AIM: To investigate the causes of missed diagnosis of early gastric cancer (EGC) or high-grade intraepithelial neoplasia (HGIN) in Chongqing, China. METHODS: The present study summarizes 103 cases of EGC/HGIN detected...AIM: To investigate the causes of missed diagnosis of early gastric cancer (EGC) or high-grade intraepithelial neoplasia (HGIN) in Chongqing, China. METHODS: The present study summarizes 103 cases of EGC/HGIN detected by esophagogastroduodenos-copy (EGD) and pathological analysis from January 2010 to December 2011. Dimethyl silicone oil was administrated orally 15 min before the EGD procedures. The stomach was cleaned by repeated washing with saline when the gastroscope entered the stomach cavity. Suspected EGC lesions were subject to conventional biopsy sampling and pathological examinations. The correlation between lesion locations, endoscopic morphology of cancerous sites, training level of the examiners, pathological biopsies, and missed diagnosis was analyzed. RESULTS: Twenty-three cases were missed among the 103 cases (22.23%) of EGC/HGIN. The rate of missed EGC in the gastroesophageal junction (8/19, 42.1%) was significantly higher than at other sites (15/84, 17.86%) (χ2 = 5.253, P = 0.022). In contrast, the rate of missed EGC in the lower stomach body (2/14, 14.29%) was lower than at other sites (21/89,23.6%), but there were no significant differences (χ2 = 0.289, P = 0.591). The rate of missed EGC in the gastric antrum (5/33, 15.15%) was lower than at other sites (18/70, 25.71%), but there were no significant differences (χ2 = 1.443, P = 0.230). Endoscopists from less prestigious hospitals were more prone to not diagnosing EGC than those from more prestigious hospitals (χ2 = 4.261, P = 0.039). When the number of biopsies was < 4, the rate of missed diagnosis was higher (20/23, 89.96%) than for when there were > 4 biopsies (3/23, 13.04%) (P < 0.001). In addition, there was no significant difference in the rate of missed diagnosis in patients with 1-3 biopsy specimens (χ2 = 0.141, P = 0.932). CONCLUSION: Endoscopists should have a clear understanding of the anatomical characteristics of the esophagus/stomach, and endoscopic identification of early lesions increases with the number of biopsies.展开更多
目的探讨常规电子结肠镜检查中结肠息肉的漏诊情况,包括漏诊率、漏诊息肉大小、分型、部位和病理状况。方法回顾3年间在120 d 内接受多次结肠镜检查的结肠息肉患者的病例资料,记录患者前2次肠镜检查的息肉数,漏诊息肉数,计算漏诊率。结...目的探讨常规电子结肠镜检查中结肠息肉的漏诊情况,包括漏诊率、漏诊息肉大小、分型、部位和病理状况。方法回顾3年间在120 d 内接受多次结肠镜检查的结肠息肉患者的病例资料,记录患者前2次肠镜检查的息肉数,漏诊息肉数,计算漏诊率。结果符合要求的患者共143例,男92例,女51例,年龄23～82岁;漏诊息肉数共126枚,漏诊率22.5%;在漏诊的息肉中,<5mm、5～9 mm 和≥10 mm 息肉分别占80.2%、18.3%和1.6%,各项间比较差异有统计学意义(P<0.01);山田Ⅰ、Ⅱ、Ⅲ和Ⅳ型息肉分别占87.3%、8.7%、3.2%和0.8%,各项间比较差异有统计学意义(P<0.01);直肠、乙状结肠、降结肠、横结肠、肝曲、升结肠和盲肠分别占11.1%、27.0%、12.7%、19.1%、10.3%、15.1%和4.8%,各项间比较差异有统计学意义(P<0.01);漏诊的晚期腺瘤在漏诊的腺瘤性息肉中占14.8%;漏诊息肉数与基础息肉数间相关分析显示有显著的相关性(r=0.674,P<0.01)。结论常规电子结肠镜检查中结肠息肉有较高的漏诊率,各段结肠间漏诊率不同,且漏诊息肉绝大多数为<5 mm 的Ⅰ型息肉。患者罹患息肉越多,漏诊越多。展开更多
文摘AIM: To investigate the causes of missed diagnosis of early gastric cancer (EGC) or high-grade intraepithelial neoplasia (HGIN) in Chongqing, China. METHODS: The present study summarizes 103 cases of EGC/HGIN detected by esophagogastroduodenos-copy (EGD) and pathological analysis from January 2010 to December 2011. Dimethyl silicone oil was administrated orally 15 min before the EGD procedures. The stomach was cleaned by repeated washing with saline when the gastroscope entered the stomach cavity. Suspected EGC lesions were subject to conventional biopsy sampling and pathological examinations. The correlation between lesion locations, endoscopic morphology of cancerous sites, training level of the examiners, pathological biopsies, and missed diagnosis was analyzed. RESULTS: Twenty-three cases were missed among the 103 cases (22.23%) of EGC/HGIN. The rate of missed EGC in the gastroesophageal junction (8/19, 42.1%) was significantly higher than at other sites (15/84, 17.86%) (χ2 = 5.253, P = 0.022). In contrast, the rate of missed EGC in the lower stomach body (2/14, 14.29%) was lower than at other sites (21/89,23.6%), but there were no significant differences (χ2 = 0.289, P = 0.591). The rate of missed EGC in the gastric antrum (5/33, 15.15%) was lower than at other sites (18/70, 25.71%), but there were no significant differences (χ2 = 1.443, P = 0.230). Endoscopists from less prestigious hospitals were more prone to not diagnosing EGC than those from more prestigious hospitals (χ2 = 4.261, P = 0.039). When the number of biopsies was < 4, the rate of missed diagnosis was higher (20/23, 89.96%) than for when there were > 4 biopsies (3/23, 13.04%) (P < 0.001). In addition, there was no significant difference in the rate of missed diagnosis in patients with 1-3 biopsy specimens (χ2 = 0.141, P = 0.932). CONCLUSION: Endoscopists should have a clear understanding of the anatomical characteristics of the esophagus/stomach, and endoscopic identification of early lesions increases with the number of biopsies.
文摘目的探讨常规电子结肠镜检查中结肠息肉的漏诊情况,包括漏诊率、漏诊息肉大小、分型、部位和病理状况。方法回顾3年间在120 d 内接受多次结肠镜检查的结肠息肉患者的病例资料,记录患者前2次肠镜检查的息肉数,漏诊息肉数,计算漏诊率。结果符合要求的患者共143例,男92例,女51例,年龄23～82岁;漏诊息肉数共126枚,漏诊率22.5%;在漏诊的息肉中,<5mm、5～9 mm 和≥10 mm 息肉分别占80.2%、18.3%和1.6%,各项间比较差异有统计学意义(P<0.01);山田Ⅰ、Ⅱ、Ⅲ和Ⅳ型息肉分别占87.3%、8.7%、3.2%和0.8%,各项间比较差异有统计学意义(P<0.01);直肠、乙状结肠、降结肠、横结肠、肝曲、升结肠和盲肠分别占11.1%、27.0%、12.7%、19.1%、10.3%、15.1%和4.8%,各项间比较差异有统计学意义(P<0.01);漏诊的晚期腺瘤在漏诊的腺瘤性息肉中占14.8%;漏诊息肉数与基础息肉数间相关分析显示有显著的相关性(r=0.674,P<0.01)。结论常规电子结肠镜检查中结肠息肉有较高的漏诊率,各段结肠间漏诊率不同,且漏诊息肉绝大多数为<5 mm 的Ⅰ型息肉。患者罹患息肉越多,漏诊越多。
