This study was aimed at evaluating the iron status of multiple blood transfused sickle cell anaemia (SCA) patients in Benin City, Nigeria. A total of 86 subjects participated in the study, comprising of 30 multiple tr...This study was aimed at evaluating the iron status of multiple blood transfused sickle cell anaemia (SCA) patients in Benin City, Nigeria. A total of 86 subjects participated in the study, comprising of 30 multiple transfused SCA subjects, 30 of rarely transfused SCA subjects and 26 of age and sex matched healthy control subjects. Serum ferritin was determined by enzyme linked immuno sorbent assay technique. Serum iron and Total iron binding capacity was determined by spectrophometric method. The mean serum ferritin concentration was elevated in the sickle cell anaemia patients whose multiple transfusions (MT) are more than those who were rarely transfused (RT) as compared with the control groups (p < 0.001). There was a positive correlation between the serum ferritin and the number of units of blood transfused (r = 0.719, p = 0.000). This study revealed that a high level of serum ferritin, percentage transferrin saturation and a reduction in total iron binding capacity were observed in sickle cell anaemia patients who received ≥3 units of packed cells in one year.展开更多
目的分析输血次数与多次输血血液病患者输注效果的关系。方法选取2020年5月—2023年7月菏泽市立医院收治的600例多次输血(≥2次)的血液病患者作为研究对象,根据输血次数不同将患者分为A组225例(2~3次)、B组195例(4~6次)及C组180例(≥7次...目的分析输血次数与多次输血血液病患者输注效果的关系。方法选取2020年5月—2023年7月菏泽市立医院收治的600例多次输血(≥2次)的血液病患者作为研究对象,根据输血次数不同将患者分为A组225例(2~3次)、B组195例(4~6次)及C组180例(≥7次)。比较3组患者血小板抗体阳性率;比较血小板抗体阳性与阴性患者输注血小板后1、24 h校正血小板计数增加值(CCI)及输注有效率。结果600例患者中共226例患者检测血小板抗体阳性,阳性率为37.67%,其中C组血小板抗体阳性率高于A、B组(P<0.01)。血小板抗体阳性者输注后1、24 h CCI及输注有效率均低于血小板阴性患者(P<0.01)。结论输血次数越多,血液病患者血小板抗体阳性率越高,而血小板抗体阳性患者的血小板输注效果较差,而血小板抗体筛查能有效提高输血效果。展开更多
文摘This study was aimed at evaluating the iron status of multiple blood transfused sickle cell anaemia (SCA) patients in Benin City, Nigeria. A total of 86 subjects participated in the study, comprising of 30 multiple transfused SCA subjects, 30 of rarely transfused SCA subjects and 26 of age and sex matched healthy control subjects. Serum ferritin was determined by enzyme linked immuno sorbent assay technique. Serum iron and Total iron binding capacity was determined by spectrophometric method. The mean serum ferritin concentration was elevated in the sickle cell anaemia patients whose multiple transfusions (MT) are more than those who were rarely transfused (RT) as compared with the control groups (p < 0.001). There was a positive correlation between the serum ferritin and the number of units of blood transfused (r = 0.719, p = 0.000). This study revealed that a high level of serum ferritin, percentage transferrin saturation and a reduction in total iron binding capacity were observed in sickle cell anaemia patients who received ≥3 units of packed cells in one year.
文摘目的分析输血次数与多次输血血液病患者输注效果的关系。方法选取2020年5月—2023年7月菏泽市立医院收治的600例多次输血(≥2次)的血液病患者作为研究对象,根据输血次数不同将患者分为A组225例(2~3次)、B组195例(4~6次)及C组180例(≥7次)。比较3组患者血小板抗体阳性率;比较血小板抗体阳性与阴性患者输注血小板后1、24 h校正血小板计数增加值(CCI)及输注有效率。结果600例患者中共226例患者检测血小板抗体阳性,阳性率为37.67%,其中C组血小板抗体阳性率高于A、B组(P<0.01)。血小板抗体阳性者输注后1、24 h CCI及输注有效率均低于血小板阴性患者(P<0.01)。结论输血次数越多,血液病患者血小板抗体阳性率越高,而血小板抗体阳性患者的血小板输注效果较差,而血小板抗体筛查能有效提高输血效果。
