目的建立S.O.L.V.E.评分系统,探讨其预测输尿管软镜治疗上尿路结石术后结石清除率(SFR)的价值。方法建立S.O.L.V.E.评分系统,共纳入5个预测变量:结石表面积(stonesurfacearea,S)、梗阻程度(obstruction,O)、肾盏...目的建立S.O.L.V.E.评分系统,探讨其预测输尿管软镜治疗上尿路结石术后结石清除率(SFR)的价值。方法建立S.O.L.V.E.评分系统,共纳入5个预测变量:结石表面积(stonesurfacearea,S)、梗阻程度(obstruction,O)、肾盏漏斗部长度(1ength of calyces funnel,L)、累及肾盏数(visible number of calyces,V)、结石密度(essence of stone,E)。回顾性分析2017年1月至2018年6月收治的392例行输尿管软镜治疗的上尿路结石患者的临床资料,男258例,女134例。年龄15-85岁,平均(49.5±12.6)岁。根据术后结石残留情况,分为无残留组292例,男197例,女95例;平均年龄(49.2±12.8)岁;既往有结石手术史37例;中位体重指数24.7kg/m^2(18.1-29.0kg/m^2);术前血肌酐中位值72.5μmol/L(48.9-84.8μmol/L);结石位于左侧155例,右侧137例;结石位于输尿管19例,肾盂16例,肾下盏87例,肾下盏以外肾盏170例。结石残留组100例,男61例,女39例;平均年龄(50.4±12.0)岁;中位体重指数25.0kg/m^2(18.5-28.8kg/m^2);术前血肌酐中位值73.8μmol/L(46.5-92.5Iμmol/L);既往有结石手术史15例;结石位于左侧51例,右侧49例;结石位于输尿管7例,肾盂4例,肾下盏27例,肾下盏以外肾盏62例。基于392例术前泌尿系CT平扫+三维重建影像学资料,对S.O.L.V.E.评分系统5个预测变量进行测量,并对患者结石特征进行评分。比较无残留组和残留组S.O.L.V.E.评分各项指标的差异。根据S.O.L.V.E.评分将患者分为低分组(4-5分)、中分组(6-8分)、高分组(9-11)。比较不同S.O.L.V.E.评分组间术后SFR、术后住院时间、术后并发症、手术时间的差异。采用受试者工作特征曲线(ROC)检测S.O.L.V.E.评分系统预测SFR的价值。结果本研究392例手展开更多
Four structurally unprecedented aconitane-type C_(19)-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A–D(1–4), were isolated from an aqueous extract of "fu zi", the lateral...Four structurally unprecedented aconitane-type C_(19)-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A–D(1–4), were isolated from an aqueous extract of "fu zi", the lateral roots of Aconitum carmichaelii. Their structures were determined as neoline 14-O-a-and 14-O-b-L-arabinopyranosides(1 and 2) and 14-O-a-and 14-O-b-L-arabinofuranosides(3 and 4), by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1–4 represent the first examples of glycosidic diterpenoid alkaloids.展开更多
文摘目的建立S.O.L.V.E.评分系统,探讨其预测输尿管软镜治疗上尿路结石术后结石清除率(SFR)的价值。方法建立S.O.L.V.E.评分系统,共纳入5个预测变量:结石表面积(stonesurfacearea,S)、梗阻程度(obstruction,O)、肾盏漏斗部长度(1ength of calyces funnel,L)、累及肾盏数(visible number of calyces,V)、结石密度(essence of stone,E)。回顾性分析2017年1月至2018年6月收治的392例行输尿管软镜治疗的上尿路结石患者的临床资料,男258例,女134例。年龄15-85岁,平均(49.5±12.6)岁。根据术后结石残留情况,分为无残留组292例,男197例,女95例;平均年龄(49.2±12.8)岁;既往有结石手术史37例;中位体重指数24.7kg/m^2(18.1-29.0kg/m^2);术前血肌酐中位值72.5μmol/L(48.9-84.8μmol/L);结石位于左侧155例,右侧137例;结石位于输尿管19例,肾盂16例,肾下盏87例,肾下盏以外肾盏170例。结石残留组100例,男61例,女39例;平均年龄(50.4±12.0)岁;中位体重指数25.0kg/m^2(18.5-28.8kg/m^2);术前血肌酐中位值73.8μmol/L(46.5-92.5Iμmol/L);既往有结石手术史15例;结石位于左侧51例,右侧49例;结石位于输尿管7例,肾盂4例,肾下盏27例,肾下盏以外肾盏62例。基于392例术前泌尿系CT平扫+三维重建影像学资料,对S.O.L.V.E.评分系统5个预测变量进行测量,并对患者结石特征进行评分。比较无残留组和残留组S.O.L.V.E.评分各项指标的差异。根据S.O.L.V.E.评分将患者分为低分组(4-5分)、中分组(6-8分)、高分组(9-11)。比较不同S.O.L.V.E.评分组间术后SFR、术后住院时间、术后并发症、手术时间的差异。采用受试者工作特征曲线(ROC)检测S.O.L.V.E.评分系统预测SFR的价值。结果本研究392例手
基金Financial support from the National Natural Science Foundation of China(NNSFC,Nos.81630094 and 30825044)
文摘Four structurally unprecedented aconitane-type C_(19)-diterpenoid alkaloid glycosides with isomeric arabinosyls, named aconicarmichosides A–D(1–4), were isolated from an aqueous extract of "fu zi", the lateral roots of Aconitum carmichaelii. Their structures were determined as neoline 14-O-a-and 14-O-b-L-arabinopyranosides(1 and 2) and 14-O-a-and 14-O-b-L-arabinofuranosides(3 and 4), by spectroscopic and chemical methods including 2D NMR experiments and acid hydrolysis. Compounds 1–4 represent the first examples of glycosidic diterpenoid alkaloids.