目的探讨与重症急性胰腺炎(SAP)死亡相关的高危因素。方法回顾性分析2001年1月至2005年10月收治的141例 SAP 患者的临床资料。将患者分为死亡组和生存组,对可能影响 SAP 预后的15个因素采用 Logistic 回归分析。结果 141例 SAP 患者中死...目的探讨与重症急性胰腺炎(SAP)死亡相关的高危因素。方法回顾性分析2001年1月至2005年10月收治的141例 SAP 患者的临床资料。将患者分为死亡组和生存组,对可能影响 SAP 预后的15个因素采用 Logistic 回归分析。结果 141例 SAP 患者中死亡34例(24.1%)。死亡组患者在年龄、体重指数、住院时间、APACHEⅡ评分和并发多器官功能障碍综合征(MODS)、腹腔室隔综合征(ACS)等方面与生存组相比差异有统计学意义(P<0.05)。多因素分析显示,MODS(OR=67.358,P<0.01)、APACHEⅡ评分(OR=9.716,P<0.01)和 ACS(OR=5.775,P<0.05)是早期影响 SAP 预后的独立危险因素;胰腺感染(OR=9.652,P<0.01)、MODS(OR=5.212,P<0.05)和腹腔出血(OR=4.707,P<0.05)则是后期影响 SAP 预后的独立危险因素。结论 SAP 早期死亡的主要原因是 MODS,特别是呼吸功能障碍和肾功能障碍,而后期死亡的主要原因是感染、MODS 和腹腔出血。对高危因素进行早期预防和及时处理是降低 SAP 病死率的关键。展开更多
BACKGROUND We studied the protective effects of Qingyi decoction(QYD)(a Traditional Chinese Medicine)against severe acute pancreatitis(SAP)-induced myocardial infarction(MI).AIM To study the function and mechanism of ...BACKGROUND We studied the protective effects of Qingyi decoction(QYD)(a Traditional Chinese Medicine)against severe acute pancreatitis(SAP)-induced myocardial infarction(MI).AIM To study the function and mechanism of QYD in the treatment of myocardial injuries induced by SAP.METHODS Ultrasonic cardiography,hematoxylin and eosin staining,immunohistochemistry,qRT-PCR,western blot,enzyme-linked immunosorbent assays,and apoptosis staining techniques were used to determine the effects of QYD following SAP-induced MI in Sprague-Dawley rats.RESULTS Our SAP model showed severe myocardial histological abnormalities and marked differences in the symptoms,mortality rate,and ultrasonic cardiography outputs among the different groups compared to the control.The expression of serum cytokines[interleukin(IL)-1?,IL-6,IL-8,IL-12,amyloidβ,and tumor necrosis factor-α]were significantly higher in the SAP versus QYD treated group(P<0.05 for all).STIM1 and Orai1 expression in myocardial tissue extracts were significantly decreased post QYD gavage(P<0.001).There was no significant histological difference between the 2-aminoethyl diphenylborinate inhibitor and QYD groups.The SAP group had a significantly higher apoptosis index score compared to the QYD group(P<0.001).CONCLUSION QYD conferred cardio-protection against SAP-induced MI by regulating myocardial-associated protein expression(STIM1 and Orai1).展开更多
文摘目的探讨与重症急性胰腺炎(SAP)死亡相关的高危因素。方法回顾性分析2001年1月至2005年10月收治的141例 SAP 患者的临床资料。将患者分为死亡组和生存组,对可能影响 SAP 预后的15个因素采用 Logistic 回归分析。结果 141例 SAP 患者中死亡34例(24.1%)。死亡组患者在年龄、体重指数、住院时间、APACHEⅡ评分和并发多器官功能障碍综合征(MODS)、腹腔室隔综合征(ACS)等方面与生存组相比差异有统计学意义(P<0.05)。多因素分析显示,MODS(OR=67.358,P<0.01)、APACHEⅡ评分(OR=9.716,P<0.01)和 ACS(OR=5.775,P<0.05)是早期影响 SAP 预后的独立危险因素;胰腺感染(OR=9.652,P<0.01)、MODS(OR=5.212,P<0.05)和腹腔出血(OR=4.707,P<0.05)则是后期影响 SAP 预后的独立危险因素。结论 SAP 早期死亡的主要原因是 MODS,特别是呼吸功能障碍和肾功能障碍,而后期死亡的主要原因是感染、MODS 和腹腔出血。对高危因素进行早期预防和及时处理是降低 SAP 病死率的关键。
基金the National Natural Science Foundation of China,No,81573751.
文摘BACKGROUND We studied the protective effects of Qingyi decoction(QYD)(a Traditional Chinese Medicine)against severe acute pancreatitis(SAP)-induced myocardial infarction(MI).AIM To study the function and mechanism of QYD in the treatment of myocardial injuries induced by SAP.METHODS Ultrasonic cardiography,hematoxylin and eosin staining,immunohistochemistry,qRT-PCR,western blot,enzyme-linked immunosorbent assays,and apoptosis staining techniques were used to determine the effects of QYD following SAP-induced MI in Sprague-Dawley rats.RESULTS Our SAP model showed severe myocardial histological abnormalities and marked differences in the symptoms,mortality rate,and ultrasonic cardiography outputs among the different groups compared to the control.The expression of serum cytokines[interleukin(IL)-1?,IL-6,IL-8,IL-12,amyloidβ,and tumor necrosis factor-α]were significantly higher in the SAP versus QYD treated group(P<0.05 for all).STIM1 and Orai1 expression in myocardial tissue extracts were significantly decreased post QYD gavage(P<0.001).There was no significant histological difference between the 2-aminoethyl diphenylborinate inhibitor and QYD groups.The SAP group had a significantly higher apoptosis index score compared to the QYD group(P<0.001).CONCLUSION QYD conferred cardio-protection against SAP-induced MI by regulating myocardial-associated protein expression(STIM1 and Orai1).
