To investigate the influence of mesopores towards the solidification of self-microemulsifying drug delivery system(SMEDDS), mesoporous silica nanospheres(MSNs) and Santa Barbara Amorphous-15(SBA-15) were compared. The...To investigate the influence of mesopores towards the solidification of self-microemulsifying drug delivery system(SMEDDS), mesoporous silica nanospheres(MSNs) and Santa Barbara Amorphous-15(SBA-15) were compared. The MSNs had hydrodynamic size of 195.35 ± 5.82 nm, and pore diameter of 2.70 nm. The SBA-15 had hydrodynamic size of 2312.19 ± 106.93 nm, and pore diameter of 10.91 nm. The MSNs and SBA-15 showed similar loading efficiency of SMEDDS containing sirolimus(SRL). However,MSNs had higher drug dissolution and in vivo absorption, with relative bioavailability of 174.62%. Thus,the length of mesopores played a more important role in solidification of SMEDDS as compared with the pore diameter. This study suggests that the SMEDDS-MSNs can be a potential candidate for oral administration of hydrophobic drugs.展开更多
Fragrances are widely used in our daily life and have made great contributions to creating a clean and fresh healthy air environment. However, the rapid volatilization severely influences their storage,application and...Fragrances are widely used in our daily life and have made great contributions to creating a clean and fresh healthy air environment. However, the rapid volatilization severely influences their storage,application and quality. Therefore, it is necessary and urgent to develop approaches to controllably release the odorants as demanded. In this study, photo-driven mesoporous silica nanospheres loaded with sandela 803 was designed, prepared and named as S803@MS-S. S803@MS-S possessed ordered mesoporous, large specific surface area and pore volume. After adsorption of sandela 803, the S803@MSS was added into wallpaper to prepare fragrant wallpaper S803@MS-S-W. And this wallpaper exhibited excellent sustained and controlled release performances stimulated by light.展开更多
目的研制一种新型的具有分子靶向显像潜能的高掺钆量的介孔二氧化硅纳米粒子用于MRI。方法采用反向微乳液法将钆喷酸掺杂到介孔二氧化硅(MSNs)孔道中,制备钆喷酸掺杂的介孔二氧化硅纳米粒子(GdMSNs)。ICP-AES检测纳米粒的含钆量;透射电...目的研制一种新型的具有分子靶向显像潜能的高掺钆量的介孔二氧化硅纳米粒子用于MRI。方法采用反向微乳液法将钆喷酸掺杂到介孔二氧化硅(MSNs)孔道中,制备钆喷酸掺杂的介孔二氧化硅纳米粒子(GdMSNs)。ICP-AES检测纳米粒的含钆量;透射电镜观察纳米粒的形貌特征;3.0 T MRI系统体外观察纳米粒。结果成功制备出Gd-MSNs,电感耦合等离子体发射光谱仪测得掺钆量百分比达12.11%;制备的Gd-MSNs形态呈圆球形,直径约50~70 nm。MRI显示Gd-MSNs能显著缩短T_1和T_2的弛豫时间,表现为短T_1、短T_2的信号特点。结论成功制备的单分散、易修饰、高载药量的新型掺钆纳米材料,有望成为一种新型的多功能靶向MRI纳米对比剂。展开更多
The toxic effects to microorganism induced by nanomaterials have received considerable attentions in the past decades [1]. Herein, two diverse nanomaterials i.e. multi-walled carbon nanotubes (MWCNTs) and mesoporous s...The toxic effects to microorganism induced by nanomaterials have received considerable attentions in the past decades [1]. Herein, two diverse nanomaterials i.e. multi-walled carbon nanotubes (MWCNTs) and mesoporous silica nanospheres (MSNs) were prepared to investigate their deleterious effects on Caenorhabditis. elegans (C. elegans)[2-3]. As shown in Figure 1A, histidine functionalized MWCNTs (his-MWCNTs) were in length of ~500 nm with outer diameter ~20 nm, while fluorescein isothiocyanate dyed MSNs (FITC-MSNs) were in an average diameter of ~70 nm (Figure 1B). Microscopic images display his-MWCNTs having been ingested into intestine of C. elegans after co-incubation for 2 h, as arrowed in Figure 1C and 1E. In contrast, no MSNs were observed to be ingested after co-incubating in the same liquid medium. However, fluorescence microscopic images (Figure 1D and 1F) demonstrate that FITC-MSNs could be ingested by C. elegans after co-incubation for 24 h or longer time via seeding Kingagar plates with FITC-MSNs.展开更多
基金supported by the Natural Science Foundation of Fujian Province(Nos.2017J01822 and 2018J01347)Fujian Medical University(No.2017XQ1202)Fuzhou General Hospital(No.2017Q06)
文摘To investigate the influence of mesopores towards the solidification of self-microemulsifying drug delivery system(SMEDDS), mesoporous silica nanospheres(MSNs) and Santa Barbara Amorphous-15(SBA-15) were compared. The MSNs had hydrodynamic size of 195.35 ± 5.82 nm, and pore diameter of 2.70 nm. The SBA-15 had hydrodynamic size of 2312.19 ± 106.93 nm, and pore diameter of 10.91 nm. The MSNs and SBA-15 showed similar loading efficiency of SMEDDS containing sirolimus(SRL). However,MSNs had higher drug dissolution and in vivo absorption, with relative bioavailability of 174.62%. Thus,the length of mesopores played a more important role in solidification of SMEDDS as compared with the pore diameter. This study suggests that the SMEDDS-MSNs can be a potential candidate for oral administration of hydrophobic drugs.
基金financially supported by the National High Technology Research and Development Program (No. 2016YFA0200303)the Beijing Natural Science Foundation (No. L172046)+2 种基金the National Natural Science Foundation of China(Nos. 31522023, 51373177 and 51573188)the Beijing Municipal Science & Technology Commission (No. Z161100002616015)the "Strategic Priority Research Program Research Program" of the Chinese Academy of Sciences(No. XDA09030301-3)
文摘Fragrances are widely used in our daily life and have made great contributions to creating a clean and fresh healthy air environment. However, the rapid volatilization severely influences their storage,application and quality. Therefore, it is necessary and urgent to develop approaches to controllably release the odorants as demanded. In this study, photo-driven mesoporous silica nanospheres loaded with sandela 803 was designed, prepared and named as S803@MS-S. S803@MS-S possessed ordered mesoporous, large specific surface area and pore volume. After adsorption of sandela 803, the S803@MSS was added into wallpaper to prepare fragrant wallpaper S803@MS-S-W. And this wallpaper exhibited excellent sustained and controlled release performances stimulated by light.
文摘目的研制一种新型的具有分子靶向显像潜能的高掺钆量的介孔二氧化硅纳米粒子用于MRI。方法采用反向微乳液法将钆喷酸掺杂到介孔二氧化硅(MSNs)孔道中,制备钆喷酸掺杂的介孔二氧化硅纳米粒子(GdMSNs)。ICP-AES检测纳米粒的含钆量;透射电镜观察纳米粒的形貌特征;3.0 T MRI系统体外观察纳米粒。结果成功制备出Gd-MSNs,电感耦合等离子体发射光谱仪测得掺钆量百分比达12.11%;制备的Gd-MSNs形态呈圆球形,直径约50~70 nm。MRI显示Gd-MSNs能显著缩短T_1和T_2的弛豫时间,表现为短T_1、短T_2的信号特点。结论成功制备的单分散、易修饰、高载药量的新型掺钆纳米材料,有望成为一种新型的多功能靶向MRI纳米对比剂。
文摘The toxic effects to microorganism induced by nanomaterials have received considerable attentions in the past decades [1]. Herein, two diverse nanomaterials i.e. multi-walled carbon nanotubes (MWCNTs) and mesoporous silica nanospheres (MSNs) were prepared to investigate their deleterious effects on Caenorhabditis. elegans (C. elegans)[2-3]. As shown in Figure 1A, histidine functionalized MWCNTs (his-MWCNTs) were in length of ~500 nm with outer diameter ~20 nm, while fluorescein isothiocyanate dyed MSNs (FITC-MSNs) were in an average diameter of ~70 nm (Figure 1B). Microscopic images display his-MWCNTs having been ingested into intestine of C. elegans after co-incubation for 2 h, as arrowed in Figure 1C and 1E. In contrast, no MSNs were observed to be ingested after co-incubating in the same liquid medium. However, fluorescence microscopic images (Figure 1D and 1F) demonstrate that FITC-MSNs could be ingested by C. elegans after co-incubation for 24 h or longer time via seeding Kingagar plates with FITC-MSNs.
