Objective To investigate the effect of acute myocardium ischemic on heart function of pregnancy rat. Methods 13 female SD rats and 6 early pregnancy rats were divided into normal group, unpregnant group with acute myo...Objective To investigate the effect of acute myocardium ischemic on heart function of pregnancy rat. Methods 13 female SD rats and 6 early pregnancy rats were divided into normal group, unpregnant group with acute myocardial infarction and early pregnant group with acute myocardial infarction. The anterior branch of the left coronary artery was ligated. 3 weeks later, Image 1.31 software was used to measure areas of myocardial infarction, and to evaluate hemodynamics of heart with powerLAB4.12, and cardiac tissues were stained with Massion. Results Compared with unpregnant group with acute myocardial infarction , the early pregnant group with acute myocardial infarction had less myocardial infarction area (28.86% vs. 36.8%),and had a higher left ventricle end systolic pressure, ±dp/dt _ max , and lower left ventricle end diastolic pressure. Massion stain showed the amount of collagen of the lesion was less in the early pregnant group with acute myocardial infarction than that in unpregnant group. Conclusion The early pregnant group with acute myocardial infarction had better heart contractive and diastolic function .展开更多
文摘Objective To investigate the effect of acute myocardium ischemic on heart function of pregnancy rat. Methods 13 female SD rats and 6 early pregnancy rats were divided into normal group, unpregnant group with acute myocardial infarction and early pregnant group with acute myocardial infarction. The anterior branch of the left coronary artery was ligated. 3 weeks later, Image 1.31 software was used to measure areas of myocardial infarction, and to evaluate hemodynamics of heart with powerLAB4.12, and cardiac tissues were stained with Massion. Results Compared with unpregnant group with acute myocardial infarction , the early pregnant group with acute myocardial infarction had less myocardial infarction area (28.86% vs. 36.8%),and had a higher left ventricle end systolic pressure, ±dp/dt _ max , and lower left ventricle end diastolic pressure. Massion stain showed the amount of collagen of the lesion was less in the early pregnant group with acute myocardial infarction than that in unpregnant group. Conclusion The early pregnant group with acute myocardial infarction had better heart contractive and diastolic function .
文摘目的应用速度向量成像(velocity vector imaging,VVI)技术分析梗死心肌和缺血心肌纵向运动特点,评价VVI技术测定心肌运动功能的价值。方法选择2007年12月-2008年1月行超声心动图检查者,其中梗死组6例,均为急性前壁心肌梗死;缺血组9例,前降支狭窄>70%,有心绞痛症状;正常对照组16例。应用Sequoia512超声成像仪在VVI技术模式下采集心尖左心室长轴和左心室两腔心切面动态图像。采用Syngo US workplace工作站对图像进行脱机分析,定量分析左心室前壁和前间隔梗死节段、缺血节段和正常节段的纵向速度、位移、应变和应变率。结果正常对照组左心室前壁和前间隔纵向收缩期峰值速度(Vs)和峰值位移(D)自基底段向心尖段递减,差异有统计学意义(P<0.05);峰值应变(S)和收缩期峰值应变率(SRs)在基底段、中间段和心尖段上差异无统计学意义(P>0.05)。梗死组心肌各项指标均较正常对照组和缺血组减低,S和SRs减低更明显,差异均有统计学意义(P<0.05)。缺血组心肌仅前壁基底段和中间段的S显著低于正常对照组(P<0.05)。以任意节段S<—6.94%作为诊断急性心肌梗死的临界值,敏感度和特异度均为100%;以任意节段SRs<—0.81%作为诊断急性心肌梗死的临界值,敏感度为100%,特异度为80%;以任意节段SRs<—0.46%作为诊断急性心肌梗死的临界值,其敏感度为83%,特异度为100%。结论VVI技术具有准确定量评价急性心肌梗死的临床应用价值,尤其是应变和应变率能提供更多有价值的信息。
