Background：Repetitive transcranial magnetic stimulation （rTMS） and event-related potentials （ERPs） are a noninvasive technique that widely used in neurophysiological field.Although rTMS has shown clinical utility...Background：Repetitive transcranial magnetic stimulation （rTMS） and event-related potentials （ERPs） are a noninvasive technique that widely used in neurophysiological field.Although rTMS has shown clinical utility for a number of neurological conditions,Recently,there was little understanding of the the efficacy ofrYMS on Schizophrenia（SZ） and the change of ERP between before and after rTMS treatment.The objective of this study was to investigate the characteristics of N400,mismatch negativity （MMN）,and P300 before and after treatment with rTMS in SZ.Methods：One hundred and twenty-seven SZ patients hospitalized in Shanghai Mental Health Center from March 2015 to July 2017,divided into two groups （85 patients were recruited as rTMS group and 42 were recruited as sham rTMS [ShrTMS] group） and 76 normal controls （NCs） who were the staff and refresher staff in our hospital were recruited at the same time.A Chinese-made rTMS and a Runjie W J-1 ERPs instrument were used in the present experiment.N400 was elicited by congruent and noncongruent Chinese idioms.After rTMS treatment,N400,P300,and MMN characteristics were compared with those before treatment and NC group.Results：Compared with NC,the SZ patients exhibited delays in N400,P300,and MMN latency and decreased N400,P300,and MMN amplitudes in their frontal area （P 〈 0.05）.After 25 rTMS treatments,N400 amplitudes in the frontal area （elicited by idioms with same phonic and different shape and meaning and with different phonic,shape,and meaning） were increased in the SZ patients （P 〈 0.05）.However,there was no significant change in N400 before and after treatment with ShrTMS in SZ patients （P 〉 0.05）.Amplitudes for MMN and target P300 also increased in SZ patients after rTMS treatment （P 〈 0.05）.Conclusions：Based on our preliminary findings,we believe that the combined usage of N400,MMN,and P300 could be a valuable index and an electrophysiological reference in evaluating the effects ofrTMS treatment in SZ pat展开更多
基金This study was supported by a grant from the National Natural Science Foundation of China （No. 81471357）.
文摘Background：Repetitive transcranial magnetic stimulation （rTMS） and event-related potentials （ERPs） are a noninvasive technique that widely used in neurophysiological field.Although rTMS has shown clinical utility for a number of neurological conditions,Recently,there was little understanding of the the efficacy ofrYMS on Schizophrenia（SZ） and the change of ERP between before and after rTMS treatment.The objective of this study was to investigate the characteristics of N400,mismatch negativity （MMN）,and P300 before and after treatment with rTMS in SZ.Methods：One hundred and twenty-seven SZ patients hospitalized in Shanghai Mental Health Center from March 2015 to July 2017,divided into two groups （85 patients were recruited as rTMS group and 42 were recruited as sham rTMS [ShrTMS] group） and 76 normal controls （NCs） who were the staff and refresher staff in our hospital were recruited at the same time.A Chinese-made rTMS and a Runjie W J-1 ERPs instrument were used in the present experiment.N400 was elicited by congruent and noncongruent Chinese idioms.After rTMS treatment,N400,P300,and MMN characteristics were compared with those before treatment and NC group.Results：Compared with NC,the SZ patients exhibited delays in N400,P300,and MMN latency and decreased N400,P300,and MMN amplitudes in their frontal area （P 〈 0.05）.After 25 rTMS treatments,N400 amplitudes in the frontal area （elicited by idioms with same phonic and different shape and meaning and with different phonic,shape,and meaning） were increased in the SZ patients （P 〈 0.05）.However,there was no significant change in N400 before and after treatment with ShrTMS in SZ patients （P 〉 0.05）.Amplitudes for MMN and target P300 also increased in SZ patients after rTMS treatment （P 〈 0.05）.Conclusions：Based on our preliminary findings,we believe that the combined usage of N400,MMN,and P300 could be a valuable index and an electrophysiological reference in evaluating the effects ofrTMS treatment in SZ pat
文摘一、概述
人类脑电活动研究的发展,在20世纪中经过了三个主要阶段.第一阶段自七十年前Berger 发现了人类脑电波并发表了他的论文开始.第二阶段从1949年Dawson的工作开始,他记录并分析了人的脑诱发电位.第三阶段始于1964年,研究者开始应用可供利用的各种先进技术工具及方法,创立了事件相关电位(Event related potentials,下简称ERP)中的关联性负变(CNV).这些进步及其临床应用开始了脑电研究的新的局面,使脑电活动能够与正常或异常行为联系起来进行观察.
