment of chronic gastritis （CG）, and to provide an objective basis for treating CG using moxibustion. Methods： A total of 61 CG patients were divided into an herbal cake-partitioned moxibustion group and a mild-warm moxibustion group. In both treatment groups, bilateral Tianshu （ST 25）, Zhongwan （CV 12） and Qihai （CV 6） were selected for moxibustion. Before and after treatment, all the enrolled patients＇ gastrointestinal disease-related traditional Chinese medicine （TCM） syndrome scores and visual analog scale （VAS） scores were measured, and the changes in the serum levels of the brain-gut peptides ghrelin, somatostatin （SS） and motilin （MTL） were observed. Results： There was no statistically significant difference between the two groups in the clinical efficacy rate （P〈0.05）. After treatment, the gastrointestinal disease-related TCM syndrome scores and VAS scores were reduced to varying extents in both groups, the intra-group differences were statistically significant （all P〈0.01）. In both groups, the serum levels of ghrelin and MTL increased and the serum levels of SS decreased after treatment （all P〈0.01）. And there were no serious adverse events occurred. Conclusion： Both herbal cake-partitioned moxibustion and mild-warm moxibustion are effective for CG, these two therapies exhibited similar therapeutic efficacy of epigastric discomfort or pain. And both the two therapies act to anti-inflammation, promote the recovery of gastric mucosa and improve the gastric motility, which is possibly their crucial action mechanism in treating CD.展开更多
Objective：To observe the effect of herbal-partitioned moxibustion （HPM） on pain-related behavior and emotion in a rat model of chronic inflammatory visceral pain, and to investigate the mechanism. 〈br〉 Methods：T...Objective：To observe the effect of herbal-partitioned moxibustion （HPM） on pain-related behavior and emotion in a rat model of chronic inflammatory visceral pain, and to investigate the mechanism. 〈br〉 Methods：Twenty-four male Sprague-Dawley （SD） rats were randomly divided into three groups：a normal group, a model group and an HPM group. Except for the normal group, rats in the other two groups were clystered with mixed liquor of Trinitrobenzene Sulfonic Acid （TNBS） and 50%ethanol to induce the chronic inflammatory visceral pain model. After the models were established successfully, rats in the HPM group were treated with HPM at bilateral Tianshu （ST 25） and Qihai （CV 6）. Rats in the normal group and the model group were only fixed as those in the HPM group without treatment. Abdominal withdrawal reflex （AWR） score, mechanical withdrawal threshold （MWT） and thermal withdrawal latency （TWL） were adopted to detect the visceral and somatic pain;meanwhile, open field test （OFT） and elevated plus maze test （EPMT） were employed to evaluate pain emotions such as depression and anxiety. 〈br〉 Results：Compared with the normal group, AWR scores of the model group were significantly increased under different stimulus expansion pressure level （P〈0.01）, MWT and TWL were significantly decreased （P〈0.05）;in OFT, the values of horizontal activities and vertical activities were significantly decreased （P〈0.01）;in EPMT, the proportion of the number of entry into the open arms （OE%） and that of residence time in the open arms （OT%） significantly decreased （P〈0.01）, indicating that the model was successful. Compared with the model group, the AWR score of the HPM group was decreased significantly （P〈0.05）, MWT and TWL were significantly increased （P〈0.05）, the values of horizontal activities and vertical activities in the model group were significantly increased （P〈0.01）;in OFT and EPMT, OE%and OT%were significantly increased （P展开更多
基金supported by This scientific work was supported by the Foundation of Shanghai Municipal Health Bureau(No.20124071)National Basic Research Program of China 973 Program(No.2009CB522900)~~
文摘Objective： To investigate the efficacy and mechanisms of moxibustion-based treatment of chronic gastritis （CG）, and to provide an objective basis for treating CG using moxibustion. Methods： A total of 61 CG patients were divided into an herbal cake-partitioned moxibustion group and a mild-warm moxibustion group. In both treatment groups, bilateral Tianshu （ST 25）, Zhongwan （CV 12） and Qihai （CV 6） were selected for moxibustion. Before and after treatment, all the enrolled patients＇ gastrointestinal disease-related traditional Chinese medicine （TCM） syndrome scores and visual analog scale （VAS） scores were measured, and the changes in the serum levels of the brain-gut peptides ghrelin, somatostatin （SS） and motilin （MTL） were observed. Results： There was no statistically significant difference between the two groups in the clinical efficacy rate （P〈0.05）. After treatment, the gastrointestinal disease-related TCM syndrome scores and VAS scores were reduced to varying extents in both groups, the intra-group differences were statistically significant （all P〈0.01）. In both groups, the serum levels of ghrelin and MTL increased and the serum levels of SS decreased after treatment （all P〈0.01）. And there were no serious adverse events occurred. Conclusion： Both herbal cake-partitioned moxibustion and mild-warm moxibustion are effective for CG, these two therapies exhibited similar therapeutic efficacy of epigastric discomfort or pain. And both the two therapies act to anti-inflammation, promote the recovery of gastric mucosa and improve the gastric motility, which is possibly their crucial action mechanism in treating CD.
基金supported by National Natural Science Foundation of China(No.81273843)National Basic Research Program of China(973 Program,No.2009CB522900)Project of Shanghai Municipality Health Bureau(No.20144Y0153,No.20124Y004)
文摘Objective：To observe the effect of herbal-partitioned moxibustion （HPM） on pain-related behavior and emotion in a rat model of chronic inflammatory visceral pain, and to investigate the mechanism. 〈br〉 Methods：Twenty-four male Sprague-Dawley （SD） rats were randomly divided into three groups：a normal group, a model group and an HPM group. Except for the normal group, rats in the other two groups were clystered with mixed liquor of Trinitrobenzene Sulfonic Acid （TNBS） and 50%ethanol to induce the chronic inflammatory visceral pain model. After the models were established successfully, rats in the HPM group were treated with HPM at bilateral Tianshu （ST 25） and Qihai （CV 6）. Rats in the normal group and the model group were only fixed as those in the HPM group without treatment. Abdominal withdrawal reflex （AWR） score, mechanical withdrawal threshold （MWT） and thermal withdrawal latency （TWL） were adopted to detect the visceral and somatic pain;meanwhile, open field test （OFT） and elevated plus maze test （EPMT） were employed to evaluate pain emotions such as depression and anxiety. 〈br〉 Results：Compared with the normal group, AWR scores of the model group were significantly increased under different stimulus expansion pressure level （P〈0.01）, MWT and TWL were significantly decreased （P〈0.05）;in OFT, the values of horizontal activities and vertical activities were significantly decreased （P〈0.01）;in EPMT, the proportion of the number of entry into the open arms （OE%） and that of residence time in the open arms （OT%） significantly decreased （P〈0.01）, indicating that the model was successful. Compared with the model group, the AWR score of the HPM group was decreased significantly （P〈0.05）, MWT and TWL were significantly increased （P〈0.05）, the values of horizontal activities and vertical activities in the model group were significantly increased （P〈0.01）;in OFT and EPMT, OE%and OT%were significantly increased （P
