Poly（9-phenyl-2,4,8,10-tetraoxaspiro-[5,5]undcane-3-one） （PPTC） was synthesized by the microwave-assisted ring-opening polymerization （MROP） of a six-membered cyclic carbonate monomer 9-phenyl-2,4,8,10-tetraoxas...Poly（9-phenyl-2,4,8,10-tetraoxaspiro-[5,5]undcane-3-one） （PPTC） was synthesized by the microwave-assisted ring-opening polymerization （MROP） of a six-membered cyclic carbonate monomer 9-phenyl-2,4,8,10-tetraoxaspiro- [5,5]undcane-3-one （PTC） with tin（Ⅱ） 2-ethylhexanoate （Sn（Oct）2） or aluminum isopropoxide （Al（OiPr）3） as the catalysts. The obtained polycarbonates were further reduced by apalladium/carbonate catalyst （10% Pd/C） to afford partly deprotected polycarbonates containing hydroxyl groups （HPPTC）. These two types of polycarbonates were characterized by ^1H-NMR, Fourier transform infrared spectroscopy （FTIR）, UV, gel permeation chromatography （GPC）, differential scanning calorimetry （DSC）, and automatic contact-angle measurements. The influence of the feed molar ratio of monomer-to-catalyst, the microwave irradiation power and the reaction time on the polymerization was also studied. The experimental results showed that HPPTC possessed significantly higher hydrophilicity and water absorption rate than PPTC.展开更多
Objective:To prepare a novel biodegradable poly(2-hydroxyethylmethacrilate)(pHEMAt hydrogel as tissue engineering scaffold.Methods:The pHEMA hydrogel was synthesized by microwaveassisted polymerization using 2-hydroxy...Objective:To prepare a novel biodegradable poly(2-hydroxyethylmethacrilate)(pHEMAt hydrogel as tissue engineering scaffold.Methods:The pHEMA hydrogel was synthesized by microwaveassisted polymerization using 2-hydroxyethyl methacrylale(IIEMA)as the raw material,potassium persulfate as the initiator,and PCI.X as the cross-linking additive.The hvdrogels was characterized with FTIR and NMR spectroscopy.The physical and chemical properties of the prepared hydrogel were evaluated,and its degradation performance was tested.The cytotoxicity of the optimum composite hydrogel was measured by an MTT assay to confirm the feasibility of its use in tissue engineering.Results:The optimum conditions under which the hydrogel was prepared by microwave-assisted polymerization are as follows:1.5 g cross-linking additive,0.3 g initiator,reaction temperature of 80°C,and microwave power of 800 W.Degradation studies showed good degradation profiles with 75%in 17 days.Additionally,the hydrogels did not elicit any cytotoxic response in in vitro cytotoxic assays.Conclusion:A biodegradable pIIEMA hydrogel was successfully prepared by microwave-assisted polymerization,as confirmed from FTIR and NMR results.The hydrogel shows promising applications in tissue engineering,and its healing ability and biocompatibilily will be evaluated in detail in the future.展开更多
A series of polycarbonate copolymers were synthesized by microwave-assisted ring-opening polymerization of ε-caprolactone (CL) and 2-phenyl-5,5-bis(oxymethyl) trimethylene carbonate (PTC) with Tin (II) 2-ethylhexanoa...A series of polycarbonate copolymers were synthesized by microwave-assisted ring-opening polymerization of ε-caprolactone (CL) and 2-phenyl-5,5-bis(oxymethyl) trimethylene carbonate (PTC) with Tin (II) 2-ethylhexanoate as a catalyst. These copolymers obtained were detected by 1H NMR, FT-IR, UV, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and automatic contact angle meter. The influences of the feed molar ratio of monomers, catalyst concentration, reaction time and reaction temperature, as well as microwave irradiation power on the copolymerization process were also studied. In vitro degradation tests indicated that these polycarbonate copolymers possess the slow degradation rates and strong hydrophobicity. In vitro release profiles of 5-Fu from copolymers showed that copolymers have the steady drug release rates and good controlled release properties.展开更多
Poly (lactic acid) (PLA) was synthesized by microwave-assisted ring-opening polymerization of D, L-lactide with stannous octanoate (SnOct(2)) as catalyst. Its weight-average molar mass (M-w) ranged from 39000 to 67000...Poly (lactic acid) (PLA) was synthesized by microwave-assisted ring-opening polymerization of D, L-lactide with stannous octanoate (SnOct(2)) as catalyst. Its weight-average molar mass (M-w) ranged from 39000 to 67000 and the polydispersity index from 1.3 to 1.7. The polymerization rate was much faster than that of the conventional thermal polymerization. A degradation of newly formed PLA in reaction mixture by microwave irradiation was observed.展开更多
基金financially supported by the National Natural Science Foundation of China(Nos.51373128 and 51173140)Key National Research and Development Program(No.2016YFB1101302)+4 种基金Wuhan Science and Technology Innovation Team of Hi-tech Industrial Project,Hubei Province(No.2015070504020217)Wuhan Scientific and Technological Project(No.2013010501010131)University Students’ President Funded Project,Wuhan Institute of Technology(No.2015004)“E+” double-major programInnovation Fund for post-graduate education(Nos.CX2014058 and CX2015007),Wuhan Institute of Technology,China
文摘Poly（9-phenyl-2,4,8,10-tetraoxaspiro-[5,5]undcane-3-one） （PPTC） was synthesized by the microwave-assisted ring-opening polymerization （MROP） of a six-membered cyclic carbonate monomer 9-phenyl-2,4,8,10-tetraoxaspiro- [5,5]undcane-3-one （PTC） with tin（Ⅱ） 2-ethylhexanoate （Sn（Oct）2） or aluminum isopropoxide （Al（OiPr）3） as the catalysts. The obtained polycarbonates were further reduced by apalladium/carbonate catalyst （10% Pd/C） to afford partly deprotected polycarbonates containing hydroxyl groups （HPPTC）. These two types of polycarbonates were characterized by ^1H-NMR, Fourier transform infrared spectroscopy （FTIR）, UV, gel permeation chromatography （GPC）, differential scanning calorimetry （DSC）, and automatic contact-angle measurements. The influence of the feed molar ratio of monomer-to-catalyst, the microwave irradiation power and the reaction time on the polymerization was also studied. The experimental results showed that HPPTC possessed significantly higher hydrophilicity and water absorption rate than PPTC.
基金supported by the National Natural Science Foundation of Hainan Province(Grant No.812200)
文摘Objective:To prepare a novel biodegradable poly(2-hydroxyethylmethacrilate)(pHEMAt hydrogel as tissue engineering scaffold.Methods:The pHEMA hydrogel was synthesized by microwaveassisted polymerization using 2-hydroxyethyl methacrylale(IIEMA)as the raw material,potassium persulfate as the initiator,and PCI.X as the cross-linking additive.The hvdrogels was characterized with FTIR and NMR spectroscopy.The physical and chemical properties of the prepared hydrogel were evaluated,and its degradation performance was tested.The cytotoxicity of the optimum composite hydrogel was measured by an MTT assay to confirm the feasibility of its use in tissue engineering.Results:The optimum conditions under which the hydrogel was prepared by microwave-assisted polymerization are as follows:1.5 g cross-linking additive,0.3 g initiator,reaction temperature of 80°C,and microwave power of 800 W.Degradation studies showed good degradation profiles with 75%in 17 days.Additionally,the hydrogels did not elicit any cytotoxic response in in vitro cytotoxic assays.Conclusion:A biodegradable pIIEMA hydrogel was successfully prepared by microwave-assisted polymerization,as confirmed from FTIR and NMR results.The hydrogel shows promising applications in tissue engineering,and its healing ability and biocompatibilily will be evaluated in detail in the future.
基金Supported by the National Natural Science Foundation of China (Grant No.50773060)Hi-Tech Research and Development Program of China (Grant No. 2007AA0218-09)+4 种基金New Century Excellent Talents in University, Ministry of Education of China (Grant No.[2007]70:NCET-07-0649)Scientific Research Foundation for the Returned Overseas Chinese Scholars,Ministry of Education of China (Grant No.[2007]1108)Hubei Provincial International Project for Science and Technology Cooperation (Grant No.2007CA015)Hubei Provincial Key Technologies Research and Development Program (Grant No. 2007AA301B24)Youth Chenguang Project of Science and Technology of Wuhan City, China (Grant No.200750731257)
文摘A series of polycarbonate copolymers were synthesized by microwave-assisted ring-opening polymerization of ε-caprolactone (CL) and 2-phenyl-5,5-bis(oxymethyl) trimethylene carbonate (PTC) with Tin (II) 2-ethylhexanoate as a catalyst. These copolymers obtained were detected by 1H NMR, FT-IR, UV, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and automatic contact angle meter. The influences of the feed molar ratio of monomers, catalyst concentration, reaction time and reaction temperature, as well as microwave irradiation power on the copolymerization process were also studied. In vitro degradation tests indicated that these polycarbonate copolymers possess the slow degradation rates and strong hydrophobicity. In vitro release profiles of 5-Fu from copolymers showed that copolymers have the steady drug release rates and good controlled release properties.
文摘Poly (lactic acid) (PLA) was synthesized by microwave-assisted ring-opening polymerization of D, L-lactide with stannous octanoate (SnOct(2)) as catalyst. Its weight-average molar mass (M-w) ranged from 39000 to 67000 and the polydispersity index from 1.3 to 1.7. The polymerization rate was much faster than that of the conventional thermal polymerization. A degradation of newly formed PLA in reaction mixture by microwave irradiation was observed.
