Objective:To investigate the effect of Modified Xiaochaihu Decoction(MXD,加味小柴胡汤)on collagen degradation in rats with chronic pancreatitis(CP).Methods:Rats were injected dibutyltin dichloride(DBTC,7 mg/kg of body...Objective:To investigate the effect of Modified Xiaochaihu Decoction(MXD,加味小柴胡汤)on collagen degradation in rats with chronic pancreatitis(CP).Methods:Rats were injected dibutyltin dichloride(DBTC,7 mg/kg of body weight)into the right caudal vein to induce CP model.Thirty heallhy male Wistar rats were randomly divided into three groups by a random number table:the control,the model and the treatment groups.Rats of treatment group were administered MXD(10 g/kg of body weight)orally once daily starting from the day post-model establishment.Pancreatic tissues were harvested after 28-day feeding and fibrosis was evaluated by picro-sirius red staining.The contents of collagen typeⅠandⅢwere detected using enzymelinked immunosorbent assay(ELISA),the expression of matrix metalloproteinase 13(MMP13)and tissue inhibitor of metalloproteinase 1(TIMP1)was analyzed by Western blot and real-time polymerase chain reaction(PCR).Results:The fibrosis scoring of pancreatic tissues,the concentrations of collagen typeⅠandⅢ,the expression levels of MMP13 and TIMP1 proteins and mRNA in the model group were all increased compared with the control group(P<0.05).After treatment with MXD,the fibrosis scoring of pancreatic tissues,the concentrations of collagen typeⅠandⅢ,the expression levels of MMP13 proteins and m RNA in the teatment group were all decreased compared with the model group(P<0.05),but there were no significant differences in the expression levels of TIMP1 proteins and m RNA(P>0.05).Conclusion:MXD could promote collagen degradation and reverse pancreatic fibrosis in CP rats via a mechanism involve up-regulation of MMP13 expression.展开更多
Tooth presents an intriguing option as a bone graft due to its compositional similarity to bone.However,the deproteinized human demineralized tooth matrix(dpDTM),developed to overcome the limited availability of autol...Tooth presents an intriguing option as a bone graft due to its compositional similarity to bone.However,the deproteinized human demineralized tooth matrix(dpDTM),developed to overcome the limited availability of autologous tooth grafts,has suboptimal pore size and surface roughness.This study aimed to fabricate a surface-modified dpDTM using acid etching and collagen coating,followed by in vitro evaluation of physicochemical and biological properties.The dpDTM was modified into two protocols:Acid-modified dpDTM(A-dpDTM)and collagen-modified dpDTM(C-dpDTM).Results demonstrated that A-dpDTM and C-dpDTM had increased pore sizes and rougher surfaces compared to dpDTM.Collagen immobilization was evidenced by nitrogen presence exclusively in C-dpDTM.All groups had a Ca/P molar ratio of 1.67 and hydroxyapatite as the sole constituent,with 65-67%crystallinity.Degradation rates significantly increased to 30%and 20%for C-dpDTM and A-dpDTM,respectively,compared to 10%for dpDTM after 120 days.Cumulative collagen release of C-dpDTM on Day 30 was 45.16 mg/ml.Osteoblasts attachment and proliferation were enhanced on all scaffolds,especially C-dpDTM,which displayed the highest proliferation and differentiation rates.In conclusion,surface modified of dpDTM,including A-dpDTM and C-dpDTM,significantly enhances bioactivity by altering surface properties and promoting osteoblast activity,thereby demonstrating promise for bone regeneration applications.展开更多
This paper proposes a novel control approach for fault-tolerant control of dual three-phase permanent magnet synchronous motor(PMSM) under one-phase open-circuit fault.A modified six-phase static coordinate transforma...This paper proposes a novel control approach for fault-tolerant control of dual three-phase permanent magnet synchronous motor(PMSM) under one-phase open-circuit fault.A modified six-phase static coordinate transformation matrix and an extended rotating coordinate transformation matrix are investigated considering the influence of the fifth harmonic space on fault-tolerant control. These mathematical models are further analyzed in the fundamental space and the fifth harmonic space after the fault and to eliminate the coupling between the d-q axis voltage equation in the fundamental wave space and the d-q axis voltage equation in the fifth harmonic space, a secondary rotation coordinate transformation matrix is proposed. To achieve the purpose of reducing torque ripple, the fault-tolerant control method proposed in this paper not only takes the minimum copper loss as the constraint condition, but also injects the fifth harmonic current. The experimental result of current and torque is used to verify the accuracy of fault-tolerant control.展开更多
This paper presents a new solution to the problem of transmission cost allocation to its users.The proposed technique utilizes modified Z-bus theory,equivalent current injection and impedance of the generators and loa...This paper presents a new solution to the problem of transmission cost allocation to its users.The proposed technique utilizes modified Z-bus theory,equivalent current injection and impedance of the generators and loads,and is developed by the equal-sharing as well as the orthogonal projection principle.The procedure is performed in three steps.First,the modified Z-bus theory is used to calculate the contribution of the users into the network bus voltages as well as the branch currents.Then,the equal sharing principle is confirmed by the game theory solutions and is subsequently applied to identify the users’contributions into the branch power flows.After that,the orthogonal projections of the contributions are calculated and the concept of effective contributions is suggested.The proposed methodology provides the percentage shares of the users on the network complex variables,which help to better assess the contributions.A 2-bus and the IEEE 30-bus test system are used to validate the proposed technique.Finally,the proposed methodology is applied to the polish 2383-bus system to emphasize its applicability to large practical systems.展开更多
In this paper,we propose a new biased estimator namely modified almost unbiased Liu estimator by combining almost unbiased Liu estimator(AULE)andridge estimator(RE)in a linear regression model when multicollinearity p...In this paper,we propose a new biased estimator namely modified almost unbiased Liu estimator by combining almost unbiased Liu estimator(AULE)andridge estimator(RE)in a linear regression model when multicollinearity presents amongthe independent variables.Necessary and sufficient conditions for the proposed estimator over the ordinary least square estimator,RE,AULE and Liu estimator(LE)in the mean squared error matrix sense are derived,and the optimal biasing parameters are obtained.To illustrate the theoretical findings,a Monte Carlo simulation study is carried out and a numerical example is used.展开更多
The modified shear lag model proposed recently was applied to calculate thermal residual stresses and subsequent stress distributions under tensile and compressive loadings. The expressions for the elastic moduli and ...The modified shear lag model proposed recently was applied to calculate thermal residual stresses and subsequent stress distributions under tensile and compressive loadings. The expressions for the elastic moduli and the yield strengths under tensile and compressive loadings were derived which take account of thermal residual stresses. The asymmetries in the elastic modulus and the yield strength were interpreted using the derived expressions and the obtained results of the stress calculations. The model predictions have exhibited good agreements with the experimental results and also with the other theoretical predictions展开更多
In this article,we propose a new biased estimator,namely stochastic restricted modified almost unbiased Liu estimator by combining modified almost unbiased Liu estimator(MAULE)and mixed estimator(ME)when the stochasti...In this article,we propose a new biased estimator,namely stochastic restricted modified almost unbiased Liu estimator by combining modified almost unbiased Liu estimator(MAULE)and mixed estimator(ME)when the stochastic restrictions are available and the multicollinearity presents.The conditions of supe-riority of the proposed estimator over the ordinary least square estimator,ME,ridge estimator,Liu estimator,almost unbiased Liu estimator,stochastic restricted Liu esti-mator and MAULE in the mean squared error matrix sense are obtained.Finally,a numerical example and a Monte Carlo simulation are given to illustrate the theoretical findings.展开更多
基金Supported by the National Natural Science Foundation of China(No.81102686)。
文摘Objective:To investigate the effect of Modified Xiaochaihu Decoction(MXD,加味小柴胡汤)on collagen degradation in rats with chronic pancreatitis(CP).Methods:Rats were injected dibutyltin dichloride(DBTC,7 mg/kg of body weight)into the right caudal vein to induce CP model.Thirty heallhy male Wistar rats were randomly divided into three groups by a random number table:the control,the model and the treatment groups.Rats of treatment group were administered MXD(10 g/kg of body weight)orally once daily starting from the day post-model establishment.Pancreatic tissues were harvested after 28-day feeding and fibrosis was evaluated by picro-sirius red staining.The contents of collagen typeⅠandⅢwere detected using enzymelinked immunosorbent assay(ELISA),the expression of matrix metalloproteinase 13(MMP13)and tissue inhibitor of metalloproteinase 1(TIMP1)was analyzed by Western blot and real-time polymerase chain reaction(PCR).Results:The fibrosis scoring of pancreatic tissues,the concentrations of collagen typeⅠandⅢ,the expression levels of MMP13 and TIMP1 proteins and mRNA in the model group were all increased compared with the control group(P<0.05).After treatment with MXD,the fibrosis scoring of pancreatic tissues,the concentrations of collagen typeⅠandⅢ,the expression levels of MMP13 proteins and m RNA in the teatment group were all decreased compared with the model group(P<0.05),but there were no significant differences in the expression levels of TIMP1 proteins and m RNA(P>0.05).Conclusion:MXD could promote collagen degradation and reverse pancreatic fibrosis in CP rats via a mechanism involve up-regulation of MMP13 expression.
基金supported by National Science,Research and Innovation Fund(NSRF)and Prince of Songkla University(Ref.No.DEN6701281S)Cranio-Maxillofacial Hard Tissue Engineering Center,Faculty of Dentistry,Prince of Songkla University.
文摘Tooth presents an intriguing option as a bone graft due to its compositional similarity to bone.However,the deproteinized human demineralized tooth matrix(dpDTM),developed to overcome the limited availability of autologous tooth grafts,has suboptimal pore size and surface roughness.This study aimed to fabricate a surface-modified dpDTM using acid etching and collagen coating,followed by in vitro evaluation of physicochemical and biological properties.The dpDTM was modified into two protocols:Acid-modified dpDTM(A-dpDTM)and collagen-modified dpDTM(C-dpDTM).Results demonstrated that A-dpDTM and C-dpDTM had increased pore sizes and rougher surfaces compared to dpDTM.Collagen immobilization was evidenced by nitrogen presence exclusively in C-dpDTM.All groups had a Ca/P molar ratio of 1.67 and hydroxyapatite as the sole constituent,with 65-67%crystallinity.Degradation rates significantly increased to 30%and 20%for C-dpDTM and A-dpDTM,respectively,compared to 10%for dpDTM after 120 days.Cumulative collagen release of C-dpDTM on Day 30 was 45.16 mg/ml.Osteoblasts attachment and proliferation were enhanced on all scaffolds,especially C-dpDTM,which displayed the highest proliferation and differentiation rates.In conclusion,surface modified of dpDTM,including A-dpDTM and C-dpDTM,significantly enhances bioactivity by altering surface properties and promoting osteoblast activity,thereby demonstrating promise for bone regeneration applications.
基金supported by the National Natural Science Foundation of China under Grant 61603263。
文摘This paper proposes a novel control approach for fault-tolerant control of dual three-phase permanent magnet synchronous motor(PMSM) under one-phase open-circuit fault.A modified six-phase static coordinate transformation matrix and an extended rotating coordinate transformation matrix are investigated considering the influence of the fifth harmonic space on fault-tolerant control. These mathematical models are further analyzed in the fundamental space and the fifth harmonic space after the fault and to eliminate the coupling between the d-q axis voltage equation in the fundamental wave space and the d-q axis voltage equation in the fifth harmonic space, a secondary rotation coordinate transformation matrix is proposed. To achieve the purpose of reducing torque ripple, the fault-tolerant control method proposed in this paper not only takes the minimum copper loss as the constraint condition, but also injects the fifth harmonic current. The experimental result of current and torque is used to verify the accuracy of fault-tolerant control.
文摘This paper presents a new solution to the problem of transmission cost allocation to its users.The proposed technique utilizes modified Z-bus theory,equivalent current injection and impedance of the generators and loads,and is developed by the equal-sharing as well as the orthogonal projection principle.The procedure is performed in three steps.First,the modified Z-bus theory is used to calculate the contribution of the users into the network bus voltages as well as the branch currents.Then,the equal sharing principle is confirmed by the game theory solutions and is subsequently applied to identify the users’contributions into the branch power flows.After that,the orthogonal projections of the contributions are calculated and the concept of effective contributions is suggested.The proposed methodology provides the percentage shares of the users on the network complex variables,which help to better assess the contributions.A 2-bus and the IEEE 30-bus test system are used to validate the proposed technique.Finally,the proposed methodology is applied to the polish 2383-bus system to emphasize its applicability to large practical systems.
文摘In this paper,we propose a new biased estimator namely modified almost unbiased Liu estimator by combining almost unbiased Liu estimator(AULE)andridge estimator(RE)in a linear regression model when multicollinearity presents amongthe independent variables.Necessary and sufficient conditions for the proposed estimator over the ordinary least square estimator,RE,AULE and Liu estimator(LE)in the mean squared error matrix sense are derived,and the optimal biasing parameters are obtained.To illustrate the theoretical findings,a Monte Carlo simulation study is carried out and a numerical example is used.
文摘The modified shear lag model proposed recently was applied to calculate thermal residual stresses and subsequent stress distributions under tensile and compressive loadings. The expressions for the elastic moduli and the yield strengths under tensile and compressive loadings were derived which take account of thermal residual stresses. The asymmetries in the elastic modulus and the yield strength were interpreted using the derived expressions and the obtained results of the stress calculations. The model predictions have exhibited good agreements with the experimental results and also with the other theoretical predictions
文摘In this article,we propose a new biased estimator,namely stochastic restricted modified almost unbiased Liu estimator by combining modified almost unbiased Liu estimator(MAULE)and mixed estimator(ME)when the stochastic restrictions are available and the multicollinearity presents.The conditions of supe-riority of the proposed estimator over the ordinary least square estimator,ME,ridge estimator,Liu estimator,almost unbiased Liu estimator,stochastic restricted Liu esti-mator and MAULE in the mean squared error matrix sense are obtained.Finally,a numerical example and a Monte Carlo simulation are given to illustrate the theoretical findings.
