Neuropeptide receptors of the brain and spinal cord are parts of the pain circuits targeted by analgesic drugs. Some of these receptors have been found in the central nervous system as well as in intracranial vascular...Neuropeptide receptors of the brain and spinal cord are parts of the pain circuits targeted by analgesic drugs. Some of these receptors have been found in the central nervous system as well as in intracranial vascular structures and achieved revival of attention because of their role in acute and chronic pain syndromes. A number of them are of high clinical relevance for e.g. migraine. Others participate in symptoms of rare diseases like amyotrophic lateral sclerosis. Here we will focus on five of the neuropeptide receptors and their non-peptide ligands potentially or already successfully used as PET probes. Opioid receptors and neurotensin receptors are known to mediate analgesic actions. Bradykinin and calcitonin gene-related peptide (CGRP) receptors are known to be involved in the regulation of vascular tone and inflammatory responses, and neurokinin receptors play a role in the occurrence of pain perception in a rather indirect manner. Most experiences as PET tracers have been gathered with opioid receptor ligands and neurokinin receptor ligands. The most innovative fields revealed by the studies summarized in this report are the ligands of κ opioid receptors and CGRP receptors for which a first PET tracer was presented recently.展开更多
目的探讨功能性消化不良(functional dyspepsia,FD)患者血浆中神经肽S受体1(neuropeptide S receptor 1,NPSR1)、降钙素基因相关肽(calcitonin gene related peptide,CGRP)及白介素-6(interleukin-6,IL-6)的表达水平及其临床意义。方法...目的探讨功能性消化不良(functional dyspepsia,FD)患者血浆中神经肽S受体1(neuropeptide S receptor 1,NPSR1)、降钙素基因相关肽(calcitonin gene related peptide,CGRP)及白介素-6(interleukin-6,IL-6)的表达水平及其临床意义。方法选取2012年4月至2015年10月就诊于本院的143例FD患者纳入FD组,其中,上腹痛综合征(epigastric pain syndrome,EPS)70例(EPS组),餐后不适综合征(postprandial distress syndrome,PDS)73例(PDS组)。选取同期于本院体检的健康者80例纳入对照组,采用酶联免疫吸附测定(ELISA)检测所有研究对象血浆中NPSR1、CGRP及IL-6的表达水平,并进行统计学分析。结果 FD组患者最主要的临床症状为消化不良或胀气(82.52%),其次为嗳气(79.72%)、疲乏(76.22%)及腹痛(75.52%)。FD组患者血浆中NPSR1、CGRP、IL-6的表达水平分别为(170.25±16.40)、(117.43±15.58)、(92.75±6.80)pg/ml,对照组分别为(207.10±14.42)、(172.55±8.90)、(65.60±7.35)pg/ml,两组比较差异具有显著性(P<0.05)。PDS组患者血浆中NPSR1、CGRP、IL-6水平分别为(158.55±17.43)、(106.72±14.65)、(88.42±7.15)pg/ml,EPS组分别为(182.00±16.66)、(128.54±16.64)、(97.50±6.75)pg/ml,两组比较差异显著(P<0.05)。结论FD患者血浆中NPSR1、CGRP表达水平下降,而IL-6表达水平升高,提示NPSR1、CGRP及IL-6的表达水平与FD的发生密切相关。展开更多
文摘Neuropeptide receptors of the brain and spinal cord are parts of the pain circuits targeted by analgesic drugs. Some of these receptors have been found in the central nervous system as well as in intracranial vascular structures and achieved revival of attention because of their role in acute and chronic pain syndromes. A number of them are of high clinical relevance for e.g. migraine. Others participate in symptoms of rare diseases like amyotrophic lateral sclerosis. Here we will focus on five of the neuropeptide receptors and their non-peptide ligands potentially or already successfully used as PET probes. Opioid receptors and neurotensin receptors are known to mediate analgesic actions. Bradykinin and calcitonin gene-related peptide (CGRP) receptors are known to be involved in the regulation of vascular tone and inflammatory responses, and neurokinin receptors play a role in the occurrence of pain perception in a rather indirect manner. Most experiences as PET tracers have been gathered with opioid receptor ligands and neurokinin receptor ligands. The most innovative fields revealed by the studies summarized in this report are the ligands of κ opioid receptors and CGRP receptors for which a first PET tracer was presented recently.
