Manufacturing accuracy, especially position accuracy of fastener holes, directly affects service life and security of aircraft. The traditional modification has poor robustness, while the modification based on laser t...Manufacturing accuracy, especially position accuracy of fastener holes, directly affects service life and security of aircraft. The traditional modification has poor robustness, while the modification based on laser tracker costs too much. To improve the relative position accuracy of aircraft assembly drilling, and ensure the hole-edge distance requirement, a method was presented to modify the coordinates of drilling holes. Based on online inspecting two positions of pre-assembly holes and their theoretical coordinates, the spatial coordinate transformation matrix of modification could be calculated. Thus the straight drilling holes could be modified. The method improves relative position accuracy of drilling on simple structure effectively. And it reduces the requirement of absolute position accuracy and the cost of position modification. And the process technician also can use this method to decide the position accuracy of different pre-assembly holes based on the accuracy requirement of assembly holes.展开更多
Glycation is a non-enzymatic post-translational modification which assigns sugar molecule and residues to a peptide.It is a clinically important attribute to numerous age-related,metabolic,and chronic diseases such as...Glycation is a non-enzymatic post-translational modification which assigns sugar molecule and residues to a peptide.It is a clinically important attribute to numerous age-related,metabolic,and chronic diseases such as diabetes,Alzheimer’s,renal failure,etc.Identification of a non-enzymatic reaction are quite challenging in research.Manual identification in labs is a very costly and timeconsuming process.In this research,we developed an accurate,valid,and a robust model named as Gly-LysPred to differentiate the glycated sites from non-glycated sites.Comprehensive techniques using position relative features are used for feature extraction.An algorithm named as a random forest with some preprocessing techniques and feature engineering techniques was developed to train a computational model.Various types of testing techniques such as self-consistency testing,jackknife testing,and cross-validation testing are used to evaluate the model.The overall model’s accuracy was accomplished through self-consistency,jackknife,and cross-validation testing 100%,99.92%,and 99.88%with MCC 1.00,0.99,and 0.997 respectively.In this regard,a user-friendly webserver is also urbanized to accumulate the whole procedure.These features vectorization methods suggest that they can play a critical role in other web servers which are developed to classify lysine glycation.展开更多
Five-axis ball-end milling is commonly used to machine the complex surfaces. Local tool interference phenomenon which often occurs in five-axis milling should be urgently solved. In this paper, a simplified method to ...Five-axis ball-end milling is commonly used to machine the complex surfaces. Local tool interference phenomenon which often occurs in five-axis milling should be urgently solved. In this paper, a simplified method to detect the occurrence of local tool interference and modify tool position is proposed. First, the detection matrix is established to detect local tool interference at all the cutter location points on tool path simultaneously in five-axis ball-end milling of complex surfaces. The algorithm of detection matrix based on point arithmetic is simple. Secondly, the new coordinates of the modified interfering-free points are obtained precisely by using the genetic algorithm. The feasibility of the method is validated by simulation in Matlab. This research is benefit to simplify the calculation of local tool interference detection and tool position modification.展开更多
Background Judkins catheter is widely used in recent years, for clinical angiography and intervention of most normal coronary arteries, but still incapable to deal with the problems caused by difficult coronary artery...Background Judkins catheter is widely used in recent years, for clinical angiography and intervention of most normal coronary arteries, but still incapable to deal with the problems caused by difficult coronary artery （DCA）. DCA may influence the procedure of diagnosis and intervention of ischemic heart disease （IHD）. To cope with different subtypes of DCA, catheters like Amplatz, EBU, Leya, etc. were born at that moment, but these stan- dard catheters are used just in special cases and have so many sequences that a local hospital may not be able to keep all of them available routinely at any time. To overcome this problem, some centers perform angiography and intervention using modified catheters based on their own condition and have obtained some experiences. Catheter modification techniques used in these years are reviewed, and are stated respectively based on dealing with different subtypes of DCA to provide practical guidance for clinical diagnosis and intervention for IHD patients having DCA.展开更多
文摘Manufacturing accuracy, especially position accuracy of fastener holes, directly affects service life and security of aircraft. The traditional modification has poor robustness, while the modification based on laser tracker costs too much. To improve the relative position accuracy of aircraft assembly drilling, and ensure the hole-edge distance requirement, a method was presented to modify the coordinates of drilling holes. Based on online inspecting two positions of pre-assembly holes and their theoretical coordinates, the spatial coordinate transformation matrix of modification could be calculated. Thus the straight drilling holes could be modified. The method improves relative position accuracy of drilling on simple structure effectively. And it reduces the requirement of absolute position accuracy and the cost of position modification. And the process technician also can use this method to decide the position accuracy of different pre-assembly holes based on the accuracy requirement of assembly holes.
基金the Research Management Center,Xiamen University Malaysia under XMUM Research Program Cycle 4(Grant No.XMUMRF/2019-C4/IECE/0012).
文摘Glycation is a non-enzymatic post-translational modification which assigns sugar molecule and residues to a peptide.It is a clinically important attribute to numerous age-related,metabolic,and chronic diseases such as diabetes,Alzheimer’s,renal failure,etc.Identification of a non-enzymatic reaction are quite challenging in research.Manual identification in labs is a very costly and timeconsuming process.In this research,we developed an accurate,valid,and a robust model named as Gly-LysPred to differentiate the glycated sites from non-glycated sites.Comprehensive techniques using position relative features are used for feature extraction.An algorithm named as a random forest with some preprocessing techniques and feature engineering techniques was developed to train a computational model.Various types of testing techniques such as self-consistency testing,jackknife testing,and cross-validation testing are used to evaluate the model.The overall model’s accuracy was accomplished through self-consistency,jackknife,and cross-validation testing 100%,99.92%,and 99.88%with MCC 1.00,0.99,and 0.997 respectively.In this regard,a user-friendly webserver is also urbanized to accumulate the whole procedure.These features vectorization methods suggest that they can play a critical role in other web servers which are developed to classify lysine glycation.
基金Funded by the National Natural Science Foundation of China (No.51575321)the Major Science and Technology Innovation Project of Shandong Province (No.2018CXGC0804)Taishan Scholars Program of Shandong Province (No.ts201712002)
文摘Five-axis ball-end milling is commonly used to machine the complex surfaces. Local tool interference phenomenon which often occurs in five-axis milling should be urgently solved. In this paper, a simplified method to detect the occurrence of local tool interference and modify tool position is proposed. First, the detection matrix is established to detect local tool interference at all the cutter location points on tool path simultaneously in five-axis ball-end milling of complex surfaces. The algorithm of detection matrix based on point arithmetic is simple. Secondly, the new coordinates of the modified interfering-free points are obtained precisely by using the genetic algorithm. The feasibility of the method is validated by simulation in Matlab. This research is benefit to simplify the calculation of local tool interference detection and tool position modification.
基金supported by National Natural Science Foundation of China(No.81641058)
文摘Background Judkins catheter is widely used in recent years, for clinical angiography and intervention of most normal coronary arteries, but still incapable to deal with the problems caused by difficult coronary artery （DCA）. DCA may influence the procedure of diagnosis and intervention of ischemic heart disease （IHD）. To cope with different subtypes of DCA, catheters like Amplatz, EBU, Leya, etc. were born at that moment, but these stan- dard catheters are used just in special cases and have so many sequences that a local hospital may not be able to keep all of them available routinely at any time. To overcome this problem, some centers perform angiography and intervention using modified catheters based on their own condition and have obtained some experiences. Catheter modification techniques used in these years are reviewed, and are stated respectively based on dealing with different subtypes of DCA to provide practical guidance for clinical diagnosis and intervention for IHD patients having DCA.
