Laugier-Hunziker syndrome (LHS) is an acquired pigmentary condition affecting lips, oral mucosa and acral area, frequently associated with longitudinal melanonychia. There is neither malignant predisposition nor und...Laugier-Hunziker syndrome (LHS) is an acquired pigmentary condition affecting lips, oral mucosa and acral area, frequently associated with longitudinal melanonychia. There is neither malignant predisposition nor underlying systemic abnormality associated with LHS. Herein, we present three uncommon cases of LHS with possibly new feature of nail pigmentation, which were diagnosed during the past 2 years. We also review the clinical and histological findings, differential diagnosis, and treatment of the syndrome in published literature.展开更多
This study examined whether melanonychia was more prevalent in 1) HIV positive individuals compared to HIV negative persons, 2) HIV positives exposed to zidovudine and/or stavudine and 3) those with darker skin pigmen...This study examined whether melanonychia was more prevalent in 1) HIV positive individuals compared to HIV negative persons, 2) HIV positives exposed to zidovudine and/or stavudine and 3) those with darker skin pigmentation. Procedures. 267 HIV positive and 273 HIV negative patients were examined for presence or absence of melanonychia and level of skin pigmentation using the Fitzgerald scale. Pharmacy records were examined for determining exposure to zidovudine or stavudine. Chi square, odds ratios and logistic regression were used to examine the study questions Main Findings. Melanonychia appeared in 49.1% of 267 HIV positive and 21.8% of 273 HIV negative subjects. Adjusting for skin pigmentation, HIV positives were 4.1 times more likely to have melanonychia than HIV negatives. Melanonychia was present in 54% of those receiving zidovudine and in 42% of those receiving stavudine (OR = 2.73, p = 0.05). In a multivariate model in HIV positives which included skin type, prescription of zidovudine and/or Stavudine, only dark skin (OR = 14.62, p < 0.001) and zidovudine (OR = 2.65, p < 0.03) were significant. Principal Conclusions. HIV infected persons are prone to melanonychia. This is more frequent in darker skinned persons and is enhanced in those exposed to zidovudine.展开更多
Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome(L...Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome(LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. The important differential diagnoses of mucocutaneous and nail pigmentation are provided. An accurate diagnosis is crucial to design a reasonable medical strategy, including management options, malignant transformation surveillance, and psychological support. It is important that clinicians conduct long-term follow-up and surveillance due to the potential risks of malignant transformation and local severe complications in some conditions.展开更多
Longitudinal melanonychia is not a rare clinical condition.It is mostly characterized by the presence of longitudinal,demarcated,and pigmented bands on the nail unit.The etiology is generally classified as melanocytic...Longitudinal melanonychia is not a rare clinical condition.It is mostly characterized by the presence of longitudinal,demarcated,and pigmented bands on the nail unit.The etiology is generally classified as melanocytic activation or melanocytic hyperplasia.Benign nail matrix nevi and malignant subungual melanoma are classified under the etiology of melanocytic hyperplasia.The manifestations of benign and malignant melanonychia present with similar clinical features,but the prognoses of these two conditions are quite different.Therefore,it is important to distinguish malignant melanoma from benign melanonychia.History,physical examination,dermoscopy,and biopsy are obtained or performed to help determine the diagnosis.Surgical excision is commonly performed in patients who are above 50 years of age,if the increase in width of the pigmented band is rapid or sudden,if the width of the band is over 5 mm,or if the border of the band becomes blurred.All excised specimens are subjected to pathological examination for final diagnosis.展开更多
基金supported by the National Natural Scientific Foundation of China (No. 81070839)Jiangsu Province’s Outstanding Medical Academic Leader program (No. LJ201110)
文摘Laugier-Hunziker syndrome (LHS) is an acquired pigmentary condition affecting lips, oral mucosa and acral area, frequently associated with longitudinal melanonychia. There is neither malignant predisposition nor underlying systemic abnormality associated with LHS. Herein, we present three uncommon cases of LHS with possibly new feature of nail pigmentation, which were diagnosed during the past 2 years. We also review the clinical and histological findings, differential diagnosis, and treatment of the syndrome in published literature.
文摘This study examined whether melanonychia was more prevalent in 1) HIV positive individuals compared to HIV negative persons, 2) HIV positives exposed to zidovudine and/or stavudine and 3) those with darker skin pigmentation. Procedures. 267 HIV positive and 273 HIV negative patients were examined for presence or absence of melanonychia and level of skin pigmentation using the Fitzgerald scale. Pharmacy records were examined for determining exposure to zidovudine or stavudine. Chi square, odds ratios and logistic regression were used to examine the study questions Main Findings. Melanonychia appeared in 49.1% of 267 HIV positive and 21.8% of 273 HIV negative subjects. Adjusting for skin pigmentation, HIV positives were 4.1 times more likely to have melanonychia than HIV negatives. Melanonychia was present in 54% of those receiving zidovudine and in 42% of those receiving stavudine (OR = 2.73, p = 0.05). In a multivariate model in HIV positives which included skin type, prescription of zidovudine and/or Stavudine, only dark skin (OR = 14.62, p < 0.001) and zidovudine (OR = 2.65, p < 0.03) were significant. Principal Conclusions. HIV infected persons are prone to melanonychia. This is more frequent in darker skinned persons and is enhanced in those exposed to zidovudine.
基金Supported by The National Natural Scientific Foundation of China,No.81570978the Nonprofit Industry Research Specific Fund of National Health and Family Planning Commission of China,No.201502018+1 种基金the Key Project of Science and Technology Department of Jiangsu Province,No.BL2014018the Project of Invigorating Health Care through Science,Technology and Education:the Project of Jiangsu Provincial Medical Youth Talent,No.QNRC2016118
文摘Labial and oral melanotic macules are commonly encountered in a broad range of conditions ranging from physiologic pigmentation to a sign of an underlying life-threatening disease. Although Laugier-Hunziker syndrome(LHS) shares some features of labial and oral pigmentation with a variety of conditions, it is a benign and acquired condition, frequently associated with longitudinal melanonychia. Herein, the demographic, clinical, dermoscopic, and pathological aspects of LHS were reviewed comprehensively. The important differential diagnoses of mucocutaneous and nail pigmentation are provided. An accurate diagnosis is crucial to design a reasonable medical strategy, including management options, malignant transformation surveillance, and psychological support. It is important that clinicians conduct long-term follow-up and surveillance due to the potential risks of malignant transformation and local severe complications in some conditions.
文摘Longitudinal melanonychia is not a rare clinical condition.It is mostly characterized by the presence of longitudinal,demarcated,and pigmented bands on the nail unit.The etiology is generally classified as melanocytic activation or melanocytic hyperplasia.Benign nail matrix nevi and malignant subungual melanoma are classified under the etiology of melanocytic hyperplasia.The manifestations of benign and malignant melanonychia present with similar clinical features,but the prognoses of these two conditions are quite different.Therefore,it is important to distinguish malignant melanoma from benign melanonychia.History,physical examination,dermoscopy,and biopsy are obtained or performed to help determine the diagnosis.Surgical excision is commonly performed in patients who are above 50 years of age,if the increase in width of the pigmented band is rapid or sudden,if the width of the band is over 5 mm,or if the border of the band becomes blurred.All excised specimens are subjected to pathological examination for final diagnosis.