Numerical Finite-element method (FEM) based algorithms have been widely applied for the reconstruction of the photoacoustic image. As compared with the traditional analytic methods, the FEM based methods can be easily...Numerical Finite-element method (FEM) based algorithms have been widely applied for the reconstruction of the photoacoustic image. As compared with the traditional analytic methods, the FEM based methods can be easily used to deal with problems with irregularly shaped imaging domain. However, the FEM based algorithms are usually computationally intensive because repeated manipulations of matrices with larger size are needed during the reconstruction process. To tackle such a problem, a novel method is proposed for reducing the size of the matrix to be inversed during the reconstruction process and hence speed up the inverse reconstruction without any sacrifice of the reconstruction accuracy.展开更多
In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generat...In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.展开更多
Arterial plaque from a myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit is visualized and characterized using a signal to noise ratio enhanced swept-source optical coherence tomography sys...Arterial plaque from a myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit is visualized and characterized using a signal to noise ratio enhanced swept-source optical coherence tomography system with a quadrature interferometer (QSS-OCT). A semiconductor optical amplifier is used in the sample arm to amplify the weak signal scattered from arterial plague. Signal to noise ratio improvement are demonstrated in our QSS-OCT system. This finding results into an increase of the penetration depth possible in OCT images, from 1 mm to 2 mm. Preliminary results show that vulnerable plaque with fibrous cap, macrophage accumulations and calcification in the arterial tissue are measurable with our QSS-OCT system.展开更多
文摘Numerical Finite-element method (FEM) based algorithms have been widely applied for the reconstruction of the photoacoustic image. As compared with the traditional analytic methods, the FEM based methods can be easily used to deal with problems with irregularly shaped imaging domain. However, the FEM based algorithms are usually computationally intensive because repeated manipulations of matrices with larger size are needed during the reconstruction process. To tackle such a problem, a novel method is proposed for reducing the size of the matrix to be inversed during the reconstruction process and hence speed up the inverse reconstruction without any sacrifice of the reconstruction accuracy.
文摘In this paper, a novel reconstruction method is presented for Near Infrared (NIR) 2-D imaging to recover optical absorption coefficients from laboratory phantom data. The main body of this work validates a new generation of highly efficient reconstruction algorithms called “Globally Convergent Method” (GCM) based upon actual measurements taken from brain-shape phantoms. It has been demonstrated in earlier studies using computer-simulated data that this type of reconstructions is stable for imaging complex distributions of optical absorption. The results in this paper demonstrate the excellent capability of GCM in working with experimental data measured from optical phantoms mimicking a rat brain with stroke.
文摘Arterial plaque from a myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHLMI) rabbit is visualized and characterized using a signal to noise ratio enhanced swept-source optical coherence tomography system with a quadrature interferometer (QSS-OCT). A semiconductor optical amplifier is used in the sample arm to amplify the weak signal scattered from arterial plague. Signal to noise ratio improvement are demonstrated in our QSS-OCT system. This finding results into an increase of the penetration depth possible in OCT images, from 1 mm to 2 mm. Preliminary results show that vulnerable plaque with fibrous cap, macrophage accumulations and calcification in the arterial tissue are measurable with our QSS-OCT system.
