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细胞核力学生物学及其调控机制的研究进展
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作者 严然 陈祥燕 +3 位作者 张译兮 王梦 李顺 刘贻尧 《生物医学工程学杂志》 EI CAS 北大核心 2023年第4期617-624,共8页
细胞核作为细胞内重要的遗传与调控中心,不但是细胞内生化信号的终端效应器,还能在细胞感知并应答力学刺激后,通过直接或间接的核力学信号调节对细胞的功能与表型产生重要影响。细胞核依靠染色质—核膜—细胞骨架等基础结构将其与其他... 细胞核作为细胞内重要的遗传与调控中心,不但是细胞内生化信号的终端效应器,还能在细胞感知并应答力学刺激后,通过直接或间接的核力学信号调节对细胞的功能与表型产生重要影响。细胞核依靠染色质—核膜—细胞骨架等基础结构将其与其他胞内、外的物理微环境耦合,响应力学刺激并做出应答。该力学响应级联中,细胞核形态结构的变化是最直观的表现,也是细胞核直接响应力学刺激的基础。基于此类细胞核与细胞行为、表型的联系,核的异常形态变化被作为疾病诊断工具广泛用于临床实践。本文回顾了细胞核形变如何响应和适应力学刺激的证据,并着重综述了细胞核形变的力学调控因素,以及核形变涉及到的包括肿瘤在内的生理病理过程及其力学调控机制和研究进展,为深入理解细胞核力学参与的疾病发展调控机制和作为潜在靶点用于诊疗提供新的思路。 展开更多
关键词 细胞核形变 细胞骨架力学 核力学转导 染色质重构 肿瘤
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Mechanical Stress to Cell Nucleus Inhibits Proliferation and Differentiation of Vascular Smooth Muscle Cells
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作者 Kazuaki Nagayama 《Journal of Biosciences and Medicines》 2020年第5期132-141,共10页
Cells sense the external environment such as a surface topography and change many cellular functions. Cell nucleus has been proposed to act as a cellular mechanosensor, and the changes in nuclear shape possibly affect... Cells sense the external environment such as a surface topography and change many cellular functions. Cell nucleus has been proposed to act as a cellular mechanosensor, and the changes in nuclear shape possibly affect the functional regulation of cells. This study demonstrated a large-scale mechanical deformation of the intracellular nucleus using polydimethylsiloxane (PDMS)-based micropillar substrates and investigated the effects of nuclear deformation on migration, proliferation, and differentiation of vascular smooth muscle cells (VSMCs). VSMCs spread completely between the fibronectin-coated pillars, leading to strong deformations of their nuclei resulted in a significant inhibition of the cell migration. The proliferation and smooth muscle differentiation of VSMCs with deformed nuclei were dramatically inhibited on the micropillars. These results indicate that the inhibition of proliferation and VSMC differentiation resulted from deformation of the nucleus with high internal stress, and this type of large-scale nuclear mechanical stress might lead the cells to a “quiescent state”. 展开更多
关键词 CELL BIOMECHANICS MECHANOBIOLOGY nuclear mechanotransduction MICROFABRICATION
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