目的评价牙科用派丽奥软膏对中度和中重度牙周炎患者的疗效,并与牙周临床常用药物“牙康”(甲硝唑)进行比较。方法口腔临床38例中度和中重度成人牙周炎患者被纳入,并随机分为派丽奥试验组和牙康对照组,将派丽奥软膏缓缓注入牙周袋内,给...目的评价牙科用派丽奥软膏对中度和中重度牙周炎患者的疗效,并与牙周临床常用药物“牙康”(甲硝唑)进行比较。方法口腔临床38例中度和中重度成人牙周炎患者被纳入,并随机分为派丽奥试验组和牙康对照组,将派丽奥软膏缓缓注入牙周袋内,给药量约0.05 m l。每周给1次药,共给药2次。采用厌氧培养方法测定用药前后牙周袋内病原菌的变化。结果派丽奥软膏对牙周袋内病原菌有很好的抗菌作用,其有效率为90%;对梭杆菌、消化链球菌、优杆菌、产黑色素的革兰阴性厌氧杆菌如牙龈卟啉单胞菌、中间普氏菌等牙周主要病原菌有明显的抗菌作用(P<0.05)。结论派丽奥软膏与牙康比较抗菌作用差异无显著性(P>0.05).展开更多
Radio-and chemo-sensitizing effects of a new sensitizer, metronidazol amino acidum natrium (CMNa), were studied by the methods of cell surviving fraction (in viiro), tumor growth delay (in vivo) and clinical observati...Radio-and chemo-sensitizing effects of a new sensitizer, metronidazol amino acidum natrium (CMNa), were studied by the methods of cell surviving fraction (in viiro), tumor growth delay (in vivo) and clinical observation. When the hypoxic V79 cells were exposed to γ-ray and CMNa, the cell surviving fraction decreased markedly as compared with radiation alone. The sensitizer enhancement ratio (SER) value was 1. 26-2. 32. When the mice bearing Lewis . B16 melanoma or EMT6 tumors were treated with single dose or fractionated radiation (with or without CMNa) or with antitumor agents (with or without CMNa) the tumor increasing velocity slowed down and the days of tumor growth delay increased significantly when CMNa was given simultaneously.In 96 cases of lung cancer and 80 cases of esophageal cancer patients treated with routine chemotherapy or radiotherapy combined with CMNa, the percentage of CR+PR increased significantly. These results showed that CMNa may be an effective radio- and chemo-sensitizer.展开更多
文摘目的评价牙科用派丽奥软膏对中度和中重度牙周炎患者的疗效,并与牙周临床常用药物“牙康”(甲硝唑)进行比较。方法口腔临床38例中度和中重度成人牙周炎患者被纳入,并随机分为派丽奥试验组和牙康对照组,将派丽奥软膏缓缓注入牙周袋内,给药量约0.05 m l。每周给1次药,共给药2次。采用厌氧培养方法测定用药前后牙周袋内病原菌的变化。结果派丽奥软膏对牙周袋内病原菌有很好的抗菌作用,其有效率为90%;对梭杆菌、消化链球菌、优杆菌、产黑色素的革兰阴性厌氧杆菌如牙龈卟啉单胞菌、中间普氏菌等牙周主要病原菌有明显的抗菌作用(P<0.05)。结论派丽奥软膏与牙康比较抗菌作用差异无显著性(P>0.05).
文摘Radio-and chemo-sensitizing effects of a new sensitizer, metronidazol amino acidum natrium (CMNa), were studied by the methods of cell surviving fraction (in viiro), tumor growth delay (in vivo) and clinical observation. When the hypoxic V79 cells were exposed to γ-ray and CMNa, the cell surviving fraction decreased markedly as compared with radiation alone. The sensitizer enhancement ratio (SER) value was 1. 26-2. 32. When the mice bearing Lewis . B16 melanoma or EMT6 tumors were treated with single dose or fractionated radiation (with or without CMNa) or with antitumor agents (with or without CMNa) the tumor increasing velocity slowed down and the days of tumor growth delay increased significantly when CMNa was given simultaneously.In 96 cases of lung cancer and 80 cases of esophageal cancer patients treated with routine chemotherapy or radiotherapy combined with CMNa, the percentage of CR+PR increased significantly. These results showed that CMNa may be an effective radio- and chemo-sensitizer.
