Irritable bowel syndrome (IBS) is a functional intestinal disease characterized by abdominal pain or discomfort and altered bowel habits. It has drawn great attention because of its high prevalence, reoccurring sympto...Irritable bowel syndrome (IBS) is a functional intestinal disease characterized by abdominal pain or discomfort and altered bowel habits. It has drawn great attention because of its high prevalence, reoccurring symptoms, and severe influence on patients’ lives. Many clinical studies have demonstrated the efficacy of acupuncture-moxibustion in treating IBS. Increasing attention has been paid to research regarding the action mechanisms of acupuncture-moxibustion for IBS, and the adoption of modern techniques has achieved some progress. This article reviews the latest advances among action mechanism studies from the perspectives of gastrointestinal motility, visceral hypersensitivity, the brain-gut axis, the neuroendocrine system, and the immune system. It is shown that acupuncture-moxibustion can effectively regulate the above items, and thus, this treatment should have a high efficacy in the treatment of IBS. This article also identifies existing problems in current mechanism research and raises several ideas for future studies. Further revelations regarding these action mechanisms will promote the application of acupuncture-moxibustion in treating IBS.展开更多
本文将电子束辐照技术和功能材料制备技术相结合,采用10 Me V电子束辐照法引发糊化的木薯淀粉与部分中和的丙烯酸单体进行接枝共聚反应,并采用N,N’-亚甲基双丙烯酰胺为交联剂,制备出一种淀粉接枝聚丙烯酸钠系高吸水树脂,并通过红外光谱...本文将电子束辐照技术和功能材料制备技术相结合,采用10 Me V电子束辐照法引发糊化的木薯淀粉与部分中和的丙烯酸单体进行接枝共聚反应,并采用N,N’-亚甲基双丙烯酰胺为交联剂,制备出一种淀粉接枝聚丙烯酸钠系高吸水树脂,并通过红外光谱(FTIR)和扫描电子显微镜(SEM)技术对木薯淀粉和共聚产物的官能团结构和表面形态进行验证。采用正交试验设计方法分析单体/淀粉比、辐照剂量、交联剂/单体比以及单体中和度对该反应接枝参数以及吸水性能的影响,4种因素的变化均可引起共聚产物的吸水能力变化,影响显著性次序为:单体中和度>单体/淀粉比>交联剂/单体比>辐照剂量。获得最佳吸水性能的反应条件为:AA/St=3.5 g·g-1,MBA/AA=5 mmol·mol-1,辐照剂量D=6k Gy,中和度为70%,上述条件下获得共聚产物的吸水倍数为435 g·g-1。本文为采用电子束法制备高吸水材料提供了科学依据与技术支持。展开更多
Blast, caused by Magnaporthe oryzae, is one of the most widespread and destructive diseases of rice. Breeding durable resistant cultivars （cvs） can be achieved by pyramiding of various resistance （R） genes. Pia, c...Blast, caused by Magnaporthe oryzae, is one of the most widespread and destructive diseases of rice. Breeding durable resistant cultivars （cvs） can be achieved by pyramiding of various resistance （R） genes. Pia, carded by cv. Aichi Asahi, was evaluated against 612 isolates of M. oryzae collected from 10 Chinese provinces. The Pia gene expresses weak resistance in all the provinces except for Jiangsu. Genomic position-ready marker-based linkage analysis was carded out in a mapping population consisting of 800 F2 plants derived from a cross of Aichi Asahi×Kasalath. The locus was defined in an interval of approximately 90 kb, flanked by markers A16 and A21. Four candidate genes （Pia-1, Pia-2, Pia-3, and Pia-4）, all having the R gene conserved structure, were predicted in the interval using the cv. Nipponbare genomic sequence. Four candidate resistance gene （CRG） markers （A17, A25, A26, and A27）, derived from the four candidates, were subjected to genotyping with the recombinants detected at the flanking markers. The first three markers completely co-segregated with the Pia locus, and the fourth was absent in the Aichi Asahi genome and disordered with the Pia locus and its flanking markers, indicating that the fourth candidate gene, Pia-4, could be excluded. Co-segregation marker-based genotyping of the three sets of differentials with known R gene genotypes revealed that the genotype of A26 （Pia-3） perfectly matched the R gene genotype of Pia, indicating that Pia-3 is the strongest candidate gene for Pia.展开更多
基金Supported by National Natural Science Foundation of China,No.81273843,No.81072879National Key Basic Research Program of China,No.2009CB522900
文摘Irritable bowel syndrome (IBS) is a functional intestinal disease characterized by abdominal pain or discomfort and altered bowel habits. It has drawn great attention because of its high prevalence, reoccurring symptoms, and severe influence on patients’ lives. Many clinical studies have demonstrated the efficacy of acupuncture-moxibustion in treating IBS. Increasing attention has been paid to research regarding the action mechanisms of acupuncture-moxibustion for IBS, and the adoption of modern techniques has achieved some progress. This article reviews the latest advances among action mechanism studies from the perspectives of gastrointestinal motility, visceral hypersensitivity, the brain-gut axis, the neuroendocrine system, and the immune system. It is shown that acupuncture-moxibustion can effectively regulate the above items, and thus, this treatment should have a high efficacy in the treatment of IBS. This article also identifies existing problems in current mechanism research and raises several ideas for future studies. Further revelations regarding these action mechanisms will promote the application of acupuncture-moxibustion in treating IBS.
基金supported by the National Transgenic Research Projects (Grant No.2009ZX08009-023B)the National Basic Research Program of China(Grant No.2011CB1007)the National Commonweal Specialized Research Project(Grant No.200803008)
文摘Blast, caused by Magnaporthe oryzae, is one of the most widespread and destructive diseases of rice. Breeding durable resistant cultivars （cvs） can be achieved by pyramiding of various resistance （R） genes. Pia, carded by cv. Aichi Asahi, was evaluated against 612 isolates of M. oryzae collected from 10 Chinese provinces. The Pia gene expresses weak resistance in all the provinces except for Jiangsu. Genomic position-ready marker-based linkage analysis was carded out in a mapping population consisting of 800 F2 plants derived from a cross of Aichi Asahi×Kasalath. The locus was defined in an interval of approximately 90 kb, flanked by markers A16 and A21. Four candidate genes （Pia-1, Pia-2, Pia-3, and Pia-4）, all having the R gene conserved structure, were predicted in the interval using the cv. Nipponbare genomic sequence. Four candidate resistance gene （CRG） markers （A17, A25, A26, and A27）, derived from the four candidates, were subjected to genotyping with the recombinants detected at the flanking markers. The first three markers completely co-segregated with the Pia locus, and the fourth was absent in the Aichi Asahi genome and disordered with the Pia locus and its flanking markers, indicating that the fourth candidate gene, Pia-4, could be excluded. Co-segregation marker-based genotyping of the three sets of differentials with known R gene genotypes revealed that the genotype of A26 （Pia-3） perfectly matched the R gene genotype of Pia, indicating that Pia-3 is the strongest candidate gene for Pia.
