Pregnane X receptor(PXR,NR 112)is a prototypical member of the nuclear receptor superfamily.PXR can be activated by both endobiotics and xenobiotics.As a key xenobiotic receptor,the cellular function of PXR is mostly ...Pregnane X receptor(PXR,NR 112)is a prototypical member of the nuclear receptor superfamily.PXR can be activated by both endobiotics and xenobiotics.As a key xenobiotic receptor,the cellular function of PXR is mostly exerted by its binding to the regulatory gene sequences in a liganddependent manner.Classical downstream target genes of PXR participate in xenobiotic responses,such as detoxification,metabolism and inflammation.Emerging evidence also implicates PXR signaling in the processes of apoptosis,cell cycle arrest,proliferation,angiogenesis and oxidative stress,which are closely related to cancer.Here,we discussed,in addition to the characterization of PXR per se,the biological function and regulatory mechanism of PXR signaling in cancer,and its potential for the targeted prevention and therapeutics.展开更多
基金funded by the National Natural Science Foundation of China(81772972 and 81572703)Guangdong Natural Science Foundation(2015A030313449+4 种基金China)Guangdong Science and Technology Project“Public Research and Capacity Building”Special Project Fund(2014A020212285China)Department of Education,Guangdong Government under the Toptier University Development Scheme for Research and Control of Infectious Diseases(2016026,2015060,and 2015089China).
文摘Pregnane X receptor(PXR,NR 112)is a prototypical member of the nuclear receptor superfamily.PXR can be activated by both endobiotics and xenobiotics.As a key xenobiotic receptor,the cellular function of PXR is mostly exerted by its binding to the regulatory gene sequences in a liganddependent manner.Classical downstream target genes of PXR participate in xenobiotic responses,such as detoxification,metabolism and inflammation.Emerging evidence also implicates PXR signaling in the processes of apoptosis,cell cycle arrest,proliferation,angiogenesis and oxidative stress,which are closely related to cancer.Here,we discussed,in addition to the characterization of PXR per se,the biological function and regulatory mechanism of PXR signaling in cancer,and its potential for the targeted prevention and therapeutics.
