Purpose: To the investigate changes in local immune functions of the cornea and the adjacent conjunctiva, and their roles in the mechanism of the disease. Method: The cornea and adjacent bulbar conjunctiva taken from ...Purpose: To the investigate changes in local immune functions of the cornea and the adjacent conjunctiva, and their roles in the mechanism of the disease. Method: The cornea and adjacent bulbar conjunctiva taken from 14 patients with Mooren’s ulcer were stained immunohistochemically for CD3, CD4, CD8, HLA-DR, GD1 and CD25.Result: An aberrant expression of HLA-DR antigen by a large number of kerato-conjunctival epithelial cells and keratocytes in the corneal stroma was found. The CD4 + /CD8+ ratio is significantly higher than normal control. Conclusion: The aberrant expression of MHC- II antigen in the resident cells at the peripheral cornea and the adjacent conjunctiva, along with a raised local TH/ Ts ratio leading to an excessive autoimmune reactivity is possibly the direct cause of Mooren’s ulcer. Eye Science 1996; 12: 33-35.展开更多
AIM:To analyze indications and reasons for failure of anterior lamellar keratoplasty(ALK).METHODS:The clinical records were retrospectively reviewed.Main outcome measures included indications for ALK and reasons f...AIM:To analyze indications and reasons for failure of anterior lamellar keratoplasty(ALK).METHODS:The clinical records were retrospectively reviewed.Main outcome measures included indications for ALK and reasons for failure of ALK.RESULTS:A total of 434 patients(462 eyes) were treated with ALK at Qingdao Eye Hospital,Shandong Eye Institute from June 1,2009 to May 31,2016.The main indications were infectious keratitis(33.3%),keratoconus(23.6%),corneal dystrophy and degeneration(9.8%),Mooren's ulcer(8.4%),corneal neoplasm(7.8%),viral keratitis(6.5%) and regrafting(3.7%).Fungal keratitis accounted for 73.4% in the infectious keratitis cases.ALKs were failed in 36 patients,with the major causes being recurrence of primary diseases(63.9%).The leading causes of graft failure was Mooren's ulcer(36.1%),followed by infectious keratitis(30.6%).Recurrence of fungal keratitis accounted for 81.8% in the failed cases after ALK for infectious keratitis cases.CONCLUSION:Infectious keratitis and keratoconus are the main indications for ALK,of which fungal keratitis was the major cause of corneal infections.Recurrence of primary disease is the main reason of graft failure after ALK,in which the main primary diseases associated with graft failure are Mooren's ulcer and fungal keratitis.展开更多
文摘Purpose: To the investigate changes in local immune functions of the cornea and the adjacent conjunctiva, and their roles in the mechanism of the disease. Method: The cornea and adjacent bulbar conjunctiva taken from 14 patients with Mooren’s ulcer were stained immunohistochemically for CD3, CD4, CD8, HLA-DR, GD1 and CD25.Result: An aberrant expression of HLA-DR antigen by a large number of kerato-conjunctival epithelial cells and keratocytes in the corneal stroma was found. The CD4 + /CD8+ ratio is significantly higher than normal control. Conclusion: The aberrant expression of MHC- II antigen in the resident cells at the peripheral cornea and the adjacent conjunctiva, along with a raised local TH/ Ts ratio leading to an excessive autoimmune reactivity is possibly the direct cause of Mooren’s ulcer. Eye Science 1996; 12: 33-35.
基金Supported by the National Natural Science Foundation of China(No.81500703)the Natural Science Foundation of Shandong Province(No.ZR2015YL027)
文摘AIM:To analyze indications and reasons for failure of anterior lamellar keratoplasty(ALK).METHODS:The clinical records were retrospectively reviewed.Main outcome measures included indications for ALK and reasons for failure of ALK.RESULTS:A total of 434 patients(462 eyes) were treated with ALK at Qingdao Eye Hospital,Shandong Eye Institute from June 1,2009 to May 31,2016.The main indications were infectious keratitis(33.3%),keratoconus(23.6%),corneal dystrophy and degeneration(9.8%),Mooren's ulcer(8.4%),corneal neoplasm(7.8%),viral keratitis(6.5%) and regrafting(3.7%).Fungal keratitis accounted for 73.4% in the infectious keratitis cases.ALKs were failed in 36 patients,with the major causes being recurrence of primary diseases(63.9%).The leading causes of graft failure was Mooren's ulcer(36.1%),followed by infectious keratitis(30.6%).Recurrence of fungal keratitis accounted for 81.8% in the failed cases after ALK for infectious keratitis cases.CONCLUSION:Infectious keratitis and keratoconus are the main indications for ALK,of which fungal keratitis was the major cause of corneal infections.Recurrence of primary disease is the main reason of graft failure after ALK,in which the main primary diseases associated with graft failure are Mooren's ulcer and fungal keratitis.