Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-on...Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock,with mortality rates as high as 50%–70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Here, we provide the first expert consensus, the Chinese Society of Cardiology Expert Consensus Statement on the Diagnosis and Treatment of Fulminant Myocarditis, based on data from our recent clinical trial(NCT03268642). In this statement, we describe the clinical features and diagnostic criteria of fulminant myocarditis, and importantly, for the first time,we describe a new treatment regimen termed life support-based comprehensive treatment regimen. The core content of this treatment regimen includes(i) mechanical life support(applications of mechanical respirators and circulatory support systems,including intraaortic balloon pump and extracorporeal membrane oxygenation),(ii) immunological modulation by using sufficient doses of glucocorticoid, immunoglobulin and(iii) antiviral reagents using neuraminidase inhibitor. The proper application of this treatment regimen may and has helped to save the lives of many patients with fulminant myocarditis.展开更多
A simple experimental method was introduced to study the mechanical properties of reinforced concrete under shock loading. The one-stage light gas gun was used to test the me- chanical properties of reinforced concret...A simple experimental method was introduced to study the mechanical properties of reinforced concrete under shock loading. The one-stage light gas gun was used to test the me- chanical properties of reinforced concrete with different reinforcement ratios under various impact velocities. Three Mn-Cu piezoresistive pressure gauges embedded in the target were used to record the voltage-time signals, from which the stress-strain curves of reinforced concrete were obtained using Lagrangian analysis. Experimental results indicated that the load-bearing capacities of re- inforced concrete increased greatly with the impact velocity and the reinforcement ratio. The peak stress of the shock wave decreased exponentially with the propagation distance.展开更多
基金funded by the National Key Basic Research Project (2012CB518004)Natural Science Fund Key Project (81630010)
文摘Fulminant myocarditis is primarily caused by infection with any number of a variety of viruses. It arises quickly, progresses rapidly, and may lead to severe heart failure or circulatory failure presenting as rapid-onset hypotension and cardiogenic shock,with mortality rates as high as 50%–70%. Most importantly, there are no treatment options, guidelines or an expert consensus statement. Here, we provide the first expert consensus, the Chinese Society of Cardiology Expert Consensus Statement on the Diagnosis and Treatment of Fulminant Myocarditis, based on data from our recent clinical trial(NCT03268642). In this statement, we describe the clinical features and diagnostic criteria of fulminant myocarditis, and importantly, for the first time,we describe a new treatment regimen termed life support-based comprehensive treatment regimen. The core content of this treatment regimen includes(i) mechanical life support(applications of mechanical respirators and circulatory support systems,including intraaortic balloon pump and extracorporeal membrane oxygenation),(ii) immunological modulation by using sufficient doses of glucocorticoid, immunoglobulin and(iii) antiviral reagents using neuraminidase inhibitor. The proper application of this treatment regimen may and has helped to save the lives of many patients with fulminant myocarditis.
基金Project supported by the National Natural Science Foundation of China(Nos.51368048 and 11162015)
文摘A simple experimental method was introduced to study the mechanical properties of reinforced concrete under shock loading. The one-stage light gas gun was used to test the me- chanical properties of reinforced concrete with different reinforcement ratios under various impact velocities. Three Mn-Cu piezoresistive pressure gauges embedded in the target were used to record the voltage-time signals, from which the stress-strain curves of reinforced concrete were obtained using Lagrangian analysis. Experimental results indicated that the load-bearing capacities of re- inforced concrete increased greatly with the impact velocity and the reinforcement ratio. The peak stress of the shock wave decreased exponentially with the propagation distance.
