近几年来,随着巴西亚马逊流域考古发现黑土(black earths,或terra preta de indio(葡萄牙语))及研究的深入,认为将生物质炭化还田不仅能藏碳于土,减缓全球气候变化,而且能提高全球粮食安全保障。生物质在无氧或低氧条件下高温裂解炭化...近几年来,随着巴西亚马逊流域考古发现黑土(black earths,或terra preta de indio(葡萄牙语))及研究的深入,认为将生物质炭化还田不仅能藏碳于土,减缓全球气候变化,而且能提高全球粮食安全保障。生物质在无氧或低氧条件下高温裂解炭化而成的产物被称为生物炭(biochar)。本文将从生物炭特性;生物炭对作物产量和养分吸收的影响;生物炭分解和对土壤碳周转的影响以及对污染物降解和生物有效性影响方面进行综述,以期为国内生物炭研究提供参考。展开更多
The cystine/glutamate antiporter SLC7A11(also commonly known as xCT)functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.Recent studies reveal...The cystine/glutamate antiporter SLC7A11(also commonly known as xCT)functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.Recent studies revealed that SLC7A11 overexpression promotes tumor growth partly through suppressing ferroptosis,a form of regulated cell death induced by excessive lipid peroxidation.However,cancer cells with high expression of SLC7A11(SLC7A11^(high))also have to endure the significant cost associated with SLC7A11-mediated metabolic reprogramming,leading to glucose-and glutamine-dependency in SLC7A11^(high) cancer cells,which presents potential metabolic vulnerabilities for therapeutic targeting in SLC7A11^(high) cancer.In this review,we summarize diverse regulatory mechanisms of SLC7A11 in cancer,discuss ferroptosis-dependent and-independent functions of SLC7A11 in promoting tumor development,explore the mechanistic basis of SLC7A11-induced nutrient dependency in cancer cells,and conceptualize therapeutic strategies to target SLC7A11 in cancer treatment.This review will provide the foundation for further understanding SLC7A11 in ferroptosis,nutrient dependency,and tumor biology and for developing novel effective cancer therapies.展开更多
The homeostasis of free radicals is vital to the evolution and life of oxygen-requiring organisms. Under normal physiological conditions, rates of the production of free radicals are virtually equal to rates of their ...The homeostasis of free radicals is vital to the evolution and life of oxygen-requiring organisms. Under normal physiological conditions, rates of the production of free radicals are virtually equal to rates of their removal. The cytotoxic effect of free radicals is deleterious to cells and mediates the pathogenesis of a wide array of diseases. Therefore, antioxidants (e.g. vitamin C, vitamin E, β-carotene, and glutathione) are essential to the survival, health, and reproduction of animals, including humans. Antioxidants may be classified as nutritionally essential (e.g. vitamin antioxidants), indirectly essential (e.g., dietary fibre), conditionally essential (e.g. flavonoids and other effective phytochemicals) or non-essential. In the body, appropriate nutrition should not only prevent diseases, but also promote free radical homeostasis. Thus, it is crucial to develop useful indicators of oxidative stress, such as the cellular ratio of /, lipid peroxidation, oxidative modification of protein and DNA damage. On the basis of the recent report that the improper therapy of iron deficiency results in free radical-mediated dysfunction of the gastrointestinal tract, it is important to verify whether the formulated requirement of nutrients meet the need of maintaining the homeostasis of free radicals. The recommended intake of vitamin E, vitamin C and other antioxidants may need to be revised so as to protect the body against oxidative stress brought about by endogenous and exogenous factors. In order to delay aging and promote health in humans of all ages, and eliminate oxidative damage in response to the treatment of certain diseases, special nutritional measures should be taken. These measures may include the control of caloric intake, reduction in the absorption of free radicals and electrophilic substances, and adequate provision of antioxidant nutrients as well as effective phytochemicals and nutraceuticals. We predict that the concept of free radical biology will continue to greatly advance life sciences, inclu展开更多
Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit th...Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit the stress signals within cells as well as between cells and tissues,and make appropriate adjustments in their growth and development in order to survive and reproduce.In recent years,significant progress has been made on many fronts of the stress signaling research,particularly in understanding the downstream signaling events that culminate at the activation of stress-and nutrient limitation-responsive genes,cellular ion homeostasis,and growth adjustment.However,the revelation of the early events of stress signaling,particularly the identification of primary stress sensors,still lags behind.In this review,we summarize recent work on the genetic and molecular mechanisms of plant abiotic stress and nutrient limitation sensing and signaling and discuss new directions for future studies.展开更多
Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs,and to maintain redox homeostasis.One nutrient transporter frequently overexpressed in human cancers i...Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs,and to maintain redox homeostasis.One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11(SLC7A11;also known as xCT).SLC7A11 promotes cystine uptake and glutathione biosynthesis,resulting in protection from oxidative stress and ferroptotic cell death.Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells.This review discusses the roles of SLC7A11 in regulating the anti-oxidant response and nutrient dependency of cancer cells,explores our current understanding of SLC7A11 regulation in cancer metabolism,and highlights key open questions for future studies in this emerging research area.A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment.展开更多
当前农民过量和不平衡施用化肥现象严重,导致肥料利用率降低,影响到农田的可持续利用。因此,发展适合我国农业生产特点的养分管理和施肥方法尤为重要。本文介绍了基于作物产量反应和农学效率的推荐施肥新方法,该方法是以改进的SSNM(Site...当前农民过量和不平衡施用化肥现象严重,导致肥料利用率降低,影响到农田的可持续利用。因此,发展适合我国农业生产特点的养分管理和施肥方法尤为重要。本文介绍了基于作物产量反应和农学效率的推荐施肥新方法,该方法是以改进的SSNM(Site-specific Nutrient Management)和改进的QUEFTS(Quantitative Evaluation of the Fertility of Tropical Soils)模型参数为指导的养分管理和推荐施肥为原则,同时考虑大、中微量元素的全面平衡,并应用计算机软件技术把复杂和综合的养分管理原则智能化形成可为当地技术推广人员掌握的Nutrient Expert推荐施肥专家系统。Nutrient Expert推荐施肥专家系统在用户回答一些简单问题后就能给出基于作物栽培管理措施的推荐施肥套餐,包括作物种植密度、目标产量、推荐的养分用量及其可选用的物化的肥料用量,同时根据预知的作物生长季节推荐施肥的最佳时间和次数。通过跨区域田间多点验证试验证明,基于作物产量反应和农学效率的推荐施肥方法是一种简单的易于掌握的作物增产增收、提高肥料利用率和保护环境的新方法。展开更多
文摘近几年来,随着巴西亚马逊流域考古发现黑土(black earths,或terra preta de indio(葡萄牙语))及研究的深入,认为将生物质炭化还田不仅能藏碳于土,减缓全球气候变化,而且能提高全球粮食安全保障。生物质在无氧或低氧条件下高温裂解炭化而成的产物被称为生物炭(biochar)。本文将从生物炭特性;生物炭对作物产量和养分吸收的影响;生物炭分解和对土壤碳周转的影响以及对污染物降解和生物有效性影响方面进行综述,以期为国内生物炭研究提供参考。
基金The research in authors'lab has been supported by The University of Texas MD Anderson Cancer Center,KC180131 from Department of Defense Kidney Cancer Research Program,R01CA181196,R01CA190370,R01CA244144 from the National Institutes of Health(to BG)CPRIT Research Training Grant(RP170067)Dr.John J.Kopchick Research Award from The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences(to PK).
文摘The cystine/glutamate antiporter SLC7A11(also commonly known as xCT)functions to import cystine for glutathione biosynthesis and antioxidant defense and is overexpressed in multiple human cancers.Recent studies revealed that SLC7A11 overexpression promotes tumor growth partly through suppressing ferroptosis,a form of regulated cell death induced by excessive lipid peroxidation.However,cancer cells with high expression of SLC7A11(SLC7A11^(high))also have to endure the significant cost associated with SLC7A11-mediated metabolic reprogramming,leading to glucose-and glutamine-dependency in SLC7A11^(high) cancer cells,which presents potential metabolic vulnerabilities for therapeutic targeting in SLC7A11^(high) cancer.In this review,we summarize diverse regulatory mechanisms of SLC7A11 in cancer,discuss ferroptosis-dependent and-independent functions of SLC7A11 in promoting tumor development,explore the mechanistic basis of SLC7A11-induced nutrient dependency in cancer cells,and conceptualize therapeutic strategies to target SLC7A11 in cancer treatment.This review will provide the foundation for further understanding SLC7A11 in ferroptosis,nutrient dependency,and tumor biology and for developing novel effective cancer therapies.
文摘The homeostasis of free radicals is vital to the evolution and life of oxygen-requiring organisms. Under normal physiological conditions, rates of the production of free radicals are virtually equal to rates of their removal. The cytotoxic effect of free radicals is deleterious to cells and mediates the pathogenesis of a wide array of diseases. Therefore, antioxidants (e.g. vitamin C, vitamin E, β-carotene, and glutathione) are essential to the survival, health, and reproduction of animals, including humans. Antioxidants may be classified as nutritionally essential (e.g. vitamin antioxidants), indirectly essential (e.g., dietary fibre), conditionally essential (e.g. flavonoids and other effective phytochemicals) or non-essential. In the body, appropriate nutrition should not only prevent diseases, but also promote free radical homeostasis. Thus, it is crucial to develop useful indicators of oxidative stress, such as the cellular ratio of /, lipid peroxidation, oxidative modification of protein and DNA damage. On the basis of the recent report that the improper therapy of iron deficiency results in free radical-mediated dysfunction of the gastrointestinal tract, it is important to verify whether the formulated requirement of nutrients meet the need of maintaining the homeostasis of free radicals. The recommended intake of vitamin E, vitamin C and other antioxidants may need to be revised so as to protect the body against oxidative stress brought about by endogenous and exogenous factors. In order to delay aging and promote health in humans of all ages, and eliminate oxidative damage in response to the treatment of certain diseases, special nutritional measures should be taken. These measures may include the control of caloric intake, reduction in the absorption of free radicals and electrophilic substances, and adequate provision of antioxidant nutrients as well as effective phytochemicals and nutraceuticals. We predict that the concept of free radical biology will continue to greatly advance life sciences, inclu
文摘Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and quality.Plants have evolved mechanisms to perceive these environmental challenges,transmit the stress signals within cells as well as between cells and tissues,and make appropriate adjustments in their growth and development in order to survive and reproduce.In recent years,significant progress has been made on many fronts of the stress signaling research,particularly in understanding the downstream signaling events that culminate at the activation of stress-and nutrient limitation-responsive genes,cellular ion homeostasis,and growth adjustment.However,the revelation of the early events of stress signaling,particularly the identification of primary stress sensors,still lags behind.In this review,we summarize recent work on the genetic and molecular mechanisms of plant abiotic stress and nutrient limitation sensing and signaling and discuss new directions for future studies.
基金supported by the Andrew Sabin Family Fellow Award and Institutional Research Grant from the University of Texas MD Anderson Cancer Center,Grants from National Institutes of Health(CA181196 and CA190370)Anna Fuller Fund,and Ellison Medical Foundation(AG-NS-0973-13).
文摘Cancer cells often upregulate nutrient transporters to fulfill their increased biosynthetic and bioenergetic needs,and to maintain redox homeostasis.One nutrient transporter frequently overexpressed in human cancers is the cystine/glutamate antiporter solute carrier family 7 member 11(SLC7A11;also known as xCT).SLC7A11 promotes cystine uptake and glutathione biosynthesis,resulting in protection from oxidative stress and ferroptotic cell death.Recent studies have unexpectedly revealed that SLC7A11 also plays critical roles in glutamine metabolism and regulates the glucose and glutamine dependency of cancer cells.This review discusses the roles of SLC7A11 in regulating the anti-oxidant response and nutrient dependency of cancer cells,explores our current understanding of SLC7A11 regulation in cancer metabolism,and highlights key open questions for future studies in this emerging research area.A deeper understanding of SLC7A11 in cancer metabolism may identify new therapeutic opportunities to target this important amino acid transporter for cancer treatment.
文摘当前农民过量和不平衡施用化肥现象严重,导致肥料利用率降低,影响到农田的可持续利用。因此,发展适合我国农业生产特点的养分管理和施肥方法尤为重要。本文介绍了基于作物产量反应和农学效率的推荐施肥新方法,该方法是以改进的SSNM(Site-specific Nutrient Management)和改进的QUEFTS(Quantitative Evaluation of the Fertility of Tropical Soils)模型参数为指导的养分管理和推荐施肥为原则,同时考虑大、中微量元素的全面平衡,并应用计算机软件技术把复杂和综合的养分管理原则智能化形成可为当地技术推广人员掌握的Nutrient Expert推荐施肥专家系统。Nutrient Expert推荐施肥专家系统在用户回答一些简单问题后就能给出基于作物栽培管理措施的推荐施肥套餐,包括作物种植密度、目标产量、推荐的养分用量及其可选用的物化的肥料用量,同时根据预知的作物生长季节推荐施肥的最佳时间和次数。通过跨区域田间多点验证试验证明,基于作物产量反应和农学效率的推荐施肥方法是一种简单的易于掌握的作物增产增收、提高肥料利用率和保护环境的新方法。
