Medication during pregnancy is widespread,but there are few reports on its fetal safety.Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multipl...Medication during pregnancy is widespread,but there are few reports on its fetal safety.Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multiple pathways,multiple organs,and multiple targets.Its mechanisms involve direct ways such as oxidative stress,epigenetic modification,and metabolic activation,and it may also be indirectly caused by placental dysfunction.Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming,functional homeostasis changes,and susceptibility to related diseases in offspring by inducing fetal intrauterine exposure to too high or too low levels of maternal-derived glucocorticoids.The organ developmental toxicity and programming alterations caused by medication during pregnancy may also have gender differences and multi-generational genetic effects mediated by abnormal epigenetic modification.Combined with the latest research results of our laboratory,this paper reviews the latest research progress on the developmental toxicity and functional programming alterations of multiple organs in offspring induced by medication during pregnancy,which can provide a theoretical and experimental basis for rational medication during pregnancy and effective prevention and treatment of drug-related multiple fetal-originated diseases.展开更多
Antibiotics are emerging pollutants with pseudo-persistence.However,their reproductive toxicities over generations and underlying mechanisms were seldom explored.In the present study,reproductive effects of erythromyc...Antibiotics are emerging pollutants with pseudo-persistence.However,their reproductive toxicities over generations and underlying mechanisms were seldom explored.In the present study,reproductive effects of erythromycin(ERY)and sulfamethoxazole(SMZ)were studied on Caenorhabditis elegans(C.elegans)with multi-generational exposure from F1 to F4,and their effects in the non-direct exposed offspring of F1 and F4(T4 and T4’)were explored to investigate trans-generational outcomes.At high concentrations,ERY and SMZ inhibited the reproduction and the inhibition decreased with more generations’exposure.At low concentrations,SMZ stimulated reproduction in T4,opposite to its inhibition in F1.Further analysis on ten enzymes and proteins in lipid and glucolipid metabolism showed that ERY commonly inhibited fatty acid synthetase(FAS)in F1 to F4,while ERY and SMZ showed stimulation and inhibition on other biochemicals.Integrated biomarker response(IBR)index values showed that ERY and SMZ stimulated the overall metabolism in F1,and the stimulation decreased and even altered to inhibition in later generations.When comparing multi-and trans-generational effects,ERY and SMZ at high concentration caused inhibition on reproduction in T4 and stimulation in T4’,which were opposite to those in F1 and F4.展开更多
Traditionally, organizations assume that compensation/pay and monetary benefits are what all employees need to work harder, be productive, or remain with the company. According to Abraham Maslow, within every person i...Traditionally, organizations assume that compensation/pay and monetary benefits are what all employees need to work harder, be productive, or remain with the company. According to Abraham Maslow, within every person is a hierarchy of five needs： physiological needs, safety needs, social needs, esteem needs, and self-actualization needs Organizations must be able to identify what employees desire to secure optimum performance and to meet the needs of both employees and employers. This research focuses on the generational gap and the significance of intrinsic and extrinsic rewards in the workforce. The purpose and objective of this research are to test the significance of monetary versus non-monetary rewards among the different generations in the organization. A self-designed questionnaire distributed to a multi-generational group of employees of selected organizations was used to collect the analyzed data. Sixty-five （65%） responses were obtained. Secondary data were used to elucidate the needs in this area of study. Because the workforce is predicted to become more diverse in terms of age, organizations will be unlikely to implement one set of rewards for the multiple generations. This is due to the differing expectations and requirements among the generations. However, the results indicate no significant difference in monetary versus non-monetary rewards among the different generations in the workforce.展开更多
Under the background of population aging,while the living environment of the elderly is improved,it is necessary to pay attention to their spiritual needs and build an elderly-friendly and livable social environment.I...Under the background of population aging,while the living environment of the elderly is improved,it is necessary to pay attention to their spiritual needs and build an elderly-friendly and livable social environment.In this paper,through field investigation and research on social behavior and space,the social behavior and needs of the elderly in a university in the north were analyzed,and based on the social characteristics and psychological needs of the elderly and students in the university,the construction of a dynamic space with multi-generational shared space as the core was proposed to develop a social platform that integrates virtual and reality,so as to provide reference for the updating of social space in college communities in the future.展开更多
基金supported by grants from the National Key Research and Development Program of China(No.2020YFA0803900)the National Natural Science Foundation of China(Nos.82030111 and 81673524)+2 种基金the Major Technological Innovation Projects of Hubei Province(Nos.2019ACA140 and 2020BCA071)Hubei Province’s Outstanding Medical Academic Leader programMedical Science Advancement Program(Basic Medical Sciences)of Wuhan University(No.TFJC2018001)。
文摘Medication during pregnancy is widespread,but there are few reports on its fetal safety.Recent studies suggest that medication during pregnancy can affect fetal morphological and functional development through multiple pathways,multiple organs,and multiple targets.Its mechanisms involve direct ways such as oxidative stress,epigenetic modification,and metabolic activation,and it may also be indirectly caused by placental dysfunction.Further studies have found that medication during pregnancy may also indirectly lead to multi-organ developmental programming,functional homeostasis changes,and susceptibility to related diseases in offspring by inducing fetal intrauterine exposure to too high or too low levels of maternal-derived glucocorticoids.The organ developmental toxicity and programming alterations caused by medication during pregnancy may also have gender differences and multi-generational genetic effects mediated by abnormal epigenetic modification.Combined with the latest research results of our laboratory,this paper reviews the latest research progress on the developmental toxicity and functional programming alterations of multiple organs in offspring induced by medication during pregnancy,which can provide a theoretical and experimental basis for rational medication during pregnancy and effective prevention and treatment of drug-related multiple fetal-originated diseases.
基金supported by the the National Natural Science Foundation of China(No.21976138).
文摘Antibiotics are emerging pollutants with pseudo-persistence.However,their reproductive toxicities over generations and underlying mechanisms were seldom explored.In the present study,reproductive effects of erythromycin(ERY)and sulfamethoxazole(SMZ)were studied on Caenorhabditis elegans(C.elegans)with multi-generational exposure from F1 to F4,and their effects in the non-direct exposed offspring of F1 and F4(T4 and T4’)were explored to investigate trans-generational outcomes.At high concentrations,ERY and SMZ inhibited the reproduction and the inhibition decreased with more generations’exposure.At low concentrations,SMZ stimulated reproduction in T4,opposite to its inhibition in F1.Further analysis on ten enzymes and proteins in lipid and glucolipid metabolism showed that ERY commonly inhibited fatty acid synthetase(FAS)in F1 to F4,while ERY and SMZ showed stimulation and inhibition on other biochemicals.Integrated biomarker response(IBR)index values showed that ERY and SMZ stimulated the overall metabolism in F1,and the stimulation decreased and even altered to inhibition in later generations.When comparing multi-and trans-generational effects,ERY and SMZ at high concentration caused inhibition on reproduction in T4 and stimulation in T4’,which were opposite to those in F1 and F4.
文摘Traditionally, organizations assume that compensation/pay and monetary benefits are what all employees need to work harder, be productive, or remain with the company. According to Abraham Maslow, within every person is a hierarchy of five needs： physiological needs, safety needs, social needs, esteem needs, and self-actualization needs Organizations must be able to identify what employees desire to secure optimum performance and to meet the needs of both employees and employers. This research focuses on the generational gap and the significance of intrinsic and extrinsic rewards in the workforce. The purpose and objective of this research are to test the significance of monetary versus non-monetary rewards among the different generations in the organization. A self-designed questionnaire distributed to a multi-generational group of employees of selected organizations was used to collect the analyzed data. Sixty-five （65%） responses were obtained. Secondary data were used to elucidate the needs in this area of study. Because the workforce is predicted to become more diverse in terms of age, organizations will be unlikely to implement one set of rewards for the multiple generations. This is due to the differing expectations and requirements among the generations. However, the results indicate no significant difference in monetary versus non-monetary rewards among the different generations in the workforce.
文摘Under the background of population aging,while the living environment of the elderly is improved,it is necessary to pay attention to their spiritual needs and build an elderly-friendly and livable social environment.In this paper,through field investigation and research on social behavior and space,the social behavior and needs of the elderly in a university in the north were analyzed,and based on the social characteristics and psychological needs of the elderly and students in the university,the construction of a dynamic space with multi-generational shared space as the core was proposed to develop a social platform that integrates virtual and reality,so as to provide reference for the updating of social space in college communities in the future.
