2006年9月，Stroke发表了由美国国立神经疾病和卒中研究所（National Institute for Neurological Disorders and Stroke，NINDS）与加拿大卒中网（Canadian Stroke Network,CSN）联合颁布的血管性认知障碍（vascular cognitive impairm...2006年9月，Stroke发表了由美国国立神经疾病和卒中研究所（National Institute for Neurological Disorders and Stroke，NINDS）与加拿大卒中网（Canadian Stroke Network,CSN）联合颁布的血管性认知障碍（vascular cognitive impairment，VCI）统一标准。该标准由著名卒中学家Hachinski教授牵头撰写。展开更多
Micro RNA-124（mi R-124） is abundantly expressed in neurons in the mammalian central nervous system, and plays critical roles in the regulation of gene expression during embryonic neurogenesis and postnatal neural di...Micro RNA-124（mi R-124） is abundantly expressed in neurons in the mammalian central nervous system, and plays critical roles in the regulation of gene expression during embryonic neurogenesis and postnatal neural differentiation. However, the expression profile of mi R-124 after spinal cord injury and the underlying regulatory mechanisms are not well understood. In the present study, we examined the expression of mi R-124 in mouse brain and spinal cord after spinal cord injury using in situ hybridization. Furthermore, the expression of mi R-124 was examined with quantitative RT-PCR at 1, 3 and 7 days after spinal cord injury. The mi R-124 expression in neurons at the site of injury was evaluated by in situ hybridization combined with Neu N immunohistochemical staining. The mi R-124 was mainly expressed in neurons throughout the brain and spinal cord. The expression of mi R-124 in neurons significantly decreased within 7 days after spinal cord injury. Some of the neurons in the peri-lesion area were Neu N＋/mi R-124-. Moreover, the neurons distal to the peri-lesion site were Neu N＋/mi R-124＋. These findings indicate that mi R-124 expression in neurons is reduced after spinal cord injury, and may reflect the severity of spinal cord injury.展开更多
Endovascular treatment of cerebral aneurysm continues to evolve with the development of new technologies.This review provides an overview of the recent major innovations in the neurointerventional space in recent years.
文摘2006年9月，Stroke发表了由美国国立神经疾病和卒中研究所（National Institute for Neurological Disorders and Stroke，NINDS）与加拿大卒中网（Canadian Stroke Network,CSN）联合颁布的血管性认知障碍（vascular cognitive impairment，VCI）统一标准。该标准由著名卒中学家Hachinski教授牵头撰写。
基金supported by the National Natural Science Foundation of China,No.81371364
文摘Micro RNA-124（mi R-124） is abundantly expressed in neurons in the mammalian central nervous system, and plays critical roles in the regulation of gene expression during embryonic neurogenesis and postnatal neural differentiation. However, the expression profile of mi R-124 after spinal cord injury and the underlying regulatory mechanisms are not well understood. In the present study, we examined the expression of mi R-124 in mouse brain and spinal cord after spinal cord injury using in situ hybridization. Furthermore, the expression of mi R-124 was examined with quantitative RT-PCR at 1, 3 and 7 days after spinal cord injury. The mi R-124 expression in neurons at the site of injury was evaluated by in situ hybridization combined with Neu N immunohistochemical staining. The mi R-124 was mainly expressed in neurons throughout the brain and spinal cord. The expression of mi R-124 in neurons significantly decreased within 7 days after spinal cord injury. Some of the neurons in the peri-lesion area were Neu N＋/mi R-124-. Moreover, the neurons distal to the peri-lesion site were Neu N＋/mi R-124＋. These findings indicate that mi R-124 expression in neurons is reduced after spinal cord injury, and may reflect the severity of spinal cord injury.
文摘Endovascular treatment of cerebral aneurysm continues to evolve with the development of new technologies.This review provides an overview of the recent major innovations in the neurointerventional space in recent years.
