目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)结合正念激励对酒精依赖戒断综合征患者负面情绪的影响。方法选取2020年3月至2021年3月丽水市第二人民医院收治的128例酒精依赖戒断综合征患者,按照随机数...目的探讨重复经颅磁刺激(repetitive transcranial magnetic stimulation,rTMS)结合正念激励对酒精依赖戒断综合征患者负面情绪的影响。方法选取2020年3月至2021年3月丽水市第二人民医院收治的128例酒精依赖戒断综合征患者,按照随机数字表法将其分为A、B、C、D四组,每组各32例。A组患者给予常规药物干预,B组、C组患者在A组干预基础上分别给予rTMS干预和正念激励干预,D组患者在A组基础上给予rTMS结合正念激励干预。比较四组患者干预前后的改良临床机构酒精依赖戒断评估表(revised clinical institute withdrawal assessment for alcohol,CIWA-Ar)评分、宾夕法尼亚酒精渴求量表(Penn alcohol craving scale,PACS)评分、汉密尔顿抑郁量表(Hamilton depressive scale,HAMD)评分、汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分及复饮率、再住院率和满意度。结果干预后,四组患者的CIWA-Ar、PACS、HAMD、HAMA评分均显著低于本组干预前(P<0.05),且B、C、D组患者的上述评分均显著低于A组(P<0.05),D组患者的上述评分均显著低于B、C组(P<0.05)。D组患者的复饮率和再住院率均显著低于A组,满意度显著高于A组(P<0.05)。结论常规药物结合rTMS与正念激励干预,可有效改善酒精依赖戒断综合征患者的戒断反应和对酒精的渴求,减轻负面情绪,降低复饮率和再住院率。展开更多
Background:Parkinson’s Disease(PD)with mild cognitive impairment(MCI)(PD-MCI)represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia.Although ...Background:Parkinson’s Disease(PD)with mild cognitive impairment(MCI)(PD-MCI)represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia.Although transcranial direct current stimulation(tDCS)has been demonstrated to improve motor and non-motor symptoms in PD,to date,no study has investigated the effects of tDCS on Theory of Mind(ToM),i.e.,the ability to understand and predict other people’s behaviours,in PD-MCI.Methods:In this randomized,double-blind,sham-controlled study,we applied active tDCS over the medial frontal cortex(MFC)to modulate ToM performance in twenty patients with PD-MCI.Twenty matched healthy controls(HC)were also enrolled and were asked to perform the ToM task without receiving tDCS.Results:In the patients with PD-MCI,i)ToM performance was worse than that in the HC,ii)ToM abilities were poorer in those with fronto-executive difficulties,and iii)tDCS over the MFC led to significant shortening of latency for ToM tasks.Conclusions:We show for the first time that active tDCS over the MFC enhances ToM in patients with PD-MCI,and suggest that non-invasive brain stimulation could be used to ameliorate ToM deficits observed in these patients.展开更多
目的探讨意拳训练时接受振动刺激对下肢肌肉及其神经支配的影响。方法 48位健康大学生分为3组:意拳振动组(YQV)、意拳组(YQ)以及控制组(CON),进行为期8周、每周3次的训练。训练前后以Biodex System 4等速训练系统、Biopac多导生理记录仪...目的探讨意拳训练时接受振动刺激对下肢肌肉及其神经支配的影响。方法 48位健康大学生分为3组:意拳振动组(YQV)、意拳组(YQ)以及控制组(CON),进行为期8周、每周3次的训练。训练前后以Biodex System 4等速训练系统、Biopac多导生理记录仪及AMTI三维测力台,测试下肢最大等长肌力、等速肌力、肌电反应及静态平衡。统计分析以双因素方差分析进行。结果意拳组的60°/s等速向心肌力显著进步11.8%(P<0.05);静态平衡时,足底压力中心移动面积显著减少15.3%(P<0.05),并明显少于控制组(P<0.05);意拳组在静态平衡的进步率(9.3%)显著优于控制组(P<0.05),其余测试项则无差异;控制组在各因变量中无显著变化。结论意拳结合振动刺激进行训练能有效增进膝伸肌等速肌力与下肢静态平衡的表现,可作为促进下肢肌肉及神经支配表现的新式训练方法。展开更多
基金Mauro Adenzato was supported by the University of Turin(Ricerca scientifica finanziata dall’Università“Cognizione sociale e attaccamento in popolazioni cliniche e non cliniche”)Ivan Enrici was supported by University of Turin grants(Ricerca scientifica finanziata dall’Università“Linea Generale”and“Linea Giovani”).
文摘Background:Parkinson’s Disease(PD)with mild cognitive impairment(MCI)(PD-MCI)represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia.Although transcranial direct current stimulation(tDCS)has been demonstrated to improve motor and non-motor symptoms in PD,to date,no study has investigated the effects of tDCS on Theory of Mind(ToM),i.e.,the ability to understand and predict other people’s behaviours,in PD-MCI.Methods:In this randomized,double-blind,sham-controlled study,we applied active tDCS over the medial frontal cortex(MFC)to modulate ToM performance in twenty patients with PD-MCI.Twenty matched healthy controls(HC)were also enrolled and were asked to perform the ToM task without receiving tDCS.Results:In the patients with PD-MCI,i)ToM performance was worse than that in the HC,ii)ToM abilities were poorer in those with fronto-executive difficulties,and iii)tDCS over the MFC led to significant shortening of latency for ToM tasks.Conclusions:We show for the first time that active tDCS over the MFC enhances ToM in patients with PD-MCI,and suggest that non-invasive brain stimulation could be used to ameliorate ToM deficits observed in these patients.
文摘目的探讨意拳训练时接受振动刺激对下肢肌肉及其神经支配的影响。方法 48位健康大学生分为3组:意拳振动组(YQV)、意拳组(YQ)以及控制组(CON),进行为期8周、每周3次的训练。训练前后以Biodex System 4等速训练系统、Biopac多导生理记录仪及AMTI三维测力台,测试下肢最大等长肌力、等速肌力、肌电反应及静态平衡。统计分析以双因素方差分析进行。结果意拳组的60°/s等速向心肌力显著进步11.8%(P<0.05);静态平衡时,足底压力中心移动面积显著减少15.3%(P<0.05),并明显少于控制组(P<0.05);意拳组在静态平衡的进步率(9.3%)显著优于控制组(P<0.05),其余测试项则无差异;控制组在各因变量中无显著变化。结论意拳结合振动刺激进行训练能有效增进膝伸肌等速肌力与下肢静态平衡的表现,可作为促进下肢肌肉及神经支配表现的新式训练方法。
