BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counselin...BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counseling;however,these methods have different degrees of side effects and limitations.In recent years,nonconvulsive electrotherapy(NET)has attracted increasing attention as a noninvasive treatment method.However,the clinical efficacy and potential mechanism of NET on depression are still unclear.We hypothesized that NET has a positive clinical effect in the treatment of depression,and may have a regulatory effect on serum inflammatory factors during treatment.AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors.METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022,the observation group that received a combination of mindfulness-based stress reduction(MBSR)and NET treatment(n=70)and the control group that only received MBSR therapy(n=70).The clinical effectiveness of the treatment was evaluated by assessing various factors,including the Hamilton Depression Scale(HAMD)-17,self-rating idea of suicide scale(SSIOS),Pittsburgh Sleep Quality Index(PSQI),and levels of serum inflammatory factors before and after 8 wk of treatment.The quality of life scores between the two groups were compared.Comparisons were made using t and χ^(2) tests.RESULTS After 8 wk of treatment,the observation group exhibited a 91.43%overall effectiveness rate which was higher than that of the control group which was 74.29%(64 vs 52,χ^(2)=7.241;P<0.05).The HAMD,SSIOS,and PSQI scores showed a significant decrease in both groups.Moreover,the observation group had lower scores than the control group(10.37±2.04 vs 14.02±2.16,t=10.280;1.67±0.28 vs 0.87±0.12,t=21.970;5.29±1.33 vs 7.94±1.35,t=11.700;P both<0.001).Additionally,there was a notable decrease in the IL-2,IL-1β,and IL-6 in both groups after treatment.Furthermore,the ob展开更多
BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experien...BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients展开更多
The Persian Gulf War of 1990 to 1991 involved the deployment of nearly 700,000 American troops to the Middle East.Deployment-related exposures to toxic substances such as pesticides,nerve agents,pyridostigmine bromide...The Persian Gulf War of 1990 to 1991 involved the deployment of nearly 700,000 American troops to the Middle East.Deployment-related exposures to toxic substances such as pesticides,nerve agents,pyridostigmine bromide(PB),smoke from burning oil wells,and petrochemicals may have contributed to medical illness in as many as 250,000 of those American troops.The cluster of chronic symptoms,now referred to as Gulf War Illness(GWI),has been studied by many researchers over the past two decades.Although over$500 million has been spent on GWI research,to date,no cures or condition-specific treatments have been discovered,and the exact pathophysiology remains elusive.Using the 2007 National Institute of Health(NIH)Roadmap for Medical Research model as a reference framework,we reviewed studies of interventions involving GWI patients to assess the progress of treatment-related GWI research.All GWI clinical trial studies reviewed involved investigations of existing interventions that have shown efficacy in other diseases with analogous symptoms.After reviewing the published and ongoing registered clinical trials for cognitivebehavioral therapy,exercise therapy,acupuncture,coenzyme Q10(CoQ10),mifepristone,and carnosine in GWI patients,we identified only four treatments(cognitive-behavioral therapy,exercise therapy,CoQ10,and mifepristone)that have progressed beyond a phase II trial.We conclude that progress in the scientific study of therapies for GWI has not followed the NIH Roadmap for Medical Research model.Establishment of a standard case definition,prioritized GWI research funding for the characterization of the pathophysiology of the condition,and rapid replication and adaptation of early phase,single site clinical trials could substantially advance research progress and treatment discovery for this condition.展开更多
BACKGROUND Acute pancreatitis(AP)is a common inflammatory disease of the pancreas with high mortality rates.It is of great significance to take scientific intervention measures for patients with AP in time.AIM To expl...BACKGROUND Acute pancreatitis(AP)is a common inflammatory disease of the pancreas with high mortality rates.It is of great significance to take scientific intervention measures for patients with AP in time.AIM To explore the effect of standardized nursing combined with mindfulness stress reduction training on the curative effect,negative emotion,and quality of life in patients with acute pancreatitis.METHODS A total of 80 patients with acute pancreatitis admitted to The First People's Hospital of Jiangxia District Hospital from May 2021 to May 2023 were randomly divided into control group and observation group(n=40).Patients in control group were given the standardized nursing intervention,and the observation group were given standardized nursing plus mindfulness stress reduction training intervention.The time of clinical symptom disappeared or improved,complication occurrence rate,emotional state,and quality of life score of the two groups were observed and compared.RESULTS In comparison with the control group,the bowel sound recovery time,ventosity and abdominal pain improvement time,and venting and cacation time in observation group were shorter,and the total incidence rate of complications was reduced,showing statistically significant difference(P<0.05).The scores of anxiety and depression in observation group were lower than those in control group(P<0.05).Serum levels of tumour necrosis factor alpha,interleukin(IL)-6,IL-1βand IL-8 in observation group were lower than those in control group(P<0.05).The scores of life quality in physiology,psychology,environment and social relations in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).CONCLUSION The application of standardized nursing intervention combined with mindfulness stress reduction training in patients with acute pancreatitis has a definite effect,which can help to ameliorate the clinical symptoms,anxiety and depression of patients,reduce the incidence rate of complications,and improve展开更多
Mindfulness-based cognitive therapy(MBCT)is frequently used for psychiatric disorders.Despite MBCT’s considerable potential for improving psychological health for patients,there is little empirical evidence to suppor...Mindfulness-based cognitive therapy(MBCT)is frequently used for psychiatric disorders.Despite MBCT’s considerable potential for improving psychological health for patients,there is little empirical evidence to support its practical application in Chinese.This review will define meditation and mindfulness,provide an overview of the development of MBCT,identify the evidence for the effectiveness of MBCT,and offer recommendations to medical personnels on how to provide support for patients receiving mindfulness intervention.展开更多
Objective:This study aimed to evaluate the effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis.Methods:CNKI,VIP,WanFang,CBM,Embase,the Cochrane Lib...Objective:This study aimed to evaluate the effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis.Methods:CNKI,VIP,WanFang,CBM,Embase,the Cochrane Library and PubMed databases were retrieved.Randomized controlled trials of intervention effects of mindfulness-based stress reduction combined with conventional hemodialysis education compared with conventional hemodialysis education on maintenance hemodialysis patients were collected.The retrieval period was from the establishment of the database to December 2019.Two researchers independently screened the literatures,extracted the data and evaluated the risk of bias in the included studies.RevMan 5.3 software was used for analysis.Results:A total of 9 studies,which comprised a total of 664 participants were included in the final meta analysis.The results showed that mindfulness-based stress reduction could reduce the anxiety of patients(SMD=?1.65,95%CI:?2.29 to?1.01),reduce the depression(SMD=?1.44,95%CI:?1.85 to?1.03).Conclusion:Mindfulness-based stress reduction therapy has positive effects on depression,anxiety in patients with maintenance hemodialysis.展开更多
Objective:To systematically evaluate the effects of MBSR on psychological health intervention in nurses.Methods:The randomized controlled trial(RCT)and self-controlled trial(SC)investigating the application of mindful...Objective:To systematically evaluate the effects of MBSR on psychological health intervention in nurses.Methods:The randomized controlled trial(RCT)and self-controlled trial(SC)investigating the application of mindfulness-based stress reduction in nursing staff were retrieved from CNKI,WanFang,VIP,PubMed,Cochrane Library,Web of Science,EMBASE databases.The retrieval time was set from the establishment of the database to April 2020.The Review Manager 5.3 software were used for meta-analysis.Result:9 RCTs and 5 self-control trails were included with 1421,712 subjects in the experimental group and 709 subjects in the control group.The results of the meta-analysis showed that compared with the control group,mindfulness-based stress reduction therapy can effectively reduce the psychological symptoms of clinical nurses[SMD=-0.96,95%CI(-1.51,-0.38),P=0.001],reduces nurses'anxiety levels[SMD=-1.28,95%CI(-2.18,-0.38),P=0.005],relieve the nurse's depression[SMD=-1.08,95%CI(-2.15,-0.02),P=0.005],improve the mental resilience of nurse[SMD=7.05,95%CI(3.93,10.17),P=0.03],showing a statistical meaning.Conclusion:The mental health of nurses is often neglected by themselves and there is insufficient awareness that MBSR can improve mental health.There has been a debate about whether MBSR actually improves the mental health of nurses,so it is necessary to further explore this issue and seek better methods and opportunities for practice.展开更多
基金Supported by Guangdong Provincial Medical Scientific Research Fund Project,No.B2016109.
文摘BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counseling;however,these methods have different degrees of side effects and limitations.In recent years,nonconvulsive electrotherapy(NET)has attracted increasing attention as a noninvasive treatment method.However,the clinical efficacy and potential mechanism of NET on depression are still unclear.We hypothesized that NET has a positive clinical effect in the treatment of depression,and may have a regulatory effect on serum inflammatory factors during treatment.AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors.METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022,the observation group that received a combination of mindfulness-based stress reduction(MBSR)and NET treatment(n=70)and the control group that only received MBSR therapy(n=70).The clinical effectiveness of the treatment was evaluated by assessing various factors,including the Hamilton Depression Scale(HAMD)-17,self-rating idea of suicide scale(SSIOS),Pittsburgh Sleep Quality Index(PSQI),and levels of serum inflammatory factors before and after 8 wk of treatment.The quality of life scores between the two groups were compared.Comparisons were made using t and χ^(2) tests.RESULTS After 8 wk of treatment,the observation group exhibited a 91.43%overall effectiveness rate which was higher than that of the control group which was 74.29%(64 vs 52,χ^(2)=7.241;P<0.05).The HAMD,SSIOS,and PSQI scores showed a significant decrease in both groups.Moreover,the observation group had lower scores than the control group(10.37±2.04 vs 14.02±2.16,t=10.280;1.67±0.28 vs 0.87±0.12,t=21.970;5.29±1.33 vs 7.94±1.35,t=11.700;P both<0.001).Additionally,there was a notable decrease in the IL-2,IL-1β,and IL-6 in both groups after treatment.Furthermore,the ob
基金Supported by Zhangjiakou Science and Technology Plan Project,No.2021127HScientific Research Program Project of Hebei Provincial Administration of Traditional Chinese Medicine,No.2022146.
文摘BACKGROUND Conventional chemotherapy(CC)administered to patients with non-small cell lung cancer(NSCLC)often causes adverse effects,such as cardiopulmonary dysfunction and immune system imbalance.Patients may experience anxiety and depression during the perioperative period due to various factors,such as treatment costs and cancer recurrence risks,thereby compromising the overall quality of life.Consequently,we hypothesized that integrating mindfulness-based stress reduction training(MSRT)with Jinshui Liujun decoction may mitigate negative emotions and promote recovery in patients with NSCLC.AIM To explore the effects of MSRT and Jinshui Liujun decoction on the immune function and emotional state of NSCLC patients.METHODS A retrospective clinical study was conducted involving 92 patients with stage IIIb-IV NSCLC;35 patients in the control group(CG)received CC therapy(combination of pemetrexed and carboplatin),and 57 patients in the treatment group(TG)received MSRT-assisted flavored Jinshui Liujun decoction(FJLD)in addition to CC.We evaluated the survival time,Karnofsky performance status,treatment efficacy,traditional Chinese medicine syndrome score,immune function,negative emotional level,and adverse reactions of the CG and TG.RESULTS Median progression-free survival,Karnofsky performance status,and clinical efficacy of the TG were superior to those of the CG(P<0.05).Symptoms of cough,weakness,bloody sputum,shortness of breath,and chest pain significantly decreased in the TG compared to that in the CG(P<0.05).In the TG,MSRT+FJLD treatment increased the numbers of CD3^(+)and CD4^(+)immune cells,effectively reduced the number of CD8^(+)cells,and enhanced the CD4^(+)/CD8^(+)ratio,thereby restoring the immune function of patients.In the TG,the self-rating anxiety scale and self-rating depression scale scores decreased significantly.There was no statistically significant difference in the incidence of adverse reactions between the CG and TG(P>0.05).CONCLUSION MSRT+FJLD proved to be an effective treatment for patients
文摘The Persian Gulf War of 1990 to 1991 involved the deployment of nearly 700,000 American troops to the Middle East.Deployment-related exposures to toxic substances such as pesticides,nerve agents,pyridostigmine bromide(PB),smoke from burning oil wells,and petrochemicals may have contributed to medical illness in as many as 250,000 of those American troops.The cluster of chronic symptoms,now referred to as Gulf War Illness(GWI),has been studied by many researchers over the past two decades.Although over$500 million has been spent on GWI research,to date,no cures or condition-specific treatments have been discovered,and the exact pathophysiology remains elusive.Using the 2007 National Institute of Health(NIH)Roadmap for Medical Research model as a reference framework,we reviewed studies of interventions involving GWI patients to assess the progress of treatment-related GWI research.All GWI clinical trial studies reviewed involved investigations of existing interventions that have shown efficacy in other diseases with analogous symptoms.After reviewing the published and ongoing registered clinical trials for cognitivebehavioral therapy,exercise therapy,acupuncture,coenzyme Q10(CoQ10),mifepristone,and carnosine in GWI patients,we identified only four treatments(cognitive-behavioral therapy,exercise therapy,CoQ10,and mifepristone)that have progressed beyond a phase II trial.We conclude that progress in the scientific study of therapies for GWI has not followed the NIH Roadmap for Medical Research model.Establishment of a standard case definition,prioritized GWI research funding for the characterization of the pathophysiology of the condition,and rapid replication and adaptation of early phase,single site clinical trials could substantially advance research progress and treatment discovery for this condition.
文摘BACKGROUND Acute pancreatitis(AP)is a common inflammatory disease of the pancreas with high mortality rates.It is of great significance to take scientific intervention measures for patients with AP in time.AIM To explore the effect of standardized nursing combined with mindfulness stress reduction training on the curative effect,negative emotion,and quality of life in patients with acute pancreatitis.METHODS A total of 80 patients with acute pancreatitis admitted to The First People's Hospital of Jiangxia District Hospital from May 2021 to May 2023 were randomly divided into control group and observation group(n=40).Patients in control group were given the standardized nursing intervention,and the observation group were given standardized nursing plus mindfulness stress reduction training intervention.The time of clinical symptom disappeared or improved,complication occurrence rate,emotional state,and quality of life score of the two groups were observed and compared.RESULTS In comparison with the control group,the bowel sound recovery time,ventosity and abdominal pain improvement time,and venting and cacation time in observation group were shorter,and the total incidence rate of complications was reduced,showing statistically significant difference(P<0.05).The scores of anxiety and depression in observation group were lower than those in control group(P<0.05).Serum levels of tumour necrosis factor alpha,interleukin(IL)-6,IL-1βand IL-8 in observation group were lower than those in control group(P<0.05).The scores of life quality in physiology,psychology,environment and social relations in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).CONCLUSION The application of standardized nursing intervention combined with mindfulness stress reduction training in patients with acute pancreatitis has a definite effect,which can help to ameliorate the clinical symptoms,anxiety and depression of patients,reduce the incidence rate of complications,and improve
基金This work was funded by the Chia Family Foundation Health Fellowship Program which funded by the Yale-China Association(2013-2015).
文摘Mindfulness-based cognitive therapy(MBCT)is frequently used for psychiatric disorders.Despite MBCT’s considerable potential for improving psychological health for patients,there is little empirical evidence to support its practical application in Chinese.This review will define meditation and mindfulness,provide an overview of the development of MBCT,identify the evidence for the effectiveness of MBCT,and offer recommendations to medical personnels on how to provide support for patients receiving mindfulness intervention.
文摘Objective:This study aimed to evaluate the effects of mindfulness-based stress reduction therapy on anxiety and depression in patients with maintenance hemodialysis.Methods:CNKI,VIP,WanFang,CBM,Embase,the Cochrane Library and PubMed databases were retrieved.Randomized controlled trials of intervention effects of mindfulness-based stress reduction combined with conventional hemodialysis education compared with conventional hemodialysis education on maintenance hemodialysis patients were collected.The retrieval period was from the establishment of the database to December 2019.Two researchers independently screened the literatures,extracted the data and evaluated the risk of bias in the included studies.RevMan 5.3 software was used for analysis.Results:A total of 9 studies,which comprised a total of 664 participants were included in the final meta analysis.The results showed that mindfulness-based stress reduction could reduce the anxiety of patients(SMD=?1.65,95%CI:?2.29 to?1.01),reduce the depression(SMD=?1.44,95%CI:?1.85 to?1.03).Conclusion:Mindfulness-based stress reduction therapy has positive effects on depression,anxiety in patients with maintenance hemodialysis.
文摘Objective:To systematically evaluate the effects of MBSR on psychological health intervention in nurses.Methods:The randomized controlled trial(RCT)and self-controlled trial(SC)investigating the application of mindfulness-based stress reduction in nursing staff were retrieved from CNKI,WanFang,VIP,PubMed,Cochrane Library,Web of Science,EMBASE databases.The retrieval time was set from the establishment of the database to April 2020.The Review Manager 5.3 software were used for meta-analysis.Result:9 RCTs and 5 self-control trails were included with 1421,712 subjects in the experimental group and 709 subjects in the control group.The results of the meta-analysis showed that compared with the control group,mindfulness-based stress reduction therapy can effectively reduce the psychological symptoms of clinical nurses[SMD=-0.96,95%CI(-1.51,-0.38),P=0.001],reduces nurses'anxiety levels[SMD=-1.28,95%CI(-2.18,-0.38),P=0.005],relieve the nurse's depression[SMD=-1.08,95%CI(-2.15,-0.02),P=0.005],improve the mental resilience of nurse[SMD=7.05,95%CI(3.93,10.17),P=0.03],showing a statistical meaning.Conclusion:The mental health of nurses is often neglected by themselves and there is insufficient awareness that MBSR can improve mental health.There has been a debate about whether MBSR actually improves the mental health of nurses,so it is necessary to further explore this issue and seek better methods and opportunities for practice.
