Antimicrobial resistance is an urgent global health challenge in human and veterinary medicine. Wild animals are not directly exposed to clinically relevant antibiotics; however, antibacterial resistance in wild anima...Antimicrobial resistance is an urgent global health challenge in human and veterinary medicine. Wild animals are not directly exposed to clinically relevant antibiotics; however, antibacterial resistance in wild animals has been increasingly reported worldwide in parallel to the situation in human and veterinary medicine. This underlies the complexity of bacterial resistance in wild animals and the possible interspecies transmission between humans, domestic animals, the environment, and wildlife. This review summarizes the current data on expanded- spectrum 13-1actamase （ESBL）, AmpC IB-lactamase, carbapenemase, and colistin resistance genes in Enterobacteriaceae isolates of wildlife origin. The aim of this review is to better understand the important role of wild animals as reservoirs and vectors in the global dissemination of crucial clinical antibacterial resistance. In this regard, continued surveillance is urgently needed worldwide.展开更多
He and his colleagues[1]reported identification of the mobile resistance genes tet(X3)and tet(X4)on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated in China recently published in Nature Microbiol...He and his colleagues[1]reported identification of the mobile resistance genes tet(X3)and tet(X4)on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated in China recently published in Nature Microbiology.They noted that both tet(X3)and tet(X4)can confer resistance to tigecycline and the newly FDA-approved eravacycline and omadacyclin,which are last-resort antibiotics used to treat multi-drug-resistant(MDR)bacterial infections.Our previous report[2]revealed that live poultry market(LPM)is a huge antibiotic resistance gene(ARG)reservoir,including the mobile colistin resistance(mcr)genes,mcr-1,mcr-3,mcr-4 and mcr-5.Large-scale metagenomic data screening showed that tigecycline resistance gene tet(X3)was widespread in poultry faecal samples collected from China LPMs,whereas it has not been detected in human(n=2019)gut microbiomes[3],which suggested that tet(X3)is previously confined to animal guts or animal-derived bacteria.展开更多
目的评价免疫层析法NG-Test CARBA 5筛查碳青霉烯酶分型KPC、NDM、VIM、IMP和OXA48筛查价值。方法计算机检索PubMed(2008.01-2020.12)数据库、ISI Web of Knowledge(2008.01-2020.12)数据库、中文期刊全文数据库(2008.01-2020.12)、中...目的评价免疫层析法NG-Test CARBA 5筛查碳青霉烯酶分型KPC、NDM、VIM、IMP和OXA48筛查价值。方法计算机检索PubMed(2008.01-2020.12)数据库、ISI Web of Knowledge(2008.01-2020.12)数据库、中文期刊全文数据库(2008.01-2020.12)、中文科技期刊数据库(2008.01-2020.12)、万方数据库(2008.01-2020.12),利用手工检索,2名评价员严格依据纳入排除标准收集NGTest CARBA 5筛查碳青霉烯酶分型的试验。依据QUADAS质量评价标准评价纳入研究的质量,后用Meta-Disc软件对数据进行Meta分析。结果最后纳入8个研究文献,一共纳入1634例菌株。Meta分析结果显示:NG-Test CARBA 5筛查碳青霉烯酶,包含KPC、NDM、VIM、IMP、OXA48合并敏感性和特异性分别为99.7%和100%、98.6%和100%、97.6%和100%、92.6%和100%、100%和99.8%。结论NG-Test CARBA 5筛查KPC、NDM、VIM、IMP、OXA485种碳青霉烯酶具有高敏感性和特异性,适用于临床。展开更多
STUDIES of radiation chemistry on methionine (Met) were very active in previous years because of its actions of radioprotection to biological systems by quenching·OH radicals. On the other hand, people have paid ...STUDIES of radiation chemistry on methionine (Met) were very active in previous years because of its actions of radioprotection to biological systems by quenching·OH radicals. On the other hand, people have paid more and more attention to the researches on the phosphorylation of the biological polymolecules. It is wall known that phosphate ester is regarded as the deposi-展开更多
基金partially supported by grants from the National Key Basic Research Program of China(2013CB127200)the National Natural Science Foundation of China(81661138002)
文摘Antimicrobial resistance is an urgent global health challenge in human and veterinary medicine. Wild animals are not directly exposed to clinically relevant antibiotics; however, antibacterial resistance in wild animals has been increasingly reported worldwide in parallel to the situation in human and veterinary medicine. This underlies the complexity of bacterial resistance in wild animals and the possible interspecies transmission between humans, domestic animals, the environment, and wildlife. This review summarizes the current data on expanded- spectrum 13-1actamase （ESBL）, AmpC IB-lactamase, carbapenemase, and colistin resistance genes in Enterobacteriaceae isolates of wildlife origin. The aim of this review is to better understand the important role of wild animals as reservoirs and vectors in the global dissemination of crucial clinical antibacterial resistance. In this regard, continued surveillance is urgently needed worldwide.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB29010000)the External Cooperation Program of CAS(153211KYSB20160001).
文摘He and his colleagues[1]reported identification of the mobile resistance genes tet(X3)and tet(X4)on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated in China recently published in Nature Microbiology.They noted that both tet(X3)and tet(X4)can confer resistance to tigecycline and the newly FDA-approved eravacycline and omadacyclin,which are last-resort antibiotics used to treat multi-drug-resistant(MDR)bacterial infections.Our previous report[2]revealed that live poultry market(LPM)is a huge antibiotic resistance gene(ARG)reservoir,including the mobile colistin resistance(mcr)genes,mcr-1,mcr-3,mcr-4 and mcr-5.Large-scale metagenomic data screening showed that tigecycline resistance gene tet(X3)was widespread in poultry faecal samples collected from China LPMs,whereas it has not been detected in human(n=2019)gut microbiomes[3],which suggested that tet(X3)is previously confined to animal guts or animal-derived bacteria.
文摘STUDIES of radiation chemistry on methionine (Met) were very active in previous years because of its actions of radioprotection to biological systems by quenching·OH radicals. On the other hand, people have paid more and more attention to the researches on the phosphorylation of the biological polymolecules. It is wall known that phosphate ester is regarded as the deposi-
