Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Severa...Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations.展开更多
The Indian power system underwent two separate massive blackouts on 30th and 31st of July 2012.These blackouts exposed a series of inherent problems underlying the power system of India,such as its generation planning...The Indian power system underwent two separate massive blackouts on 30th and 31st of July 2012.These blackouts exposed a series of inherent problems underlying the power system of India,such as its generation planning,transmission planning,grid infrastructure,management systems,primary energy resources,environmental constraints,electricity market,and information technology,which together aggravate the massive blackouts.These factors which affect the adequacy and security of the power supply in a similar manner as the transmission congestion of physical grids does,can be called by a generic term as generalized congestion.Competitive manipulations and“game-playing”between various interested parties further intensifies these congestions.Here,from the perspective of generalized congestions,the paper reflects the inevitability of India’s massive blackouts,discusses occasional effects of trigger events,inherent evolution law of blackouts and the enlightenment on power industry in China,and explores risk control measures to defend blackouts in China.The positive role of strong smart grid in insuring energy and environment security is highlighted.展开更多
Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin(MSTN),but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming.Moreover,insurmountabl...Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin(MSTN),but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming.Moreover,insurmountable challenges with congenital lameness and a dearth of data about the impacts of feed conversion,reproduction,and meat quality in MSTN-edited pigs have also currently blocked progress.Here,in a largest-to-date evaluation of multiple MSTN-edited pig populations,we demonstrated a practical alternative edit-site-based solution that overcomes the major production obstacle of hindlimb weakness.We also provide long-term and multidomain datasets for multiple breeds that illustrate how MSTN-editing can sustainably increase the yields of breed-specific lean meat and the levels of desirable lipids without deleteriously affecting feed-conversion rates or litter size.Apart from establishing a new benchmark for the data scale and quality of genome-edited animal production,our study specifically illustrates how gene-editing site selection profoundly impacts the phenotypic outcomes in diverse genetic back-grounds.展开更多
Multidomain pseudospectral approximations to nonlinear convection-diffusion equations are considered. The schemes are formulated with the Legendre-Galerkin method but the nonlinear term is collocated at the Legendre/C...Multidomain pseudospectral approximations to nonlinear convection-diffusion equations are considered. The schemes are formulated with the Legendre-Galerkin method but the nonlinear term is collocated at the Legendre/Chebyshev-Gauss-Lobatto points inside each subinterval. Appropriate base functions are introduced so that the matrix of the system is sparse, and the method can be implemented efficiently and in parallel. The stability and the optimal rate of convergence of the methods are proved. Numerical results are given for both the single domain and the multidomain methods to make a comparison.展开更多
Many enzymes which catalyze the conversion of large substrates are made of several structural domains belonging to the same polypeptide chain. Transfer RNA (tRNA), one of the substrates of the multidomain aminoacyl-tR...Many enzymes which catalyze the conversion of large substrates are made of several structural domains belonging to the same polypeptide chain. Transfer RNA (tRNA), one of the substrates of the multidomain aminoacyl-tRNA synthetases (aaRS), is an L-shaped molecule whose size in one dimension is similar to that of its cognate aaRS. Crystallographic structures of aaRS/tRNA complexes show that these enzymes use several of their structural domains to interact with their cognate tRNA. This mini review discusses first some aspects of the evolution and of the flexibility of the pentadomain bacterial glutamyl-tRNA synthetase (GluRS) revealed by kinetic and interaction studies of complementary truncated forms, and then illustrates how stable analogues of aminoacyl-AMP intermediates have been used to probe conformational changes in the active sites of Escherichia coli GluRS and of the nondiscriminating aspartyl-tRNA synthetase (ND-AspRS) of Pseudomonas aeruginosa.展开更多
In order to intensify market competition, manufacturing enterprises must improve their product innovation capability. It is difficult to integrate the system modeling, simulation and collaborative process management i...In order to intensify market competition, manufacturing enterprises must improve their product innovation capability. It is difficult to integrate the system modeling, simulation and collaborative process management in complex product development. A collaborative platform for complex product development based on multi-domain unified modeling and simulation is proposed in this paper. The architecture of the platform is firstly stated. The idea and realization of three key technologies, i.e. multi-domain modeling and simulation for complex product, knowledge management for product design and simulation, multi-domain collaborative mechanism, are emphasized. Finally, an industry case is given. The demonstration of the system shows that integration architecture is the effective infrastructure for multi-domain collaborative product development.展开更多
Type III antifreeze proteins(AFPIIIs)are a group of small globular proteins found in some polar fishes to protect them against freezing damage.Transgenic expression of AFPs has been shown to confer cold tolerance to c...Type III antifreeze proteins(AFPIIIs)are a group of small globular proteins found in some polar fishes to protect them against freezing damage.Transgenic expression of AFPs has been shown to confer cold tolerance to commercially important plants and animals.We have previously isolated multiple AFPIII genes in the Antarctic eelpout(Lycodichthys dearborni)that encode larger AFPIII isoforms with up to 12 of the conventional domains.Here we have introduced the fish AFPIII genes that encode for the monomer(ld1),dimer(ld2),trimer(ld3)and tetramer(ld4)AFPIII isoforms in tobacco plants.Pot-grown 4-week-old transgenic tobacco plants were exposed to cold stress at 4◦C for 30 days and the results show that ld1,ld2,ld3 and ld4 transgenic plants present relatively lower electrolyte leakage and lower content of malondialdehyde(MDA),but accumulated higher content of proline when compared to control plants.This indicates considerable improved membrane integrity under low temperature stress and improvement of the plant cold resistance.The plants transformed with the AFPIII tetramer-and trimer-domains demonstrated a higher cold-tolerant levels when compared with plants transformed with the dimer-and monomer AFPIII domains.Our study further supports that fish AFPIIIs,especially the multidomain proteins,protect cells from non-freezing hypothermic stresses,apart from there well-known function as ice inhibitors molecules at freezing temperature.展开更多
First-break picking is the key step in seismic data processing for surveying undulate surfaces, and directly infl uences the precision of near-surface modeling and effects of static corrections. The current first-brea...First-break picking is the key step in seismic data processing for surveying undulate surfaces, and directly infl uences the precision of near-surface modeling and effects of static corrections. The current first-break auto-picking methods may fail when the signalto-noise ratio（SNR） is low for seismic data in the undulate area, and require labor and time intensive manual picking. This study develops an improved super-virtual interferometry（SVI） method that combines multichannel and multidomain quality control（MMQC） techniques to achieve auto-picked first breaks. The improved SVI method extends the SVI application to enhance the SNR for near-surface scattered waves for the first time, which allows for the SVI method to adapt to first breaks with complex raypaths by linear combination of refractions and near-surface scattered waves. Methods of inverse and multidomain interferometry are developed to effectively enhance the virtual records extracted by the SVI method. The deconvolution filter for waveforms is used to increase resolution and reduce false picks, while the MMQC technique is designed to auto-correct false picks and increase the stability of auto-picking first breaks. The robust technique developed in this study enables stable processing of large 3D seismic datasets. Higher quality results are obtained using the approach presented in this paper to actual field data from the mountain areas in western China, when compared to some commonly used commercial software.展开更多
基金TagedPThis work was supported by the following grants:Instituto de Salud Carlos III and co-funded by FEDER(Grant number PIE15/00013)SAF2016-75508-R from the Spanish Ministry of Education and Science(MEC)+2 种基金CB16/10/00435(CIBERFES)PROMETEOII2014/056 from Conselleria,de Sanitat de la Generalitat Valenciana and EU Funded CM1001 and FRAILOMICHEALTH.2012.2.1.1-2ADVANTAGE-724099 Join Action(HP-JA)3rd EU Health Programme and DIALBFRAIL-LATAM(825546 H2020-SC1-BHC).
文摘Dementia is one of the greatest global challenges for health and social care in the 21st century.Alzheimer’s disease(AD),the most common type of dementia,is by no means an inevitable consequence of growing old.Several lifestyle factors may increase,or reduce,an individual’s risk of developing AD.Much has been written over the ages about the benefits of exercise and physical activity.Among the risk factors associated with AD is a low level of physical activity.The relationship between physical and mental health was established several years ago.In this review,we discuss the role of exercise(aerobic and resistance)training as a therapeutic strategy for the treatment and prevention of AD.Older adults who exercise are more likely to maintain cognition.We address the main protective mechanism on brain function modulated by physical exercise by examining both human and animal studies.We will pay especial attention to the potential role of exercise in the modulation of amyloid b turnover,inflammation,synthesis and release of neurotrophins,and improvements in cerebral blood flow.Promoting changes in lifestyle in presymptomatic and predementia disease stages may have the potential for delaying one-third of dementias worldwide.Multimodal interventions that include the adoption of an active lifestyle should be recommended for older populations.
文摘The Indian power system underwent two separate massive blackouts on 30th and 31st of July 2012.These blackouts exposed a series of inherent problems underlying the power system of India,such as its generation planning,transmission planning,grid infrastructure,management systems,primary energy resources,environmental constraints,electricity market,and information technology,which together aggravate the massive blackouts.These factors which affect the adequacy and security of the power supply in a similar manner as the transmission congestion of physical grids does,can be called by a generic term as generalized congestion.Competitive manipulations and“game-playing”between various interested parties further intensifies these congestions.Here,from the perspective of generalized congestions,the paper reflects the inevitability of India’s massive blackouts,discusses occasional effects of trigger events,inherent evolution law of blackouts and the enlightenment on power industry in China,and explores risk control measures to defend blackouts in China.The positive role of strong smart grid in insuring energy and environment security is highlighted.
基金the National Major Transgenic Breeding Project(2008ZX08006-003,2011ZX08006-003,2013ZX08006-003,2014ZX08006-003,and 2016ZX08006-001)the Na-tional Key Basic Research Development Plan(2015CB943100)+1 种基金the Key Projects of the National Natural Science Foundation of China(30830080 and 31330074)China Postdoctoral Foundation Project(2018M631648)。
文摘Beef and mutton production has been aided by breeding to integrate allelic diversity for myostatin(MSTN),but a lack of diversity in the MSTN germplasm has limited similar advances in pig farming.Moreover,insurmountable challenges with congenital lameness and a dearth of data about the impacts of feed conversion,reproduction,and meat quality in MSTN-edited pigs have also currently blocked progress.Here,in a largest-to-date evaluation of multiple MSTN-edited pig populations,we demonstrated a practical alternative edit-site-based solution that overcomes the major production obstacle of hindlimb weakness.We also provide long-term and multidomain datasets for multiple breeds that illustrate how MSTN-editing can sustainably increase the yields of breed-specific lean meat and the levels of desirable lipids without deleteriously affecting feed-conversion rates or litter size.Apart from establishing a new benchmark for the data scale and quality of genome-edited animal production,our study specifically illustrates how gene-editing site selection profoundly impacts the phenotypic outcomes in diverse genetic back-grounds.
基金supported by the National Natural Science Foundation of China(No.60874039)the Leading Academic Discipline Project of Shanghai Municipal Education Commission(No.J50101)
文摘Multidomain pseudospectral approximations to nonlinear convection-diffusion equations are considered. The schemes are formulated with the Legendre-Galerkin method but the nonlinear term is collocated at the Legendre/Chebyshev-Gauss-Lobatto points inside each subinterval. Appropriate base functions are introduced so that the matrix of the system is sparse, and the method can be implemented efficiently and in parallel. The stability and the optimal rate of convergence of the methods are proved. Numerical results are given for both the single domain and the multidomain methods to make a comparison.
文摘Many enzymes which catalyze the conversion of large substrates are made of several structural domains belonging to the same polypeptide chain. Transfer RNA (tRNA), one of the substrates of the multidomain aminoacyl-tRNA synthetases (aaRS), is an L-shaped molecule whose size in one dimension is similar to that of its cognate aaRS. Crystallographic structures of aaRS/tRNA complexes show that these enzymes use several of their structural domains to interact with their cognate tRNA. This mini review discusses first some aspects of the evolution and of the flexibility of the pentadomain bacterial glutamyl-tRNA synthetase (GluRS) revealed by kinetic and interaction studies of complementary truncated forms, and then illustrates how stable analogues of aminoacyl-AMP intermediates have been used to probe conformational changes in the active sites of Escherichia coli GluRS and of the nondiscriminating aspartyl-tRNA synthetase (ND-AspRS) of Pseudomonas aeruginosa.
基金Supported by the National Natural Science Foundation of China (60736019)the National High Technology Research and Development Program of China (863 Program) (2007AA40603)
文摘In order to intensify market competition, manufacturing enterprises must improve their product innovation capability. It is difficult to integrate the system modeling, simulation and collaborative process management in complex product development. A collaborative platform for complex product development based on multi-domain unified modeling and simulation is proposed in this paper. The architecture of the platform is firstly stated. The idea and realization of three key technologies, i.e. multi-domain modeling and simulation for complex product, knowledge management for product design and simulation, multi-domain collaborative mechanism, are emphasized. Finally, an industry case is given. The demonstration of the system shows that integration architecture is the effective infrastructure for multi-domain collaborative product development.
基金The work is supported by Natural Science Foundation of China[31572611]the National Key Research and Development Program of China[2018YFD0900601]the Major Science Innovation Grant[2017-01-07-00-10-E00060]from the Shanghai Education Committee to L.Chen.
文摘Type III antifreeze proteins(AFPIIIs)are a group of small globular proteins found in some polar fishes to protect them against freezing damage.Transgenic expression of AFPs has been shown to confer cold tolerance to commercially important plants and animals.We have previously isolated multiple AFPIII genes in the Antarctic eelpout(Lycodichthys dearborni)that encode larger AFPIII isoforms with up to 12 of the conventional domains.Here we have introduced the fish AFPIII genes that encode for the monomer(ld1),dimer(ld2),trimer(ld3)and tetramer(ld4)AFPIII isoforms in tobacco plants.Pot-grown 4-week-old transgenic tobacco plants were exposed to cold stress at 4◦C for 30 days and the results show that ld1,ld2,ld3 and ld4 transgenic plants present relatively lower electrolyte leakage and lower content of malondialdehyde(MDA),but accumulated higher content of proline when compared to control plants.This indicates considerable improved membrane integrity under low temperature stress and improvement of the plant cold resistance.The plants transformed with the AFPIII tetramer-and trimer-domains demonstrated a higher cold-tolerant levels when compared with plants transformed with the dimer-and monomer AFPIII domains.Our study further supports that fish AFPIIIs,especially the multidomain proteins,protect cells from non-freezing hypothermic stresses,apart from there well-known function as ice inhibitors molecules at freezing temperature.
基金supported by the National Basic Research Program of China(No.2013CB228602)the National Science and Technology Major Project of China(No.2011ZX05004-003)the National High Tech Research Program of China(No.2013AA064202)
文摘First-break picking is the key step in seismic data processing for surveying undulate surfaces, and directly infl uences the precision of near-surface modeling and effects of static corrections. The current first-break auto-picking methods may fail when the signalto-noise ratio（SNR） is low for seismic data in the undulate area, and require labor and time intensive manual picking. This study develops an improved super-virtual interferometry（SVI） method that combines multichannel and multidomain quality control（MMQC） techniques to achieve auto-picked first breaks. The improved SVI method extends the SVI application to enhance the SNR for near-surface scattered waves for the first time, which allows for the SVI method to adapt to first breaks with complex raypaths by linear combination of refractions and near-surface scattered waves. Methods of inverse and multidomain interferometry are developed to effectively enhance the virtual records extracted by the SVI method. The deconvolution filter for waveforms is used to increase resolution and reduce false picks, while the MMQC technique is designed to auto-correct false picks and increase the stability of auto-picking first breaks. The robust technique developed in this study enables stable processing of large 3D seismic datasets. Higher quality results are obtained using the approach presented in this paper to actual field data from the mountain areas in western China, when compared to some commonly used commercial software.
