Rheumatoid arthritis（RA） is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A...Rheumatoid arthritis（RA） is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages：（i） triggering,（ii） maturation,（iii） targeting, and（iv） fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies（including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs） remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA.展开更多
Glaciers in China can be categorized into 3 types, i.e. the maritime (temperate) type, sub-continental (sub-polar) type and extreme Continental (polar) type, which take 22%, 46% and 32% of the total existing glacier a...Glaciers in China can be categorized into 3 types, i.e. the maritime (temperate) type, sub-continental (sub-polar) type and extreme Continental (polar) type, which take 22%, 46% and 32% of the total existing glacier area (59 406 km2) respectively. Researches indicate that glaciers of the three types show different response patterns to the global warming. Since the Maxima of the Little Ice Age (the 17th century), air temperature has risen at a magnitude of 1.3℃on average and the glacier area decreased corresponds to 20% of the present total glacier area in western China. it is estimated that air temperature rise in the 2030s, 2070s and 2100s will be of the order of 0.4-1.2, 1.2-2.7 and 2.1-4.0 K in western China. With these scenarios, glaciers in China will suffer from further shrinkage by 12%, 28% and 45% by the 2030s, 2070s and 2100s. The uncertainties may account for 30%-67% in 2100 in China.展开更多
This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern sci...This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern science and technology. The R&D of CTHM is thought to be an important pathway for new drug discovery. Since1949, about 140 approved new drugs have been developed, among which about 80 originated directly or indirectly from medicinal plants. CTHM has gained interest from the international medical, biomedical, and pharmaceutical institutions as a valuable source of potential medicines. For the modernization of CMM and innovative research of CTHM, there are following challenges to be faced: (1) to evaluate the efficacy, pharmacological properties, action mechanism, and active chemical constituents; (2) to develop new methodologies for the quality and safety of CTHM; (3) to apply new '-omics' techniques to accelerate drug discoveries developed from CTHM; and (4) to apply international practices including good agricultural practice, good manufacturing practice, good laboratory practice, and good clinical practice in the R&D of CTHM.展开更多
基金supported in part by the Australian National Health and Medical Research Council (NHMRC, No. 1107828)Arthritis foundation of Australiathe University of Western Australia Research Collaboration Awards
文摘Rheumatoid arthritis（RA） is a chronic systemic autoimmune disease that primarily affects the lining of the synovial joints and is associated with progressive disability, premature death, and socioeconomic burdens. A better understanding of how the pathological mechanisms drive the deterioration of RA progress in individuals is urgently required in order to develop therapies that will effectively treat patients at each stage of the disease progress. Here we dissect the etiology and pathology at specific stages：（i） triggering,（ii） maturation,（iii） targeting, and（iv） fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences. Modern pharmacologic therapies（including conventional, biological, and novel potential small molecule disease-modifying anti-rheumatic drugs） remain the mainstay of RA treatment and there has been significant progress toward achieving disease remission without joint deformity. Despite this, a significant proportion of RA patients do not effectively respond to the current therapies and thus new drugs are urgently required. This review discusses recent advances of our understanding of RA pathogenesis, disease modifying drugs, and provides perspectives on next generation therapeutics for RA.
文摘Glaciers in China can be categorized into 3 types, i.e. the maritime (temperate) type, sub-continental (sub-polar) type and extreme Continental (polar) type, which take 22%, 46% and 32% of the total existing glacier area (59 406 km2) respectively. Researches indicate that glaciers of the three types show different response patterns to the global warming. Since the Maxima of the Little Ice Age (the 17th century), air temperature has risen at a magnitude of 1.3℃on average and the glacier area decreased corresponds to 20% of the present total glacier area in western China. it is estimated that air temperature rise in the 2030s, 2070s and 2100s will be of the order of 0.4-1.2, 1.2-2.7 and 2.1-4.0 K in western China. With these scenarios, glaciers in China will suffer from further shrinkage by 12%, 28% and 45% by the 2030s, 2070s and 2100s. The uncertainties may account for 30%-67% in 2100 in China.
文摘This review is briefly to recall the history of research and development (R&D) of Chinese materia medica (CMM) and to discuss the challenges of Chinese traditional and herbal medicines (CTHM) facing the modern science and technology. The R&D of CTHM is thought to be an important pathway for new drug discovery. Since1949, about 140 approved new drugs have been developed, among which about 80 originated directly or indirectly from medicinal plants. CTHM has gained interest from the international medical, biomedical, and pharmaceutical institutions as a valuable source of potential medicines. For the modernization of CMM and innovative research of CTHM, there are following challenges to be faced: (1) to evaluate the efficacy, pharmacological properties, action mechanism, and active chemical constituents; (2) to develop new methodologies for the quality and safety of CTHM; (3) to apply new '-omics' techniques to accelerate drug discoveries developed from CTHM; and (4) to apply international practices including good agricultural practice, good manufacturing practice, good laboratory practice, and good clinical practice in the R&D of CTHM.
