Objective：To study the moxibustion at Guanyuan（CV 4）and Tianshu（ST 25）on intestinal dvsbacteriosis in rats.Methods：Fifty Wistar rats,clearing grade,were randomly divided into 5 groups,a normal group,a model grou...Objective：To study the moxibustion at Guanyuan（CV 4）and Tianshu（ST 25）on intestinal dvsbacteriosis in rats.Methods：Fifty Wistar rats,clearing grade,were randomly divided into 5 groups,a normal group,a model group,a medical group,and a Guanyuan（CV 4）group and a Tianshu（ST 25）group,with 10 rats in each group.The rats were treated with Lincomycin Hydrochloride via intragastric administration for developing models.The model rats were treated with medicine and moxibustion respectively.0.1 g fresh rat feces in each group were cultured on the selective culture medium of bifidobacterium species（BS）,lactobacillus（LBS）,enterobactefiaceae（EB）and enterococcus（EC）.The growth and quantity of the bacterial colony were tested by biochemical identification tubes and turbidimetry.Results：Moxibustion at Guanyuan（CV 4）increased BS and LBS while moxibustion at Tianshu（ST 25）improved EB and EC.Conclusion：Moxibustion at Front-Mu points Of different body parts selectively regulated advantaged probiotics for treating intestinal dysbactenosis.展开更多
Objective： To observe the effect of moxibustion on the expressions of tumor necrosis factor-α（TNF-α） and nuclear transcription factor kappa B（NF-κB） proteins in ankle joints of rats with rheumatoid arthritis...Objective： To observe the effect of moxibustion on the expressions of tumor necrosis factor-α（TNF-α） and nuclear transcription factor kappa B（NF-κB） proteins in ankle joints of rats with rheumatoid arthritis（RA）, and to explore the anti-inflammatory mechanism of moxibustion in the treatment of RA. Methods： Adjuvant arthritis（AA） rat models were induced and used as rat models of RA. Rats were randomly divided into a normal group, a model group, a moxibustion group and a saline group. Rats in the normal and model groups were not treated; rats in the moxibustion group accepted treatment by moxibustion at Zusanli（ST 36） and Shenshu（BL 23） after modeling; rats in the saline group were injected with 0.15 mL saline to the bottom of the left hind paw and had no other treatments. Hematoxylin-eosin（HE） staining was used to observe the histopathological changes of rats＇ ankle joints under light microscope. Immunohistochemistry was used to observe the expressions of TNF-α and NF-κB in ankle joints of rats. Results： Compared with the normal group, the rats＇ ankle joints in the model group showed disorganization, joint surface defect, and significantly increased mean optical density（MOD） of TNF-α and NF-κB（all P〈0.05）. After moxibustion treatment, rats in the moxibustion group showed repaired ankle tissues, smooth joint surface without defects, decreased MOD of TNF-α and NF-κB than those in the model group（all P〈0.05）. Rats in the saline group had no damage to ankle joints, while TNF-α and NF-κB were significantly different from those in the model group（P〈0.05）. Conclusion： Moxibustion could down-regulate the expressions of NF-κB and TNF-α protein in ankle joints of RA rats, and produce an anti-inflammatory effect to promote tissue repair.展开更多
Objective： To observe the effect of heat-sensitive moxibustion plus psychological intervention on serum contents of substance P（SP） and 5-hydroxytryptamine（5-HT）, as well as the quality of life（QOL） in patients...Objective： To observe the effect of heat-sensitive moxibustion plus psychological intervention on serum contents of substance P（SP） and 5-hydroxytryptamine（5-HT）, as well as the quality of life（QOL） in patients with irritable bowel syndrome（IBS）. Methods： A total of 120 IBS patients were divided into three groups by random sampling method, 40 cases in each group. The heat-sensitive moxibustion group received heat-sensitive moxibustion, the psychological intervention group received psychological intervention, while the observation group received both methods. The therapeutic efficacy was evaluated after 3 courses of treatment. Results： After treatment, the therapeutic efficacy of the observation group was better than that of the heat-sensitive moxibustion group and the psychological intervention group（P〈0.01）, and the heat-sensitive moxibsution group was better than the psychological intervention group（P〈0.05）. In comparing the bowel symptom scale（BSS）, the observation group was better than the other two groups（P〈0.05）, and there was a significant difference between the heat-sensitive moxibustion group and the psychological intervention group（P〈0.05）. In the comparison of QOL, the observation group was significantly superior to the other two groups（P〈0.05）, and there was a significant difference between the heat-sensitive moxibustion group and psychological intervention group（P〈0.05）. In comparing serum SP and 5-HT, the observation group was markedly better than the other two groups（P〈0.05）, and there were significant differences between the heat-sensitive moxibustion group and psychological intervention group（P〈0.05）. The self-rating anxiety scale（SAS） and self-rating depression scale（SDS） were used to estimate the mental state of the three groups, revealing that the observation group was better than the heat-sensitive moxibustion group and the psychological intervention group（P〈0.05）, and there were significant differences be展开更多
Objective:To observe the clinical effect of heat-sensitive moxibustion plus lactulose oral liquid for postoperative constipation of mixed hemorrhoid.Methods:A total of 70 patients were randomized into a treatment grou...Objective:To observe the clinical effect of heat-sensitive moxibustion plus lactulose oral liquid for postoperative constipation of mixed hemorrhoid.Methods:A total of 70 patients were randomized into a treatment group and a control group,with 35 cases in each group by a random number table.Patients in the control group received lactulose oral liquid alone,while those in the treatment group received additional heat-sensitive moxibustion at Shenque(CV 8).The treatment was given once a day for 15 consecutive days.The defecation interval time,defecation duration,the scores of stool form,visual analog scale(VAS)and patient assessment of constipation quality of life questionnaire(PAC-QOL),as well as the serum substance P(SP)and nitric oxide(NO)levels were measured before and after treatment.Results:After treatment,the stool form score,defecation interval time and defecation duration in the two groups dropped significantly(all P<0.05),and they were lower in the treatment group than in the control group(all P<0.05).After treatment,the VAS scores in the two groups dropped significantly(both P<0.05),and it was lower in the treatment group than in the control group(P<0.05).After treatment,the PAC-QOL scores in the two groups dropped significantly(both P<0.05),and it was lower in the treatment group than in the control group(P<0.05).After treatment,the serum SP and NO levels in the two groups improved significantly(all P<0.05),and showed statistically significant differences between the treatment group and the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus lactulose oral liquid can improve stool form,shorten defecation interval time and defecation duration,alleviate defecation pain,and improve quality of life(QOL)for patients with postoperative constipation of mixed hemorrhoid,which may be related to the regulation of the SP and NO levels.展开更多
Objective： To observe the effects of moxibustion at different times on prostaglandin E_2（PGE_2）, prostaglandin F2α（PGF_（2α））and arginine vasopressin（AVP）, in the uterine tissues of rats with dysmenorrhea du...Objective： To observe the effects of moxibustion at different times on prostaglandin E_2（PGE_2）, prostaglandin F2α（PGF_（2α））and arginine vasopressin（AVP）, in the uterine tissues of rats with dysmenorrhea due to cold-dampness retention, and to explore the differences and possible mechanisms of moxibustion at different times in easing pain in dysmenorrhea due to cold-dampness retention.Methods： Forty-three female Wistar rats were randomly divided into a blank control group（n=7）, a model group（n=9）,a pre-moxibustion group（n=9）, an immediate-moxibustion group（n=9） and a pre-moxibustion plus immediatemoxibustion group（n=9）. Rat models of primary dysmenorrhea due to cold-dampness retention were established using（0±1） ℃ ice water immersion method combined with injection of estradiol benzoate for 10 d, followed by injection of oxytocin on the 11 th day. Rats in the 3 intervention groups received moxibustion to Shenque（CV 8） and Guanyuan（CV 4）, 10 min for each acupoint, once a day. Rats in pre-moxibustion group were given mild moxibustion, beginning on the 8th day during modeling, for 3 continuous days; rats in immediate-moxibustion group were given one time mild moxibustion, immediately after injection of oxytocin on the 11 th day during modeling; rats in pre-moxibustion plus immediate-moxibustion group were given mild moxibustion, beginning on the 8th day during modeling till immediately after injection of oxytocin on the 11 th day during modeling, for 4 continuous days. The level of PGF_（2α） in the rat uterine tissues was measured by enzyme-linked immunosorbent assay（ELISA）, and the levels of PGE_2 and AVP in rat uterine tissues were measured by radioimmunoassay.Results： Compared with the blank control group, the levels of PGF_（2α） and AVP, the PGF_（2α）/PGE_2 ratio in the model group were significantly increased（P〈0.01）, and the PGE_2 level was significantly decreased（P〈0.01） in the rat uterine tissues in the model group. Compared展开更多
Objective： To observe the thermesthesia thresholds of the heat-sensitive acupoints in patients with knee osteoarthritis （KOA）, and to provide scientific evidence for acupoint selection based on acupoint sensitizati...Objective： To observe the thermesthesia thresholds of the heat-sensitive acupoints in patients with knee osteoarthritis （KOA）, and to provide scientific evidence for acupoint selection based on acupoint sensitization. Methods： Forty-six patients with KOA of swelling type were recruited. By using the quantitative thermesthesia testing, the thermal sensation threshold, thermal pain threshold, and threshold of thermal pain tolerance at Xuehai （SP 10）, Neixiyan （EX-LE 4） and Yinlingquan （SP 9） were detected. The subjects were then divided into heat-sensitive groups and non-heat-sensitive groups according to whether there was a phenomenon of heat-sensitive moxibustion sensation at each acupoint, to compare the thermesthesia thresholds between the two groups. Results： The thermal sensation threshold, thermal pain threshold, and threshold of thermal pain tolerance were respectively （38.21±2.03） ℃, （44.47±1.86） ℃ and （48.59＋0.74） ℃ in the heat-sensitive group of Xuehai （SP 10）, versus （36.76±1.93） ℃, （42.91±2.05） ℃ and （46.95±1.14） ℃ in the non-heat-sensitive group of Xuehai （SP 10）; the thermal sensation threshold, thermal pain threshold, and threshold of thermal pain tolerance were respectively （37.47±1.77）℃, （44.55＋1.63） ℃, and （47.48±0.47） ℃ in the heat-sensitive group of Neixiyan （EX-LE 4）, versus （35.92±1.69） ℃, （42.72±1.94）℃ and （45.53±0.41） ℃ in the non-heat-sensitive group of Neixiyan （EX-LE 4）; the thermal sensation threshold, thermal pain threshold, and threshold of thermal pain tolerance were respectively （37.30±2.23） ℃, （44.39±1.92） ℃ and （47.76±0.58） ℃ in the heat-sensitive group of Yinlingquan （SP 9）, versus （36.06±1.86） ℃, （42.63±1.88） ℃ and （45.91±0.72） ℃ in the non-heat-sensitive group of Yinlingquan （SP 9）. The statistical analyses showed that the thermal sensation threshold, thermal pain threshold, and threshold of thermal pain to展开更多
Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis(SOP),and to explore the related mechanisms.Methods:A total of 70 elderly participants with osteoporosis ...Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis(SOP),and to explore the related mechanisms.Methods:A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group,with 35 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs.Both groups were treated for 3 months.Before and after treatment,assessed the visual analog scale(VAS)and Oswestry disability index(ODI)scores,determined the bone mineral density of the participants'lumbar spine(L2-L4)and left femoral neck,and detected the participants'serum bone morphogenetic protein-2(BMP-2)and osteoprotegerin(OPG)levels.Results:After treatment,the VAS scores of both groups were lower than before treatment(both P<0.05),and the VAS score of the observation group was significantly lower than that of the control group(P<0.05).After treatment,the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment(both P<0.05),and the bone mineral density values of the observation group were higher than those of the control group(P<0.05).After treatment,the ODI scores of the two groups were lower than those before treatment(both P<0.05),and the ODI score of the observation group was lower than that of the control group(P<0.05).After treatment,the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients'pain,improve dysfunction,and increase bone density,which may be related to the improvement of the serum BMP-2 and OPG levels.展开更多
Objective： To discuss the safety issues of moxibustion therapy in view of moxibustion materials. Methods： The analyses and assessment were performed based on the survey carried out on the use of moxa, modem and anci...Objective： To discuss the safety issues of moxibustion therapy in view of moxibustion materials. Methods： The analyses and assessment were performed based on the survey carried out on the use of moxa, modem and ancient records, modem studies, and clinical applications. Results： Moxa has been used as both a medicine and a food for a long history in China. Regarding moxibustion specifically, moxa has been proven to be the optimum choice for moxibustion therapy, through practices and experiments by doctors from different generations. No records have shown any sideor adverse-effects of moxa applied in moxibustion therapy. Conclusion： Moxa has been used in multiple ways for several thousands of years by Chinese people. As the main material for moxibustion therapy, its safety has been proven by documents and clinical practices.展开更多
Objective： To observe the clinical effects in treatment of chronic heart failure with mild moxibustion plus medications. Methods： Sixty cases with chronic heart failure who met the inclusion criteria were randomly d...Objective： To observe the clinical effects in treatment of chronic heart failure with mild moxibustion plus medications. Methods： Sixty cases with chronic heart failure who met the inclusion criteria were randomly divided into two groups, 30 cases in each group. The treatment group was treated with mild moxibustion plus routine medications and the control group was treated only with routine medications, for comparing the clinical effects and relevant indexes of heart functions between the two groups after the treatment. Results： The heart rate （HR）, cardiac output （CO） and left ventricular ejection fraction （LVEF） were obviously improved in the two groups after the treatment （P0.01）, better in the treatment group than those in the control group （P0.01）. The total effective rate was better in the treatment group than that in the control group （P0.05）, indicating that both therapeutic programs were effective for chronic heart failure, but the clinical effect was better in the treatment group. Conclusion： The clinical effect is better in the treatment of chronic heart failure by mild moxibustion plus medications than by single application of medications.展开更多
Objective： To observe the effect of different moxibustion durations on rats with rheumatoid arthritis（RA） and to evaluate the relationship between moxibustion amount and moxibustion efficacy. Methods： Eight rats w...Objective： To observe the effect of different moxibustion durations on rats with rheumatoid arthritis（RA） and to evaluate the relationship between moxibustion amount and moxibustion efficacy. Methods： Eight rats were randomly selected as a normal group from the 40 male Sprague-Dawley（SD） rats, and the other 32 rats were used to establish type Ⅱ collagen-induced RA models. After successful modeling, the 32 rats were randomly divided into a model group, a moxibustion for 20 min group, a moxibustion for 40 min group and a moxibustion for 60 min group, with 8 rats in each group. Rats in the normal group did not receive modeling and moxibustion intervention; rats in the model group did not receive moxibustion after modeling; rats in the moxibustion for 20 min group, the moxibustion for 40 min group and the moxibustion for 60 min group were treated with moxibustion at Shenshu（BL 23） and Zusanli（ST 36） for 20 min, 40 min and 60 min, respectively. Six days were a course of treatment, with a total of 3-course treatments and a 1-day rest between the courses of treatment. After treatment, the serum levels of interleukin（IL）-1β and tumor necrosis factor（TNF）-α, arthritis index（AI） scores, toe volumes and pathological score of synovitis were evaluated in the rats. Results： Compared with the normal group, the serum IL-1β and TNF-α levels, and the toe volumes in the model group were increased, and the differences were statistically significant（P〈0.01）, before the treatment. Compared with the model group, the serum IL-1β and TNF-α levels, toe volumes and arthritis index（AI） scores were significantly decreased in the moxibustion for 20 min group, the moxibustion for 40 min group and the moxibustion for 60 min group（P〈0.05 or P〈0.01）. Compared with the moxibustion for 20 min group and the moxibustion for 60 min group, serum IL-1β and TNF-α levels, toe volumes and AI scores were decreased more significantly in moxibustion for 40 min group, and the differences were statis展开更多
OBTECTIVE:To explore the role of transient receptor potential vaniiloid subetype 1(TRPV1) in the increase of the thermal pain threshold by moxibustion.METHODS:Forty Kunming mice(20 ± 2) g were randomized into con...OBTECTIVE:To explore the role of transient receptor potential vaniiloid subetype 1(TRPV1) in the increase of the thermal pain threshold by moxibustion.METHODS:Forty Kunming mice(20 ± 2) g were randomized into control group,capsaicin group,capsazepine group,moxibustion group and moxibustion + capsazepine(MC) group with 8 mice in each,and 16 C57BL/6 wild-type mice(18 ± 2) g were randomized into wild-type(WT) control group and WT moxibustion group with 8 mice in each,and 14 TRPV1 knockout mice(18 ± 2) g were randomized into knockout(KO) control group and KO moxibustion group with 7 in each.Each mouse in the capsaicin group was subcutaneously injected with the amount of 0.1 mL/10 g into L5 and L6 spinal cords;each mouse in the capsazepine group was intraperitoneally injected with the amount of0.1 mL/10 g.Similarly,each mouse in the moxibustion group was given a suspended moxibustion with specially-made moxa-stick for 20 min on L5 and L6 spinal cords.Each mouse in MC group was intraperitoneally injected with the amount of 0.1 mL/10 g first,then after 15 min was given a suspended moxibustion for 20 min on L5 and L6 spinal cords.Each mouse in WT moxibustion group and KO moxibustion group was given a suspended moxibustion with specially-made moxa-stick for 20 min on L5 and L6 spinal cords.The control group,WT control group and KO control group were of no treatment in any way.After all treatments were completed,the digital-display measurement instrument for thermal pain was used to measure the threshold of thermal pain in each group respectively.RESULTS:Compared with the control group,the thresholds of thermal pain in the moxibustion group and MC group were significantly increased(P <0.01);no significant changes in the thresholds in the capsaicin group and the capsazepine group(P > 0.05);compared with moxibustion group,he threshold of thermal in MC group was obviously decreased(P < 0.01).Compared with WT control group,the threshold of thermal pain in WT moxibustion group was significantly increased(P <0.01);compared wi展开更多
Objective： A questionnaire for the compliance with moxibustion was designed based on the 4-item Morisky scale, and the reliability and validity of the questionnaire was investigated. Methods： A modified Morisky scal...Objective： A questionnaire for the compliance with moxibustion was designed based on the 4-item Morisky scale, and the reliability and validity of the questionnaire was investigated. Methods： A modified Morisky scale was designed based on the 4-item Morisky scale for the compliance with moxibustion, and 146 patients having received moxibustion for over 2 weeks were investigated using this scale to evaluate their compliance with moxibustion; the internal equity and the construct validity of the scale were statistically analyzed. Results： The analysis of reliability showed that in item of internal consistency, the Cronbach＇s α was 0.72 and the split-half coefficient was 0.71, the correlation coefficients between the 4 component scores and the total score ranged 0.67-0.80, and the between-component correlation coefficients ranged 0.24-0.56; the exploratory factor analysis（EFA） totally extracted 1 common factor, and the explicable variation was 55.02%, and the loads of the 4 items were respectively 0.82, 0.81, 0.74 and 0.58. Conclusion： The reliability and validity of the modified Morisky scale for the compliance with moxibustion are acceptable, while several items need further modification and improvement in the expression and content.展开更多
文摘Objective：To study the moxibustion at Guanyuan（CV 4）and Tianshu（ST 25）on intestinal dvsbacteriosis in rats.Methods：Fifty Wistar rats,clearing grade,were randomly divided into 5 groups,a normal group,a model group,a medical group,and a Guanyuan（CV 4）group and a Tianshu（ST 25）group,with 10 rats in each group.The rats were treated with Lincomycin Hydrochloride via intragastric administration for developing models.The model rats were treated with medicine and moxibustion respectively.0.1 g fresh rat feces in each group were cultured on the selective culture medium of bifidobacterium species（BS）,lactobacillus（LBS）,enterobactefiaceae（EB）and enterococcus（EC）.The growth and quantity of the bacterial colony were tested by biochemical identification tubes and turbidimetry.Results：Moxibustion at Guanyuan（CV 4）increased BS and LBS while moxibustion at Tianshu（ST 25）improved EB and EC.Conclusion：Moxibustion at Front-Mu points Of different body parts selectively regulated advantaged probiotics for treating intestinal dysbactenosis.
基金supported by Youth Project of Anhui Provincial Natural Science Foundation,No.1508085QH160Youth Scientific Research Fund Project of Anhui University of Chinese Medicine,No.2014qn004+1 种基金2016 Undergraduate Innovation and Entrepreneurship Training Program of Anhui University of Chinese Medicine,No.2016097Innovation Team Project of Scientific Research Platform for Universities in Anhui Province,No.2015TD033~~
文摘Objective： To observe the effect of moxibustion on the expressions of tumor necrosis factor-α（TNF-α） and nuclear transcription factor kappa B（NF-κB） proteins in ankle joints of rats with rheumatoid arthritis（RA）, and to explore the anti-inflammatory mechanism of moxibustion in the treatment of RA. Methods： Adjuvant arthritis（AA） rat models were induced and used as rat models of RA. Rats were randomly divided into a normal group, a model group, a moxibustion group and a saline group. Rats in the normal and model groups were not treated; rats in the moxibustion group accepted treatment by moxibustion at Zusanli（ST 36） and Shenshu（BL 23） after modeling; rats in the saline group were injected with 0.15 mL saline to the bottom of the left hind paw and had no other treatments. Hematoxylin-eosin（HE） staining was used to observe the histopathological changes of rats＇ ankle joints under light microscope. Immunohistochemistry was used to observe the expressions of TNF-α and NF-κB in ankle joints of rats. Results： Compared with the normal group, the rats＇ ankle joints in the model group showed disorganization, joint surface defect, and significantly increased mean optical density（MOD） of TNF-α and NF-κB（all P〈0.05）. After moxibustion treatment, rats in the moxibustion group showed repaired ankle tissues, smooth joint surface without defects, decreased MOD of TNF-α and NF-κB than those in the model group（all P〈0.05）. Rats in the saline group had no damage to ankle joints, while TNF-α and NF-κB were significantly different from those in the model group（P〈0.05）. Conclusion： Moxibustion could down-regulate the expressions of NF-κB and TNF-α protein in ankle joints of RA rats, and produce an anti-inflammatory effect to promote tissue repair.
文摘Objective： To observe the effect of heat-sensitive moxibustion plus psychological intervention on serum contents of substance P（SP） and 5-hydroxytryptamine（5-HT）, as well as the quality of life（QOL） in patients with irritable bowel syndrome（IBS）. Methods： A total of 120 IBS patients were divided into three groups by random sampling method, 40 cases in each group. The heat-sensitive moxibustion group received heat-sensitive moxibustion, the psychological intervention group received psychological intervention, while the observation group received both methods. The therapeutic efficacy was evaluated after 3 courses of treatment. Results： After treatment, the therapeutic efficacy of the observation group was better than that of the heat-sensitive moxibustion group and the psychological intervention group（P〈0.01）, and the heat-sensitive moxibsution group was better than the psychological intervention group（P〈0.05）. In comparing the bowel symptom scale（BSS）, the observation group was better than the other two groups（P〈0.05）, and there was a significant difference between the heat-sensitive moxibustion group and the psychological intervention group（P〈0.05）. In the comparison of QOL, the observation group was significantly superior to the other two groups（P〈0.05）, and there was a significant difference between the heat-sensitive moxibustion group and psychological intervention group（P〈0.05）. In comparing serum SP and 5-HT, the observation group was markedly better than the other two groups（P〈0.05）, and there were significant differences between the heat-sensitive moxibustion group and psychological intervention group（P〈0.05）. The self-rating anxiety scale（SAS） and self-rating depression scale（SDS） were used to estimate the mental state of the three groups, revealing that the observation group was better than the heat-sensitive moxibustion group and the psychological intervention group（P〈0.05）, and there were significant differences be
文摘Objective:To observe the clinical effect of heat-sensitive moxibustion plus lactulose oral liquid for postoperative constipation of mixed hemorrhoid.Methods:A total of 70 patients were randomized into a treatment group and a control group,with 35 cases in each group by a random number table.Patients in the control group received lactulose oral liquid alone,while those in the treatment group received additional heat-sensitive moxibustion at Shenque(CV 8).The treatment was given once a day for 15 consecutive days.The defecation interval time,defecation duration,the scores of stool form,visual analog scale(VAS)and patient assessment of constipation quality of life questionnaire(PAC-QOL),as well as the serum substance P(SP)and nitric oxide(NO)levels were measured before and after treatment.Results:After treatment,the stool form score,defecation interval time and defecation duration in the two groups dropped significantly(all P<0.05),and they were lower in the treatment group than in the control group(all P<0.05).After treatment,the VAS scores in the two groups dropped significantly(both P<0.05),and it was lower in the treatment group than in the control group(P<0.05).After treatment,the PAC-QOL scores in the two groups dropped significantly(both P<0.05),and it was lower in the treatment group than in the control group(P<0.05).After treatment,the serum SP and NO levels in the two groups improved significantly(all P<0.05),and showed statistically significant differences between the treatment group and the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus lactulose oral liquid can improve stool form,shorten defecation interval time and defecation duration,alleviate defecation pain,and improve quality of life(QOL)for patients with postoperative constipation of mixed hemorrhoid,which may be related to the regulation of the SP and NO levels.
基金supported by Science and Technology Support Project of Hebei Provincial Administration of Traditional Chinese Medicine,No.2015089Science and Technology Research Project of Universities in Hebei Province,No.QN2015027Undergraduate Student Innovation Project of Hebei Province Education Office,No.201514432017~~
文摘Objective： To observe the effects of moxibustion at different times on prostaglandin E_2（PGE_2）, prostaglandin F2α（PGF_（2α））and arginine vasopressin（AVP）, in the uterine tissues of rats with dysmenorrhea due to cold-dampness retention, and to explore the differences and possible mechanisms of moxibustion at different times in easing pain in dysmenorrhea due to cold-dampness retention.Methods： Forty-three female Wistar rats were randomly divided into a blank control group（n=7）, a model group（n=9）,a pre-moxibustion group（n=9）, an immediate-moxibustion group（n=9） and a pre-moxibustion plus immediatemoxibustion group（n=9）. Rat models of primary dysmenorrhea due to cold-dampness retention were established using（0±1） ℃ ice water immersion method combined with injection of estradiol benzoate for 10 d, followed by injection of oxytocin on the 11 th day. Rats in the 3 intervention groups received moxibustion to Shenque（CV 8） and Guanyuan（CV 4）, 10 min for each acupoint, once a day. Rats in pre-moxibustion group were given mild moxibustion, beginning on the 8th day during modeling, for 3 continuous days; rats in immediate-moxibustion group were given one time mild moxibustion, immediately after injection of oxytocin on the 11 th day during modeling; rats in pre-moxibustion plus immediate-moxibustion group were given mild moxibustion, beginning on the 8th day during modeling till immediately after injection of oxytocin on the 11 th day during modeling, for 4 continuous days. The level of PGF_（2α） in the rat uterine tissues was measured by enzyme-linked immunosorbent assay（ELISA）, and the levels of PGE_2 and AVP in rat uterine tissues were measured by radioimmunoassay.Results： Compared with the blank control group, the levels of PGF_（2α） and AVP, the PGF_（2α）/PGE_2 ratio in the model group were significantly increased（P〈0.01）, and the PGE_2 level was significantly decreased（P〈0.01） in the rat uterine tissues in the model group. Compared
基金supported by the National Basic Research Program of China 973 Program(No.2015CB554503)Traditional Chinese Medicine Scientific Research Plan of Jiangxi Province Health Department(No.2013A099)~~
文摘Objective： To observe the thermesthesia thresholds of the heat-sensitive acupoints in patients with knee osteoarthritis （KOA）, and to provide scientific evidence for acupoint selection based on acupoint sensitization. Methods： Forty-six patients with KOA of swelling type were recruited. By using the quantitative thermesthesia testing, the thermal sensation threshold, thermal pain threshold, and threshold of thermal pain tolerance at Xuehai （SP 10）, Neixiyan （EX-LE 4） and Yinlingquan （SP 9） were detected. The subjects were then divided into heat-sensitive groups and non-heat-sensitive groups according to whether there was a phenomenon of heat-sensitive moxibustion sensation at each acupoint, to compare the thermesthesia thresholds between the two groups. Results： The thermal sensation threshold, thermal pain threshold, and threshold of thermal pain tolerance were respectively （38.21±2.03） ℃, （44.47±1.86） ℃ and （48.59＋0.74） ℃ in the heat-sensitive group of Xuehai （SP 10）, versus （36.76±1.93） ℃, （42.91±2.05） ℃ and （46.95±1.14） ℃ in the non-heat-sensitive group of Xuehai （SP 10）; the thermal sensation threshold, thermal pain threshold, and threshold of thermal pain tolerance were respectively （37.47±1.77）℃, （44.55＋1.63） ℃, and （47.48±0.47） ℃ in the heat-sensitive group of Neixiyan （EX-LE 4）, versus （35.92±1.69） ℃, （42.72±1.94）℃ and （45.53±0.41） ℃ in the non-heat-sensitive group of Neixiyan （EX-LE 4）; the thermal sensation threshold, thermal pain threshold, and threshold of thermal pain tolerance were respectively （37.30±2.23） ℃, （44.39±1.92） ℃ and （47.76±0.58） ℃ in the heat-sensitive group of Yinlingquan （SP 9）, versus （36.06±1.86） ℃, （42.63±1.88） ℃ and （45.91±0.72） ℃ in the non-heat-sensitive group of Yinlingquan （SP 9）. The statistical analyses showed that the thermal sensation threshold, thermal pain threshold, and threshold of thermal pain to
文摘Objective:To observe the clinical efficacy of heat-sensitive moxibustion plus medications on senile osteoporosis(SOP),and to explore the related mechanisms.Methods:A total of 70 elderly participants with osteoporosis were randomly divided into an observation group and control group,with 35 cases in each group.The control group was treated with conventional drugs,and the observation group was treated with heat-sensitive moxibustion on the basis of the conventional drugs.Both groups were treated for 3 months.Before and after treatment,assessed the visual analog scale(VAS)and Oswestry disability index(ODI)scores,determined the bone mineral density of the participants'lumbar spine(L2-L4)and left femoral neck,and detected the participants'serum bone morphogenetic protein-2(BMP-2)and osteoprotegerin(OPG)levels.Results:After treatment,the VAS scores of both groups were lower than before treatment(both P<0.05),and the VAS score of the observation group was significantly lower than that of the control group(P<0.05).After treatment,the bone mineral density values of the lumbar spine and left femoral neck in both groups were significantly higher than before treatment(both P<0.05),and the bone mineral density values of the observation group were higher than those of the control group(P<0.05).After treatment,the ODI scores of the two groups were lower than those before treatment(both P<0.05),and the ODI score of the observation group was lower than that of the control group(P<0.05).After treatment,the serum BMP-2 and OPG levels in the observation group were significantly higher than those in the control group(both P<0.05).Conclusion:Heat-sensitive moxibustion plus medications for SOP can significantly relieve patients'pain,improve dysfunction,and increase bone density,which may be related to the improvement of the serum BMP-2 and OPG levels.
文摘Objective： To discuss the safety issues of moxibustion therapy in view of moxibustion materials. Methods： The analyses and assessment were performed based on the survey carried out on the use of moxa, modem and ancient records, modem studies, and clinical applications. Results： Moxa has been used as both a medicine and a food for a long history in China. Regarding moxibustion specifically, moxa has been proven to be the optimum choice for moxibustion therapy, through practices and experiments by doctors from different generations. No records have shown any sideor adverse-effects of moxa applied in moxibustion therapy. Conclusion： Moxa has been used in multiple ways for several thousands of years by Chinese people. As the main material for moxibustion therapy, its safety has been proven by documents and clinical practices.
基金supported by Clinical School of Acupuncture and Orthopedics, Anhui College of Traditional Chinese Medicine and Second Hospital Affiliated to Anhui College of Traditional Chinese Medicine
文摘Objective： To observe the clinical effects in treatment of chronic heart failure with mild moxibustion plus medications. Methods： Sixty cases with chronic heart failure who met the inclusion criteria were randomly divided into two groups, 30 cases in each group. The treatment group was treated with mild moxibustion plus routine medications and the control group was treated only with routine medications, for comparing the clinical effects and relevant indexes of heart functions between the two groups after the treatment. Results： The heart rate （HR）, cardiac output （CO） and left ventricular ejection fraction （LVEF） were obviously improved in the two groups after the treatment （P0.01）, better in the treatment group than those in the control group （P0.01）. The total effective rate was better in the treatment group than that in the control group （P0.05）, indicating that both therapeutic programs were effective for chronic heart failure, but the clinical effect was better in the treatment group. Conclusion： The clinical effect is better in the treatment of chronic heart failure by mild moxibustion plus medications than by single application of medications.
基金supported by Qing Lan Project of Jiangsu Province,No.2014In novation Plan Project for Academic Degree Graduate Students of Colleges and Universities in Jiangsu Province,No.KYLX16_1164+1 种基金Innovation and Entrepreneurship Training Key Project for Undergraduates of Colleges and U niversities in Jiangsu Province,No.201610315015ZCommand Subject of Jiangsu Provincial Advantage Disciplines PhaseⅡProject and Nanjing University of Chinese Medicine Nursing First-level Discipline,No.YSHL2016-015~~
文摘Objective： To observe the effect of different moxibustion durations on rats with rheumatoid arthritis（RA） and to evaluate the relationship between moxibustion amount and moxibustion efficacy. Methods： Eight rats were randomly selected as a normal group from the 40 male Sprague-Dawley（SD） rats, and the other 32 rats were used to establish type Ⅱ collagen-induced RA models. After successful modeling, the 32 rats were randomly divided into a model group, a moxibustion for 20 min group, a moxibustion for 40 min group and a moxibustion for 60 min group, with 8 rats in each group. Rats in the normal group did not receive modeling and moxibustion intervention; rats in the model group did not receive moxibustion after modeling; rats in the moxibustion for 20 min group, the moxibustion for 40 min group and the moxibustion for 60 min group were treated with moxibustion at Shenshu（BL 23） and Zusanli（ST 36） for 20 min, 40 min and 60 min, respectively. Six days were a course of treatment, with a total of 3-course treatments and a 1-day rest between the courses of treatment. After treatment, the serum levels of interleukin（IL）-1β and tumor necrosis factor（TNF）-α, arthritis index（AI） scores, toe volumes and pathological score of synovitis were evaluated in the rats. Results： Compared with the normal group, the serum IL-1β and TNF-α levels, and the toe volumes in the model group were increased, and the differences were statistically significant（P〈0.01）, before the treatment. Compared with the model group, the serum IL-1β and TNF-α levels, toe volumes and arthritis index（AI） scores were significantly decreased in the moxibustion for 20 min group, the moxibustion for 40 min group and the moxibustion for 60 min group（P〈0.05 or P〈0.01）. Compared with the moxibustion for 20 min group and the moxibustion for 60 min group, serum IL-1β and TNF-α levels, toe volumes and AI scores were decreased more significantly in moxibustion for 40 min group, and the differences were statis
基金Supported by National Key Basic Research Program 973(Dual Effects of Acupuncture on Functional Intestinal Disease and Its Relationship with Autonomic Nervous Function,No.2011cb505206)2013 Jiangsu Province Education Department of Natural Science Research of Major Projects(Research on The Role of Trpv1 About Anti-inflammation And Analgesia Effect of Moxibustion Treatment,No.13kja360001)Academic Propagate Project on Scientific And Technical Innovation Team,Nanjing University Of Chinese Medicine 2013 Scientific And Technical Innovation Team Project
文摘OBTECTIVE:To explore the role of transient receptor potential vaniiloid subetype 1(TRPV1) in the increase of the thermal pain threshold by moxibustion.METHODS:Forty Kunming mice(20 ± 2) g were randomized into control group,capsaicin group,capsazepine group,moxibustion group and moxibustion + capsazepine(MC) group with 8 mice in each,and 16 C57BL/6 wild-type mice(18 ± 2) g were randomized into wild-type(WT) control group and WT moxibustion group with 8 mice in each,and 14 TRPV1 knockout mice(18 ± 2) g were randomized into knockout(KO) control group and KO moxibustion group with 7 in each.Each mouse in the capsaicin group was subcutaneously injected with the amount of 0.1 mL/10 g into L5 and L6 spinal cords;each mouse in the capsazepine group was intraperitoneally injected with the amount of0.1 mL/10 g.Similarly,each mouse in the moxibustion group was given a suspended moxibustion with specially-made moxa-stick for 20 min on L5 and L6 spinal cords.Each mouse in MC group was intraperitoneally injected with the amount of 0.1 mL/10 g first,then after 15 min was given a suspended moxibustion for 20 min on L5 and L6 spinal cords.Each mouse in WT moxibustion group and KO moxibustion group was given a suspended moxibustion with specially-made moxa-stick for 20 min on L5 and L6 spinal cords.The control group,WT control group and KO control group were of no treatment in any way.After all treatments were completed,the digital-display measurement instrument for thermal pain was used to measure the threshold of thermal pain in each group respectively.RESULTS:Compared with the control group,the thresholds of thermal pain in the moxibustion group and MC group were significantly increased(P <0.01);no significant changes in the thresholds in the capsaicin group and the capsazepine group(P > 0.05);compared with moxibustion group,he threshold of thermal in MC group was obviously decreased(P < 0.01).Compared with WT control group,the threshold of thermal pain in WT moxibustion group was significantly increased(P <0.01);compared wi
基金supported by National Basic Research Program of China,973 Program~~
文摘Objective： A questionnaire for the compliance with moxibustion was designed based on the 4-item Morisky scale, and the reliability and validity of the questionnaire was investigated. Methods： A modified Morisky scale was designed based on the 4-item Morisky scale for the compliance with moxibustion, and 146 patients having received moxibustion for over 2 weeks were investigated using this scale to evaluate their compliance with moxibustion; the internal equity and the construct validity of the scale were statistically analyzed. Results： The analysis of reliability showed that in item of internal consistency, the Cronbach＇s α was 0.72 and the split-half coefficient was 0.71, the correlation coefficients between the 4 component scores and the total score ranged 0.67-0.80, and the between-component correlation coefficients ranged 0.24-0.56; the exploratory factor analysis（EFA） totally extracted 1 common factor, and the explicable variation was 55.02%, and the loads of the 4 items were respectively 0.82, 0.81, 0.74 and 0.58. Conclusion： The reliability and validity of the modified Morisky scale for the compliance with moxibustion are acceptable, while several items need further modification and improvement in the expression and content.
